PMID- 34995724
OWN - NLM
STAT- MEDLINE
DCOM- 20220303
LR  - 20220303
IS  - 1873-6815 (Electronic)
IS  - 0531-5565 (Linking)
VI  - 159
DP  - 2022 Mar
TI  - Brainstem auditory evoked potential in cognitive impairment in patients with type 
      2 diabetes mellitus.
PG  - 111684
LID - S0531-5565(21)00466-6 [pii]
LID - 10.1016/j.exger.2021.111684 [doi]
AB  - PURPOSE: Type 2 diabetes mellitus (T2DM) can cause mild cognitive impairment 
      (MCI) which threatens the health of patients. So the diagnosis of MCI is 
      particularly important. It is reported that brainstem auditory evoked potential 
      (BAEP) is a sensitive tool to detect the brainstem function in patients with 
      T2DM. This study aimed to investigate the relationship between BAEP and MCI in 
      patients with T2DM. METHODS: A total of 244 T2DM patients with normal hearing, 
      including 117 normal cognition patients and 127 MCI patients, were recruited in 
      this cross-sectional study. Each subject underwent the BAEP examination. The 
      diagnosis of MCI was based on the diagnostic guideline developed by the National 
      Institute on Aging-Alzheimer's Association workgroups. The Montreal Cognitive 
      Assessment (MoCA) was used to assess the cognitive function of the subjects. 
      RESULTS: Compared with the normal cognition group, the patients in the MCI group 
      had longer latencies of waves III and V and interpeak latencies (IPL) I-V in both 
      ears (P < 0.05). The significant negative correlations were found between the 
      latencies of waves III, V, IPL I-V, and MoCA score in both ears (P < 0.05). 
      Logistic regression showed that the prolongations of latunits of waves III and V 
      and IPL I-V in both ears were still associated with MCI after adjustment for 
      mixed factors (P < 0.05). CONCLUSION: These results indicate abnormal auditory 
      pathway in brainstem of T2DM patients with MCI. BAEP may contribute to the 
      clinical diagnosis of MCI in patients with T2DM.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Yu, Zi-Wei
AU  - Yu ZW
AD  - Department of Endocrinology, First Affiliated Hospital of Harbin Medical 
      University, Harbin 150001, China.
FAU - Wang, Ying
AU  - Wang Y
AD  - Department of Endocrinology, First Affiliated Hospital of Harbin Medical 
      University, Harbin 150001, China.
FAU - Li, Xin
AU  - Li X
AD  - Department of Endocrinology, First Affiliated Hospital of Harbin Medical 
      University, Harbin 150001, China.
FAU - Fu, Yu-Hong
AU  - Fu YH
AD  - Department of Endocrinology, First Affiliated Hospital of Harbin Medical 
      University, Harbin 150001, China.
FAU - Yuan, Yue
AU  - Yuan Y
AD  - Department of Endocrinology, First Affiliated Hospital of Harbin Medical 
      University, Harbin 150001, China.
FAU - Li, Hui-Yao
AU  - Li HY
AD  - Department of Endocrinology, First Affiliated Hospital of Harbin Medical 
      University, Harbin 150001, China.
FAU - Gao, Xin-Yuan
AU  - Gao XY
AD  - Department of Endocrinology, First Affiliated Hospital of Harbin Medical 
      University, Harbin 150001, China. Electronic address: m15124768260@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220104
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
SB  - IM
MH  - Cognition
MH  - *Cognitive Dysfunction/complications/etiology
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/complications/psychology
MH  - Evoked Potentials, Auditory, Brain Stem/physiology
MH  - Humans
OTO - NOTNLM
OT  - Brainstem auditory evoked potential
OT  - Brainstem lesion
OT  - Mild cognitive impairment
OT  - Type 2 diabetes mellitus
EDAT- 2022/01/08 06:00
MHDA- 2022/03/04 06:00
CRDT- 2022/01/07 20:14
PHST- 2021/01/15 00:00 [received]
PHST- 2021/12/12 00:00 [revised]
PHST- 2021/12/25 00:00 [accepted]
PHST- 2022/01/08 06:00 [pubmed]
PHST- 2022/03/04 06:00 [medline]
PHST- 2022/01/07 20:14 [entrez]
AID - S0531-5565(21)00466-6 [pii]
AID - 10.1016/j.exger.2021.111684 [doi]
PST - ppublish
SO  - Exp Gerontol. 2022 Mar;159:111684. doi: 10.1016/j.exger.2021.111684. Epub 2022 
      Jan 4.