PMID- 34995788
OWN - NLM
STAT- MEDLINE
DCOM- 20220308
LR  - 20220308
IS  - 1873-1597 (Electronic)
IS  - 1572-1000 (Linking)
VI  - 37
DP  - 2022 Mar
TI  - Benefits and safety of photodynamic therapy in patients with hilar 
      cholangiocarcinoma: A meta-analysis.
PG  - 102712
LID - S1572-1000(22)00001-1 [pii]
LID - 10.1016/j.pdpdt.2022.102712 [doi]
AB  - BACKGROUND: Photodynamic therapy (PDT) is a therapy evaluated for the treatment 
      of cancers resistant to standard oncological treatments. PDT might be beneficial 
      for the palliation of hilar cholangiocarcinoma. AIM: To evaluate the efficacy and 
      safety of PDT for treating hilar cholangiocarcinoma. METHODS: PubMed, Embase, the 
      Cochrane Library, and Web of Science were searched for articles published up to 
      May 2021. The patients were grouped as PDT+stent vs. stent alone. The outcomes 
      were survival, quality of life, and adverse events (AEs). Data were summarized 
      using hazard ratios (HRs), odds ratios (ORs), and 95% confidence intervals (CIs). 
      RESULTS: Six studies were included in this meta-analysis. There were 235 and 211 
      patients in the PDT+stent and stent groups, respectively. The 1-year survival 
      rate of the PDT+stent group was 0.56, and that of the control group was 0.25. The 
      2-year survival rate of the PDT+stent group was 0.16, and that of the control 
      group was 0.07. PDT significantly prolonged overall survival compared to the 
      controls (P = 0.002). No differences were detected in the occurrence of 
      cholangitis (P = 0.996) and all other AEs (early complications, stent 
      malfunction, total AEs, acute pancreatitis, liver abscess, and biliary 
      hemorrhage) between the two groups. CONCLUSION: PDT in patients with hilar 
      cholangiocarcinoma could improve survival without additional AEs. Large-scale 
      randomized controlled trials are needed to confirm the findings.
CI  - Copyright (c) 2022. Published by Elsevier B.V.
FAU - Chen, Pengcheng
AU  - Chen P
AD  - Department of General Surgery, Jiading District Central Hospital Affiliated 
      Shanghai University of Medicine & Health Sciences, Shanghai, China.
FAU - Yang, Ting
AU  - Yang T
AD  - Department of General Surgery, Jiading District Central Hospital Affiliated 
      Shanghai University of Medicine & Health Sciences, Shanghai, China.
FAU - Shi, Peidong
AU  - Shi P
AD  - Department of General Surgery, Jiading District Central Hospital Affiliated 
      Shanghai University of Medicine & Health Sciences, Shanghai, China.
FAU - Shen, Jiangbo
AU  - Shen J
AD  - Department of General Surgery, Jiading District Central Hospital Affiliated 
      Shanghai University of Medicine & Health Sciences, Shanghai, China.
FAU - Feng, Qingchun
AU  - Feng Q
AD  - Department of General Surgery, Jiading District Central Hospital Affiliated 
      Shanghai University of Medicine & Health Sciences, Shanghai, China.
FAU - Su, Jingen
AU  - Su J
AD  - Department of General Surgery, Jiading District Central Hospital Affiliated 
      Shanghai University of Medicine & Health Sciences, Shanghai, China. Electronic 
      address: sjg7288@sina.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20220105
PL  - Netherlands
TA  - Photodiagnosis Photodyn Ther
JT  - Photodiagnosis and photodynamic therapy
JID - 101226123
SB  - IM
MH  - Acute Disease
MH  - *Bile Duct Neoplasms/drug therapy
MH  - Bile Ducts, Intrahepatic/pathology
MH  - *Cholangiocarcinoma/drug therapy
MH  - Humans
MH  - *Klatskin Tumor/drug therapy/etiology/pathology
MH  - *Pancreatitis/etiology/pathology
MH  - *Photochemotherapy/methods
MH  - Quality of Life
MH  - Stents
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Biliary stent
OT  - Hepatobiliary cancer
OT  - Hilar cholangiocarcinoma
OT  - Meta-analysis
OT  - Palliative treatment
OT  - Photodynamic therapy
EDAT- 2022/01/08 06:00
MHDA- 2022/03/09 06:00
CRDT- 2022/01/07 20:15
PHST- 2021/10/25 00:00 [received]
PHST- 2021/12/16 00:00 [revised]
PHST- 2022/01/03 00:00 [accepted]
PHST- 2022/01/08 06:00 [pubmed]
PHST- 2022/03/09 06:00 [medline]
PHST- 2022/01/07 20:15 [entrez]
AID - S1572-1000(22)00001-1 [pii]
AID - 10.1016/j.pdpdt.2022.102712 [doi]
PST - ppublish
SO  - Photodiagnosis Photodyn Ther. 2022 Mar;37:102712. doi: 
      10.1016/j.pdpdt.2022.102712. Epub 2022 Jan 5.