PMID- 34997060 OWN - NLM STAT- MEDLINE DCOM- 20220228 LR - 20220228 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 12 IP - 1 DP - 2022 Jan 7 TI - A scoring system combining clinical, radiological, and histopathological examinations for differential diagnosis between lipoma and atypical lipomatous tumor/well-differentiated liposarcoma. PG - 237 LID - 10.1038/s41598-021-04004-1 [doi] LID - 237 AB - This study evaluated the diagnostic accuracy of clinical, radiological, and histopathological examinations for differential diagnosis between atypical lipomatous tumor (ALT)/well-differentiated liposarcoma (WDLS) and lipoma, and aimed to develop a new combined scoring system for the preoperative diagnosis of ALT/WDLS. Eighty-nine lipomas and 56 ALT/WDLS were included and their clinical characteristics, magnetic resonance imaging (MRI) findings, histological findings by hematoxylin and eosin (HE) staining were investigated. Then, univariate and multivariate logistic regression analyses were performed for the findings, and a combined scoring system consisted of predictive factors of ALT/WDLS was developed. The univariate and multivariate logistic regression analyses revealed that tumor location (lower extremity), deep site, size (> 11 cm), thick septa (> 2 mm), enhancement of septa or nodular lesions, and lipoblasts were significantly different for the diagnosis of ALT/WDLS. We developed a combined scoring system based on the six predictive factors (total 0-16 points, the cutoff was 9 points). The area under the curve was 0.945, and sensitivity was 87.6% and specificity was 91.1% by the receiver operating characteristics curve. This combined scoring system does not require special equipment and reagents such as fluorescence in situ hybridization (FISH), and anyone can use it easily in many medical institutions with high diagnostic accuracy. CI - (c) 2022. The Author(s). FAU - Asano, Yohei AU - Asano Y AD - Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa city, Ishikawa, 920-8641, Japan. FAU - Miwa, Shinji AU - Miwa S AD - Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa city, Ishikawa, 920-8641, Japan. FAU - Yamamoto, Norio AU - Yamamoto N AD - Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa city, Ishikawa, 920-8641, Japan. norinori@med.kanazawa-u.ac.jp. FAU - Hayashi, Katsuhiro AU - Hayashi K AD - Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa city, Ishikawa, 920-8641, Japan. FAU - Takeuchi, Akihiko AU - Takeuchi A AD - Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa city, Ishikawa, 920-8641, Japan. FAU - Igarashi, Kentaro AU - Igarashi K AD - Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa city, Ishikawa, 920-8641, Japan. FAU - Yonezawa, Hirotaka AU - Yonezawa H AD - Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa city, Ishikawa, 920-8641, Japan. FAU - Araki, Yoshihiro AU - Araki Y AD - Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa city, Ishikawa, 920-8641, Japan. FAU - Morinaga, Sei AU - Morinaga S AD - Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa city, Ishikawa, 920-8641, Japan. FAU - Nojima, Takayuki AU - Nojima T AD - Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa city, Ishikawa, 920-8641, Japan. AD - Department of Pathology, Kanazawa University Hospital, 13-1 Takaramachi, Kanazawa city, Ishikawa, 920-8641, Japan. FAU - Ikeda, Hiroko AU - Ikeda H AD - Department of Pathology, Kanazawa University Hospital, 13-1 Takaramachi, Kanazawa city, Ishikawa, 920-8641, Japan. FAU - Tsuchiya, Hiroyuki AU - Tsuchiya H AD - Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa city, Ishikawa, 920-8641, Japan. LA - eng PT - Journal Article DEP - 20220107 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - EC 2.3.2.27 (Proto-Oncogene Proteins c-mdm2) RN - EC 2.7.11.22 (CDK4 protein, human) RN - EC 2.7.11.22 (Cyclin-Dependent Kinase 4) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - Cell Differentiation MH - Cohort Studies MH - Cyclin-Dependent Kinase 4/genetics MH - Diagnosis, Differential MH - Female MH - Humans MH - In Situ Hybridization, Fluorescence MH - Lipoma/*diagnosis/diagnostic imaging/genetics/physiopathology MH - Liposarcoma/*diagnosis/diagnostic imaging/genetics/physiopathology MH - Magnetic Resonance Imaging MH - Male MH - Middle Aged MH - Proto-Oncogene Proteins c-mdm2/genetics MH - Young Adult PMC - PMC8742117 COIS- The authors declare no competing interests. EDAT- 2022/01/09 06:00 MHDA- 2022/03/01 06:00 PMCR- 2022/01/07 CRDT- 2022/01/08 05:56 PHST- 2021/06/07 00:00 [received] PHST- 2021/12/13 00:00 [accepted] PHST- 2022/01/08 05:56 [entrez] PHST- 2022/01/09 06:00 [pubmed] PHST- 2022/03/01 06:00 [medline] PHST- 2022/01/07 00:00 [pmc-release] AID - 10.1038/s41598-021-04004-1 [pii] AID - 4004 [pii] AID - 10.1038/s41598-021-04004-1 [doi] PST - epublish SO - Sci Rep. 2022 Jan 7;12(1):237. doi: 10.1038/s41598-021-04004-1.