PMID- 34997602
OWN - NLM
STAT- MEDLINE
DCOM- 20220314
LR  - 20220314
IS  - 1540-8175 (Electronic)
IS  - 0742-2822 (Linking)
VI  - 39
IP  - 2
DP  - 2022 Feb
TI  - Three-dimensional right ventriculo-arterial coupling as an independent 
      determinant of severe heart failure symptoms in patients with dilated 
      cardiomyopathy.
PG  - 194-203
LID - 10.1111/echo.15288 [doi]
AB  - BACKGROUND: Right ventricular-pulmonary artery coupling (RVPAC) is a predictor of 
      outcome in pulmonary hypertension. However, the role of this parameter in dilated 
      cardiomyopathy (DCM) remains to be established. The aim of this study was to 
      assess the contribution of RVPAC to the occurrence of severe heart failure (HF) 
      symptoms in patients with DCM using three-dimensional (3D) echocardiography. 
      METHODS: We prospectively screened 139 outpatients with DCM, 105 of whom were 
      enrolled and underwent 3D echocardiographic assessment. RVPAC was estimated 
      non-invasively as the 3D right ventricular stroke volume (SV) to end-systolic 
      volume (ESV) ratio. Severe HF symptoms were defined by New York Heart Association 
      (NYHA) class III or IV. We evaluated differences in RVPAC across NYHA classes and 
      the ability of RVPAC to predict severe symptoms. RESULTS: Mean left ventricular 
      (LV) ejection fraction was 28+/-7%. Mean RVPAC was 0.77+/-0.30 and it was 
      significantly more impaired with increasing symptom severity (p = 0.001). RVPAC 
      was the only independent determinant of severe HF symptoms, after adjusting for 
      age, diuretic use, LV systolic function, LV diastolic function, and pulmonary 
      artery systolic pressure (OR 0.035 [95% CI, 0.004-0.312], p = 0.003). By 
      receiver-operating characteristic analysis, the RVPAC cut-off value for 
      predicting severely symptomatic status was 0.54 (area under the curve = 0.712, 
      p < 0.001). CONCLUSION: 3D echocardiographic SV/ESV ratio is an independent 
      correlate of severe HF symptoms in patients with DCM. 3D RVPAC might prove to be 
      a useful risk stratification tool for these patients, should it be further 
      validated in larger studies.
CI  - (c) 2022 Wiley Periodicals LLC.
FAU - Vijiiac, Aura
AU  - Vijiiac A
AUID- ORCID: 0000-0002-5010-3433
AD  - "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
AD  - Emergency Clinical Hospital, Bucharest, Romania.
FAU - Onciul, Sebastian
AU  - Onciul S
AD  - "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
AD  - Emergency Clinical Hospital, Bucharest, Romania.
FAU - Deaconu, Silvia
AU  - Deaconu S
AD  - "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
AD  - Emergency Clinical Hospital, Bucharest, Romania.
FAU - Vatasescu, Radu
AU  - Vatasescu R
AD  - "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
AD  - Emergency Clinical Hospital, Bucharest, Romania.
FAU - Guzu, Claudia
AU  - Guzu C
AD  - Emergency Clinical Hospital, Bucharest, Romania.
FAU - Verinceanu, Violeta
AU  - Verinceanu V
AD  - Emergency Clinical Hospital, Bucharest, Romania.
FAU - Scarlatescu, Alina
AU  - Scarlatescu A
AD  - Emergency Clinical Hospital, Bucharest, Romania.
FAU - Zamfir, Diana
AU  - Zamfir D
AD  - Emergency Clinical Hospital, Bucharest, Romania.
FAU - Petre, Ioana
AU  - Petre I
AD  - "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
AD  - Emergency Clinical Hospital, Bucharest, Romania.
FAU - Scafa-Udriste, Alexandru
AU  - Scafa-Udriste A
AD  - "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
AD  - Emergency Clinical Hospital, Bucharest, Romania.
FAU - Dorobantu, Maria
AU  - Dorobantu M
AD  - "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
AD  - Emergency Clinical Hospital, Bucharest, Romania.
LA  - eng
PT  - Journal Article
DEP - 20220107
PL  - United States
TA  - Echocardiography
JT  - Echocardiography (Mount Kisco, N.Y.)
JID - 8511187
SB  - IM
MH  - *Cardiomyopathy, Dilated/complications/diagnostic imaging
MH  - *Heart Failure/complications/diagnostic imaging
MH  - Humans
MH  - Prognosis
MH  - Stroke Volume
MH  - Ventricular Function, Left
MH  - Ventricular Function, Right
OTO - NOTNLM
OT  - SV/ESV ratio
OT  - dilated cardiomyopathy
OT  - heart failure
OT  - right ventricular-pulmonary artery coupling
OT  - three-dimensional echocardiography
EDAT- 2022/01/09 06:00
MHDA- 2022/03/15 06:00
CRDT- 2022/01/08 06:17
PHST- 2021/12/03 00:00 [revised]
PHST- 2021/09/09 00:00 [received]
PHST- 2021/12/16 00:00 [accepted]
PHST- 2022/01/09 06:00 [pubmed]
PHST- 2022/03/15 06:00 [medline]
PHST- 2022/01/08 06:17 [entrez]
AID - 10.1111/echo.15288 [doi]
PST - ppublish
SO  - Echocardiography. 2022 Feb;39(2):194-203. doi: 10.1111/echo.15288. Epub 2022 Jan 
      7.