PMID- 34998723
OWN - NLM
STAT- MEDLINE
DCOM- 20220517
LR  - 20220530
IS  - 1538-2990 (Electronic)
IS  - 0002-9629 (Linking)
VI  - 363
IP  - 6
DP  - 2022 Jun
TI  - Diagnostic value of endoscopic ultrasound for detecting pancreatic neuroendocrine 
      tumors: A systematic review and meta-analysis.
PG  - 511-518
LID - S0002-9629(21)00454-7 [pii]
LID - 10.1016/j.amjms.2021.10.026 [doi]
AB  - BACKGROUND: Endoscopic ultrasound (EUS) is widely used as a cost-effective method 
      for detecting pancreatic neuroendocrine tumors (PNTs), but its diagnostic value 
      is variable among published studies. This meta-analysis aimed to determine the 
      diagnostic value of EUS for PNTs. METHODS: Three electronic databases, including 
      PubMed, Embase, and the Cochrane Library, were searched for studies published up 
      to July 2018. The summary sensitivity, specificity, positive likelihood ratio 
      (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and receiver 
      operating characteristic (ROC) curve were calculated to evaluate the diagnostic 
      value of EUS using the random-effects model. RESULTS: Thirteen studies involving 
      609 patients were included in this meta-analysis. The summary sensitivity and 
      specificity of EUS for detecting PNTs were 0.86 and 0.89, respectively. The PLR 
      and NLR of EUS were 7.81 and 0.15, respectively. The DOR of EUS for diagnosing 
      PNTs was 24.20. The area under the ROC was 0.90. Finally, the subgroup analyses 
      indicated that publication year and percentage of males could introduce potential 
      biases for the DOR of EUS. CONCLUSIONS: This meta-analysis suggests that EUS has 
      a relatively high diagnostic value for diagnosing PNTs.
CI  - Copyright (c) 2022 Southern Society for Clinical Investigation. Published by 
      Elsevier Inc. All rights reserved.
FAU - Chen, Yang
AU  - Chen Y
AD  - Department of General Surgery, The Seventh Affiliated Hospital of Sun Yat-Sen 
      University (ShenZhen), Shen Zhen, China.
FAU - Huang, Fei
AU  - Huang F
AD  - Department of General Surgery, The Seventh Affiliated Hospital of Sun Yat-Sen 
      University (ShenZhen), Shen Zhen, China.
FAU - Fan, Youwen
AU  - Fan Y
AD  - Department of General Surgery, The Seventh Affiliated Hospital of Sun Yat-Sen 
      University (ShenZhen), Shen Zhen, China.
FAU - Li, Dong
AU  - Li D
AD  - Department of General Surgery, The Seventh Affiliated Hospital of Sun Yat-Sen 
      University (ShenZhen), Shen Zhen, China.
FAU - Tao, Qiang
AU  - Tao Q
AD  - Department of General Surgery, The Seventh Affiliated Hospital of Sun Yat-Sen 
      University (ShenZhen), Shen Zhen, China.
FAU - Tang, Di
AU  - Tang D
AD  - Department of General Surgery, The Seventh Affiliated Hospital of Sun Yat-Sen 
      University (ShenZhen), Shen Zhen, China. Electronic address: vassonhuang@163.com.
FAU - Deng, Liang
AU  - Deng L
AD  - Department of General Surgery, The Seventh Affiliated Hospital of Sun Yat-Sen 
      University (ShenZhen), Shen Zhen, China.
FAU - Ma, Chao
AU  - Ma C
AD  - Department of Anesthesiology, The Seventh Affiliated Hospital Of Sun Yat-Sen 
      University (ShenZhen), Shen Zhen, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20220106
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
SB  - IM
MH  - Endosonography
MH  - Humans
MH  - Male
MH  - *Neuroendocrine Tumors/diagnostic imaging
MH  - *Pancreatic Neoplasms/diagnostic imaging/pathology
MH  - ROC Curve
MH  - Sensitivity and Specificity
OTO - NOTNLM
OT  - Detect
OT  - Diagnosis
OT  - Endoscopic ultrasound
OT  - Meta-analysis
OT  - Pancreatic neuroendocrine tumors
EDAT- 2022/01/10 06:00
MHDA- 2022/05/18 06:00
CRDT- 2022/01/09 20:40
PHST- 2020/06/01 00:00 [received]
PHST- 2021/05/07 00:00 [revised]
PHST- 2021/10/21 00:00 [accepted]
PHST- 2022/01/10 06:00 [pubmed]
PHST- 2022/05/18 06:00 [medline]
PHST- 2022/01/09 20:40 [entrez]
AID - S0002-9629(21)00454-7 [pii]
AID - 10.1016/j.amjms.2021.10.026 [doi]
PST - ppublish
SO  - Am J Med Sci. 2022 Jun;363(6):511-518. doi: 10.1016/j.amjms.2021.10.026. Epub 
      2022 Jan 6.