PMID- 34996522 OWN - NLM STAT- MEDLINE DCOM- 20220309 LR - 20220531 IS - 1758-9193 (Electronic) VI - 14 IP - 1 DP - 2022 Jan 7 TI - Plasma MCP-1 and changes on cognitive function in community-dwelling older adults. PG - 5 LID - 10.1186/s13195-021-00940-2 [doi] LID - 5 AB - BACKGROUND: Monocyte Chemoattractant Protein-1 (MCP-1), a glial-derived chemokine, mediates neuroinflammation and may regulate memory outcomes among older adults. We aimed to explore the associations of plasma MCP-1 levels (alone and in combination with beta-amyloid deposition-Abeta(42/40)) with overall and domain-specific cognitive evolution among older adults. METHODS: Secondary analyses including 1097 subjects (mean age = 75.3 years +/- 4.4; 63.8% women) from the Multidomain Alzheimer Preventive Trial (MAPT). MCP-1 (higher is worse) and Abeta(42/40) (lower is worse) were measured in plasma collected at year 1. MCP-1 in continuous and as a dichotomy (values in the highest quartile (MCP-1(+))) were used, as well as a dichotomy of Abeta(42/40). Outcomes were measured annually over 4 years and included the following: cognitive composite z-score (CCS), the Mini-Mental State Examination (MMSE), and Clinical Dementia Rating (CDR) sum of boxes (overall cognitive function); composite executive function z-score, composite attention z-score, Free and Cued Selective Reminding Test (FCSRT - memory). RESULTS: Plasma MCP-1 as a continuous variable was associated with the worsening of episodic memory over 4 years of follow-up, specifically in measures of free and cued delayed recall. MCP-1(+) was associated with worse evolution in the CCS (4-year between-group difference: beta = -0.14, 95%CI = -0.26, -0.02) and the CDR sum of boxes (2-year: beta = 0.19, 95%CI = 0.06, 0.32). In domain-specific analyses, MCP-1(+) was associated with declines in the FCSRT delayed recall sub-domains. In the presence of low Abeta(42/40), MCP-1(+) was not associated with greater declines in cognitive functions. The interaction with continuous biomarker values Abeta(42/40)x MCP-1 x time was significant in models with CDR sum of boxes and FCSRT DTR as dependent variables. CONCLUSIONS: Baseline plasma MCP-1 levels were associated with longitudinal declines in overall cognitive and episodic memory performance in older adults over a 4-year follow-up. How plasma MCP-1 interacts with Abeta(42/40) to determine cognitive decline at different stages of cognitive decline/dementia should be clarified by further research. The MCP-1 association on cognitive decline was strongest in those with amyloid plaques, as measured by blood plasma Abeta(42/40.) CI - (c) 2022. The Author(s). FAU - Sanchez-Sanchez, Juan Luis AU - Sanchez-Sanchez JL AD - Gerontopole de Toulouse, Institut du Vieillissement, Centre Hospitalier-Universitaire de Toulouse, 37 allees Jules Guesde, 31000, Toulouse, France. AD - Faculty of Sport Sciences, Universidad Europea de Madrid, Villaviciosa de Odon, 28670, Madrid, Spain. FAU - Giudici, Kelly V AU - Giudici KV AD - Gerontopole de Toulouse, Institut du Vieillissement, Centre Hospitalier-Universitaire de Toulouse, 37 allees Jules Guesde, 31000, Toulouse, France. FAU - Guyonnet, Sophie AU - Guyonnet S AD - Gerontopole de Toulouse, Institut du Vieillissement, Centre Hospitalier-Universitaire de Toulouse, 37 allees Jules Guesde, 31000, Toulouse, France. AD - CERPOP, Inserm 1295, Universite de Toulouse, UPS, Toulouse, France. FAU - Delrieu, Julien AU - Delrieu J AD - Gerontopole de Toulouse, Institut du Vieillissement, Centre Hospitalier-Universitaire de Toulouse, 37 allees Jules Guesde, 31000, Toulouse, France. AD - CERPOP, Inserm 1295, Universite de Toulouse, UPS, Toulouse, France. FAU - Li, Yan AU - Li Y AD - Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA. AD - Division of Biostatistics, Washington University in St. Louis, St. Louis, MO, USA. FAU - Bateman, Randall J AU - Bateman RJ AD - Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA. AD - Division of Biostatistics, Washington University in St. Louis, St. Louis, MO, USA. AD - Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, MO, USA. AD - Hope Center for Neurological Disorders, Washington University in St. Louis, St. Louis, MO, USA. FAU - Parini, Angelo AU - Parini A AD - Institut des Maladies Metaboliques et Cardiovasculaires, Inserm/Universite Paul Sabatier UMR 1048 - I2MC 1, Toulouse, France. FAU - Vellas, Bruno AU - Vellas B AD - Gerontopole de Toulouse, Institut du Vieillissement, Centre Hospitalier-Universitaire de Toulouse, 37 allees Jules Guesde, 31000, Toulouse, France. AD - CERPOP, Inserm 1295, Universite de Toulouse, UPS, Toulouse, France. FAU - de Souto Barreto, Philipe AU - de Souto Barreto P AD - Gerontopole de Toulouse, Institut du Vieillissement, Centre Hospitalier-Universitaire de Toulouse, 37 allees Jules Guesde, 31000, Toulouse, France. philipebarreto81@yahoo.com.br. AD - CERPOP, Inserm 1295, Universite de Toulouse, UPS, Toulouse, France. philipebarreto81@yahoo.com.br. CN - MAPT/DSA Group LA - eng PT - Clinical Trial PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220107 PL - England TA - Alzheimers Res Ther JT - Alzheimer's research & therapy JID - 101511643 RN - 0 (Amyloid beta-Peptides) RN - 0 (Chemokine CCL2) SB - IM MH - Aged MH - *Alzheimer Disease/psychology MH - Amyloid beta-Peptides MH - Chemokine CCL2 MH - Cognition/physiology MH - *Cognitive Dysfunction/diagnosis MH - Female MH - Humans MH - Independent Living MH - Male MH - Neuropsychological Tests MH - Plasma PMC - PMC8742409 OTO - NOTNLM OT - Alzheimer's disease OT - Cognitive function OT - Episodic memory OT - MCP-1 OT - Older adults COIS- The authors declare that they have no competing interests. FIR - Vellas, Bruno IR - Vellas B FIR - Guyonnet, Sophie IR - Guyonnet S FIR - Carrie, Isabelle IR - Carrie I FIR - Brigitte, Laureane IR - Brigitte L FIR - Faisant, Catherine IR - Faisant C FIR - Lala, Francoise IR - Lala F FIR - Delrieu, Julien IR - Delrieu J FIR - Villars, Helene IR - Villars H FIR - Combrouze, Emeline IR - Combrouze E FIR - Badufle, Carole IR - Badufle C FIR - Zueras, Audrey IR - Zueras A FIR - Andrieu, Sandrine IR - Andrieu S FIR - Cantet, Christelle IR - Cantet C FIR - Morin, Christophe IR - Morin C FIR - Van Kan, Gabor Abellan IR - Van Kan GA FIR - Dupuy, Charlotte IR - Dupuy C FIR - Rolland, Yves IR - Rolland Y FIR - Caillaud, Celine IR - Caillaud C FIR - Ousset, Pierre-Jean IR - Ousset PJ FIR - Lala, Francoise IR - Lala F FIR - Willis, Sherry IR - Willis S FIR - Belleville, Sylvie IR - Belleville S FIR - Gilbert, Brigitte IR - Gilbert B FIR - Fontaine, Francine IR - Fontaine F FIR - Dartigues, Jean-Francois IR - Dartigues JF FIR - Marcet, Isabelle IR - Marcet I FIR - Delva, Fleur IR - Delva F FIR - Foubert, Alexandra IR - Foubert A FIR - Cerda, Sandrine IR - Cerda S FIR - Marie-Noelle-Cuffi IR - Marie-Noelle-Cuffi FIR - Costes, Corinne IR - Costes C FIR - Rouaud, Olivier IR - Rouaud O FIR - Manckoundia, Patrick IR - Manckoundia P FIR - Quipourt, Valerie IR - Quipourt V FIR - Marilier, Sophie IR - Marilier S FIR - Franon, Evelyne IR - Franon E FIR - Bories, Lawrence IR - Bories L FIR - Pader, Marie-Laure IR - Pader ML FIR - Basset, Marie-France IR - Basset MF FIR - Lapoujade, Bruno