PMID- 34998165
OWN - NLM
STAT- MEDLINE
DCOM- 20220404
LR  - 20220405
IS  - 1532-3072 (Electronic)
IS  - 0040-8166 (Linking)
VI  - 75
DP  - 2022 Apr
TI  - Imperatorin attenuates cardiac remodelling and dysfunction in 
      high-fat/high-fructose diet-fed rats by modulating oxidative stress, 
      inflammation, and Nrf-2 expression.
PG  - 101728
LID - S0040-8166(21)00244-5 [pii]
LID - 10.1016/j.tice.2021.101728 [doi]
AB  - Imperatorin, an active natural furocoumarin, exerts a wide range of biological 
      activities. In the present study, the therapeutic effects of imperatorin on 
      cardiac function and remodelling and the possible underlying mechanisms involved 
      in high-fat/high-fructose diet (HFFD)-fed rats were investigated. Male 
      Sprague-Dawley rats were fed a high-fat diet plus 15 % fructose in drinking water 
      for 16 weeks. HFFD-fed rats were treated with imperatorin (15 or 30 mg/kg/day) 
      for the last 4 weeks. Treatment of HFFD-fed rats with imperatorin significantly 
      reduced dyslipidaemia, hyperinsulinaemia, and hypertension. Imperatorin markedly 
      alleviated HFFD-induced cardiac morphology alterations and left ventricular (LV) 
      dysfunction. Imperatorin also significantly decreased malondialdehyde 
      concentration and increased catalase activity in plasma and cardiac tissue. 
      Additionally, decreased plasma tumour necrosis factor-alpha and interleukin-6 
      concentrations, together with restoration of cardiac nuclear factor-erythroid 
      2-related factor 2 (Nrf-2) protein expression, were also observed after treatment 
      with imperatorin. These findings indicated that imperatorin alleviates 
      HFFD-induced cardiac remodelling and LV dysfunction in rats. The possible 
      underlying mechanism may involve the reduction of oxidative stress and 
      inflammation, and the restoration of Nrf-2 expression.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Prasartthong, Patoomporn
AU  - Prasartthong P
AD  - Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 
      40002, Thailand.
FAU - Pakdeechote, Poungrat
AU  - Pakdeechote P
AD  - Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 
      40002, Thailand; Research Institute for Human High Performance and Health 
      Promotion, Khon Kaen University, Khon Kaen, 40002, Thailand.
FAU - Maneesai, Putcharawipa
AU  - Maneesai P
AD  - Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 
      40002, Thailand.
FAU - Meephat, Sariya
AU  - Meephat S
AD  - Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 
      40002, Thailand.
FAU - Rattanakanokchai, Siwayu
AU  - Rattanakanokchai S
AD  - Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
FAU - Wunpathe, Chutamas
AU  - Wunpathe C
AD  - Department of Basic Medical Science, Faculty of Medicine Vajira Hospital, 
      Navamindradhiraj University, Bangkok, 10300, Thailand.
FAU - Apaijit, Kwanjit
AU  - Apaijit K
AD  - Faculty of Medicine, Mahasarakham University, Maha Sarakham, 44000, Thailand.
FAU - Bunbupha, Sarawoot
AU  - Bunbupha S
AD  - Faculty of Medicine, Mahasarakham University, Maha Sarakham, 44000, Thailand. 
      Electronic address: sarawoot.b@msu.ac.th.
LA  - eng
PT  - Journal Article
DEP - 20220104
PL  - Scotland
TA  - Tissue Cell
JT  - Tissue & cell
JID - 0214745
RN  - 0 (Furocoumarins)
RN  - 30237-26-4 (Fructose)
RN  - K713N25C78 (imperatorin)
SB  - IM
MH  - Animals
MH  - *Diet, High-Fat/adverse effects
MH  - Fructose/adverse effects
MH  - *Furocoumarins/pharmacology
MH  - Inflammation/drug therapy/metabolism
MH  - Male
MH  - Oxidative Stress
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Ventricular Remodeling
OTO - NOTNLM
OT  - High-fat/high-fructose diet
OT  - Imperatorin
OT  - Inflammation
OT  - Nuclear factor-erythroid 2-related factor 2
OT  - Oxidative stress
EDAT- 2022/01/09 06:00
MHDA- 2022/04/05 06:00
CRDT- 2022/01/08 20:14
PHST- 2021/09/28 00:00 [received]
PHST- 2021/12/03 00:00 [revised]
PHST- 2021/12/31 00:00 [accepted]
PHST- 2022/01/09 06:00 [pubmed]
PHST- 2022/04/05 06:00 [medline]
PHST- 2022/01/08 20:14 [entrez]
AID - S0040-8166(21)00244-5 [pii]
AID - 10.1016/j.tice.2021.101728 [doi]
PST - ppublish
SO  - Tissue Cell. 2022 Apr;75:101728. doi: 10.1016/j.tice.2021.101728. Epub 2022 Jan 
      4.