PMID- 34998240
OWN - NLM
STAT- MEDLINE
DCOM- 20220413
LR  - 20220413
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 434
DP  - 2022 Mar 15
TI  - Visuomotor integration in early Alzheimer's disease: A TMS study.
PG  - 120129
LID - S0022-510X(21)02836-7 [pii]
LID - 10.1016/j.jns.2021.120129 [doi]
AB  - BACKGROUND AND PURPOSE: Cortical visuomotor integration is altered in Alzheimer's 
      disease (AD), even at an early stage of the disease. The aim of this study was to 
      assess the connections between the primary visual (V1) and motor (M1) areas in 
      patients with early AD using a paired-pulse, twin-coil transcranial magnetic 
      stimulation (TMS) technique. METHODS: Visuomotor connections (VMCs) were assessed 
      in 13 subjects with probable AD and 16 healthy control subjects. A conditioning 
      stimulus over the V1 phosphene hotspot was followed at interstimulus intervals 
      (ISIs) of 18 and 40 ms by a test stimulus over M1, to elicit motor evoked 
      potentials (MEPs) in the contralateral first dorsal interosseous muscle. RESULTS: 
      Significant effects due to VMCs, consisting of enhanced MEP suppression at ISI of 
      18 and 40 ms, were observed in the AD patients. Patients with AD showed an 
      excessive inhibitory response of the right M1 to inputs travelling from V1 at 
      given ISIs. CONCLUSIONS: This study provides neurophysiological evidence of 
      altered functional connectivity between visual and motor areas in AD.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Nardone, Raffaele
AU  - Nardone R
AD  - Department of Neurology, Hospital of Merano (SABES-ASDAA), Merano-Meran, Italy; 
      Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, 
      Salzburg, Austria; Spinal Cord Injury and Tissue Regeneration Center, Salzburg, 
      Austria; Karl Landsteiner Institut fur Neurorehabilitation und 
      Raumfahrtneurologie, Salzburg, Austria. Electronic address: 
      raffaele.nardone@asbmeran-o.it.
FAU - Langthaler, Patrick B
AU  - Langthaler PB
AD  - Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, 
      Salzburg, Austria; Department of Mathematics, Paris Lodron University of 
      Salzburg, Austria.
FAU - Schwenker, Kerstin
AU  - Schwenker K
AD  - Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, 
      Salzburg, Austria; Spinal Cord Injury and Tissue Regeneration Center, Salzburg, 
      Austria; Karl Landsteiner Institut fur Neurorehabilitation und 
      Raumfahrtneurologie, Salzburg, Austria.
FAU - Kunz, Alexander B
AU  - Kunz AB
AD  - Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, 
      Salzburg, Austria.
FAU - Sebastianelli, Luca
AU  - Sebastianelli L
AD  - Department of Neurorehabilitation, Hospital of Vipiteno (SABES-ASDAA), 
      Vipiteno-Sterzing, Italy.
FAU - Saltuari, Leopold
AU  - Saltuari L
AD  - Department of Neurorehabilitation, Hospital of Vipiteno (SABES-ASDAA), 
      Vipiteno-Sterzing, Italy.
FAU - Trinka, Eugen
AU  - Trinka E
AD  - Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, 
      Salzburg, Austria; Karl Landsteiner Institut fur Neurorehabilitation und 
      Raumfahrtneurologie, Salzburg, Austria; Centre for Cognitive Neuroscience 
      Salzburg, Salzburg, Austria; University for Medical Informatics and Health 
      Technology, UMIT, Hall in Tirol, Austria.
FAU - Versace, Viviana
AU  - Versace V
AD  - Department of Neurorehabilitation, Hospital of Vipiteno (SABES-ASDAA), 
      Vipiteno-Sterzing, Italy.
LA  - eng
PT  - Journal Article
DEP - 20220103
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
SB  - IM
MH  - *Alzheimer Disease
MH  - Electromyography
MH  - Evoked Potentials, Motor/physiology
MH  - Humans
MH  - *Motor Cortex
MH  - Transcranial Magnetic Stimulation
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Motor cortex
OT  - Transcranial magnetic stimulation
OT  - Visual cortex
OT  - Visuomotor connections
OT  - Visuomotor integration
EDAT- 2022/01/09 06:00
MHDA- 2022/04/14 06:00
CRDT- 2022/01/08 20:18
PHST- 2021/09/20 00:00 [received]
PHST- 2021/12/26 00:00 [revised]
PHST- 2021/12/28 00:00 [accepted]
PHST- 2022/01/09 06:00 [pubmed]
PHST- 2022/04/14 06:00 [medline]
PHST- 2022/01/08 20:18 [entrez]
AID - S0022-510X(21)02836-7 [pii]
AID - 10.1016/j.jns.2021.120129 [doi]
PST - ppublish
SO  - J Neurol Sci. 2022 Mar 15;434:120129. doi: 10.1016/j.jns.2021.120129. Epub 2022 
      Jan 3.