IR - Lapoujade B FIR - Faure, Valerie IR - Faure V FIR - Tong, Michael Li Yung IR - Tong MLY FIR - Malick-Loiseau, Christine IR - Malick-Loiseau C FIR - Cazaban-Campistron, Evelyne IR - Cazaban-Campistron E FIR - Desclaux, Francoise IR - Desclaux F FIR - Blatge, Colette IR - Blatge C FIR - Dantoine, Thierry IR - Dantoine T FIR - Laubarie-Mouret, Cecile IR - Laubarie-Mouret C FIR - Saulnier, Isabelle IR - Saulnier I FIR - Clement, Jean-Pierre IR - Clement JP FIR - Picat, Marie-Agnes IR - Picat MA FIR - Bernard-Bourzeix, Laurence IR - Bernard-Bourzeix L FIR - Willebois, Stephanie IR - Willebois S FIR - Desormais, Ileana IR - Desormais I FIR - Cardinaud, Noelle IR - Cardinaud N FIR - Bonnefoy, Marc IR - Bonnefoy M FIR - Livet, Pierre IR - Livet P FIR - Rebaudet, Pascale IR - Rebaudet P FIR - Gedeon, Claire IR - Gedeon C FIR - Burdet, Catherine IR - Burdet C FIR - Terracol, Flavien IR - Terracol F FIR - Pesce, Alain IR - Pesce A FIR - Roth, Stephanie IR - Roth S FIR - Chaillou, Sylvie IR - Chaillou S FIR - Louchart, Sandrine IR - Louchart S FIR - Sudres, Kristel IR - Sudres K FIR - Lebrun, Nicolas IR - Lebrun N FIR - Barro-Belaygues, Nadege IR - Barro-Belaygues N FIR - Touchon, Jacques IR - Touchon J FIR - Bennys, Karim IR - Bennys K FIR - Gabelle, Audrey IR - Gabelle A FIR - Romano, Aurelia IR - Romano A FIR - Touati, Lynda IR - Touati L FIR - Marelli, Cecilia IR - Marelli C FIR - Pays, Cecile IR - Pays C FIR - Robert, Philippe IR - Robert P FIR - Le Duff, Franck IR - Le Duff F FIR - Gervais, Claire IR - Gervais C FIR - Gonfrier, Sebastien IR - Gonfrier S FIR - Gasnier, Yannick IR - Gasnier Y FIR - Bordes, Serge IR - Bordes S FIR - Begorre, Daniele IR - Begorre D FIR - Carpuat, Christian IR - Carpuat C FIR - Khales, Khaled IR - Khales K FIR - Lefebvre, Jean-Francois IR - Lefebvre JF FIR - El Idrissi, Samira Misbah IR - El Idrissi SM FIR - Skolil, Pierre IR - Skolil P FIR - Salles, Jean-Pierre IR - Salles JP FIR - Dufouil, Carole IR - Dufouil C FIR - Lehericy, Stephane IR - Lehericy S FIR - Chupin, Marie IR - Chupin M FIR - Mangin, Jean-Francois IR - Mangin JF FIR - Bouhayia, Ali IR - Bouhayia A FIR - Allard, Michele IR - Allard M FIR - Ricolfi, Frederic IR - Ricolfi F FIR - Dubois, Dominique IR - Dubois D FIR - Martel, Marie Paule Bonceour IR - Martel MPB FIR - Cotton, Francois IR - Cotton F FIR - Bonafe, Alain IR - Bonafe A FIR - Chanalet, Stephane IR - Chanalet S FIR - Hugon, Francoise IR - Hugon F FIR - Bonneville, Fabrice IR - Bonneville F FIR - Cognard, Christophe IR - Cognard C FIR - Chollet, Francois IR - Chollet F FIR - Payoux, Pierre IR - Payoux P FIR - Voisin, Thierry IR - Voisin T FIR - Peiffer, Sophie IR - Peiffer S FIR - Hitzel, Anne IR - Hitzel A FIR - Zanca, Michel IR - Zanca M FIR - Monteil, Jacques IR - Monteil J FIR - Darcourt, Jacques IR - Darcourt J FIR - Molinier, Laurent IR - Molinier L FIR - Derumeaux, Helene IR - Derumeaux H FIR - Costa, Nadege IR - Costa N FIR - Perret, Bertrand IR - Perret B FIR - Vinel, Claire IR - Vinel C FIR - Caspar-Bauguil, Sylvie IR - Caspar-Bauguil S FIR - Olivier-Abbal, Pascale IR - Olivier-Abbal P FIR - Coley, Nicola IR - Coley N EDAT- 2022/01/09 06:00 MHDA- 2022/03/11 06:00 PMCR- 2022/01/07 CRDT- 2022/01/08 05:36 PHST- 2021/07/30 00:00 [received] PHST- 2021/11/16 00:00 [accepted] PHST- 2022/01/08 05:36 [entrez] PHST- 2022/01/09 06:00 [pubmed] PHST- 2022/03/11 06:00 [medline] PHST- 2022/01/07 00:00 [pmc-release] AID - 10.1186/s13195-021-00940-2 [pii] AID - 940 [pii] AID - 10.1186/s13195-021-00940-2 [doi] PST - epublish SO - Alzheimers Res Ther. 2022 Jan 7;14(1):5. doi: 10.1186/s13195-021-00940-2.