PMID- 34998411
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220113
IS  - 1743-7075 (Print)
IS  - 1743-7075 (Electronic)
IS  - 1743-7075 (Linking)
VI  - 19
IP  - 1
DP  - 2022 Jan 8
TI  - Edible red seaweed Campylaephora hypnaeoides J. Agardh alleviates obesity and 
      related metabolic disorders in mice by suppressing oxidative stress and 
      inflammatory response.
PG  - 4
LID - 10.1186/s12986-021-00633-5 [doi]
LID - 4
AB  - BACKGROUND: The obesity epidemic has become a serious public health problem in 
      many countries worldwide. Seaweed has few calories and is rich in active 
      nutritional components necessary for health promotion and disease prevention. The 
      aim of this study was to investigate the effects of the Campylaephora hypnaeoides 
      J. Agardh (C. hypnaeoides), an edible seaweed traditionally eaten in Japan, on 
      high-fat (HF) diet-induced obesity and related metabolic diseases in mice. 
      METHODS: Male C57BL/6J mice were randomly divided into the following groups: 
      normal diet group, HF diet group, HF diet supplemented with 2% C. hypnaeoides, 
      and HF diet supplemented with 6% C. hypnaeoides. After 13 weeks of treatment, the 
      weight of the white adipose tissue and liver, and the serum levels of glucose, 
      insulin, adipokines, and lipids were measured. Hepatic levels of adipokines, 
      oxidant markers, and antioxidant markers were also determined. Insulin resistance 
      was assessed by a glucose tolerance test. Polysaccharides of C. hypnaeoides were 
      purified and their molecular weight was determined by high-performance seize 
      exclusion chromatography. The anti-inflammatory effects of purified 
      polysaccharides were evaluated in RAW264.7 cells. RESULTS: Treatment of HF 
      diet-induced obese mice with C. hypnaeoides for 13 weeks suppressed the increase 
      in body weight and white adipose tissue weight. It also ameliorated insulin 
      resistance, hyperglycemia, hepatic steatosis, and hypercholesterolemia. The 
      ingestion of an HF diet increased serum levels of malondialdehyde (MDA), tumor 
      necrosis factor alpha (TNF-alpha), and monocyte chemoattractant protein-1 (MCP-1), while 
      it decreased serum adiponectin levels. In the liver, an HF diet markedly 
      increased the MDA, TNF-alpha, and interleukin-6 (IL-6) levels, while it decreased 
      glutathione and superoxide dismutase. These metabolic changes induced by HF diet 
      feeding were ameliorated by dietary C. hypnaeoides. Purified polysaccharides and 
      ethanol extract from C. hypnaeoides inhibited the lipopolysaccharide-induced 
      overproduction of nitric oxide and TNF-alpha in macrophage RAW264.7 cells. 
      CONCLUSIONS: The present results indicated that C. hypnaeoides was able to 
      alleviate HF diet-induced metabolic disorders, including obesity, hyperglycemia, 
      hepatic steatosis, and hypercholesterolemia by attenuating inflammation and 
      improving the antioxidant capacity in mice. Polysaccharides and polyphenols may 
      be involved in these beneficial effects of C. hypnaeoides.
CI  - (c) 2021. The Author(s).
FAU - Murakami, Shigeru
AU  - Murakami S
AUID- ORCID: 0000-0001-6062-5561
AD  - Department of Bioscience and Biotechnology, Fukui Prefectural University, Fukui, 
      9101195, Japan. murakami@fpu.ac.jp.
FAU - Hirazawa, Chihiro
AU  - Hirazawa C
AD  - Department of Bioscience and Biotechnology, Fukui Prefectural University, Fukui, 
      9101195, Japan.
FAU - Yoshikawa, Rina
AU  - Yoshikawa R
AD  - Department of Bioscience and Biotechnology, Fukui Prefectural University, Fukui, 
      9101195, Japan.
FAU - Mizutani, Toshiki
AU  - Mizutani T
AD  - Department of Bioscience and Biotechnology, Fukui Prefectural University, Fukui, 
      9101195, Japan.
FAU - Ohya, Takuma
AU  - Ohya T
AD  - Department of Bioscience and Biotechnology, Fukui Prefectural University, Fukui, 
      9101195, Japan.
FAU - Ma, Ning
AU  - Ma N
AD  - Division of Health Science, Graduate School of Health Science, Suzuka University, 
      Mie, 5100293, Japan.
FAU - Ikemori, Takahiko
AU  - Ikemori T
AD  - Ishikawa Prefecture Fisheries Division, Ishikawa, 9208580, Japan.
FAU - Ito, Takashi
AU  - Ito T
AD  - Department of Bioscience and Biotechnology, Fukui Prefectural University, Fukui, 
      9101195, Japan.
FAU - Matsuzaki, Chiaki
AU  - Matsuzaki C
AD  - Research Institute for Bioscience and Biotechnology, Ishikawa Prefectural 
      University, Ishikawa, 9218836, Japan.
LA  - eng
GR  - 01-02R010201/Fukui Kenritsu Daigaku/
PT  - Journal Article
DEP - 20220108
PL  - England
TA  - Nutr Metab (Lond)
JT  - Nutrition & metabolism
JID - 101231644
PMC - PMC8742934
OTO - NOTNLM
OT  - Campylaephora hypnaeoides J. Agardh
OT  - Diabetes
OT  - Hepatic steatosis
OT  - Inflammation
OT  - Obesity
OT  - Oxidative stress
OT  - Polysaccharide
OT  - Seaweed
COIS- The authors declare no competing interest in association with the present study.
EDAT- 2022/01/10 06:00
MHDA- 2022/01/10 06:01
PMCR- 2022/01/08
CRDT- 2022/01/09 20:29
PHST- 2021/09/13 00:00 [received]
PHST- 2021/11/30 00:00 [accepted]
PHST- 2022/01/09 20:29 [entrez]
PHST- 2022/01/10 06:00 [pubmed]
PHST- 2022/01/10 06:01 [medline]
PHST- 2022/01/08 00:00 [pmc-release]
AID - 10.1186/s12986-021-00633-5 [pii]
AID - 633 [pii]
AID - 10.1186/s12986-021-00633-5 [doi]
PST - epublish
SO  - Nutr Metab (Lond). 2022 Jan 8;19(1):4. doi: 10.1186/s12986-021-00633-5.