PMID- 34999026
OWN - NLM
STAT- MEDLINE
DCOM- 20220401
LR  - 20220531
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 208
DP  - 2022 May 15
TI  - Attention deficit among preschool and school-aged children living near former 
      metal-processing plants in Romania.
PG  - 112689
LID - S0013-9351(22)00016-0 [pii]
LID - 10.1016/j.envres.2022.112689 [doi]
AB  - Industrial areas affected by high and long-term heavy metal pollution have a 
      great impact on health of the resident population. Children represent a group at 
      high-risk with an increased susceptibility to chronic heavy metal intoxication. 
      Our work included the assessment of attention particularities through a 
      case-control study in pre-school and school-aged children (4-6 years and 8-11 
      years) from two study areas, Copsa Mica and Zlatna, compared to a non-polluted 
      locality with no history of heavy metal pollution. Copsa Mica and Zlatna are two 
      of the most polluted heavy metals regions in Romania due to non-ferrous 
      metallurgy for a long period of time. Recruitment of participants was made by a 
      random selection of an entire class for each age within the schools and 
      kindergartens from the study areas (Copsa Mica and Zlatna) and from the 
      non-polluted region. Interpretation of data was performed using statistical 
      analysis (ANOVA and Student's t-test). Preschool children (4-6 years) were tested 
      using Wechsler Preschool and Primary Scale of Intelligence (WPPSI) tests, Animal 
      House and labyrinth samples. The results of the attention tests applied to 
      pre-school children were lower in the study areas compared to the control group, 
      but no statistical differences were found. The results of the attention tests 
      applied to children aged between 8 and 11 years (Toulouse-Pieron test and Traffic 
      light test) indicate lower average scores within the study groups from polluted 
      areas, compared to the control group. Differences with statistically significance 
      were registered for the 8 years age group (p = 0.037). In these areas efficient 
      strategies and precise intervention measures are needed in order to limit or 
      remove the heavy metal exposure and protect the human health, especially the 
      groups exposed to a high level of risk.
CI  - Copyright (c) 2022. Published by Elsevier Inc.
FAU - Nedelescu, Mirela
AU  - Nedelescu M
AD  - (")Carol Davila" University of Medicine and Pharmacy, Faculty of Medicine, 8 
      Eroii Sanitari Blvd, Bucharest, Romania; National Institute of Public Health, 
      Department of Food Hygiene and Nutrition, 1-3 Dr. Leonte Street, Bucharest, 
      Romania.
FAU - Stan, Miriana
AU  - Stan M
AD  - "Carol Davila" University of Medicine and Pharmacy "Carol Davila", Faculty of 
      Pharmacy, 6 Traian Vuia Street, Bucharest, Romania. Electronic address: 
      miriana.stan@umfcd.ro.
FAU - Ciobanu, Anne-Marie
AU  - Ciobanu AM
AD  - "Carol Davila" University of Medicine and Pharmacy "Carol Davila", Faculty of 
      Pharmacy, 6 Traian Vuia Street, Bucharest, Romania.
FAU - Balalau, Cristian
AU  - Balalau C
AD  - (")Carol Davila" University of Medicine and Pharmacy, Faculty of Medicine, 8 
      Eroii Sanitari Blvd, Bucharest, Romania.
FAU - Filippini, Tommaso
AU  - Filippini T
AD  - CREAGEN - Environmental, Genetic and Nutritional Epidemiology Research Center, 
      Department of Biomedical, Metabolic and Neural Sciences, University of Modena and 
      Reggio Emilia, Via Campi 287, Modena, Italy.
FAU - Baconi, Daniela
AU  - Baconi D
AD  - "Carol Davila" University of Medicine and Pharmacy "Carol Davila", Faculty of 
      Pharmacy, 6 Traian Vuia Street, Bucharest, Romania.
LA  - eng
PT  - Journal Article
DEP - 20220107
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Metals, Heavy)
SB  - IM
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - *Environmental Monitoring
MH  - Environmental Pollution/analysis
MH  - Humans
MH  - *Metals, Heavy/analysis
MH  - Romania/epidemiology
OTO - NOTNLM
OT  - Attention tests
OT  - Children
OT  - Heavy metals
OT  - Lead exposure
OT  - Neurotoxicity
EDAT- 2022/01/10 06:00
MHDA- 2022/04/02 06:00
CRDT- 2022/01/09 20:45
PHST- 2021/08/11 00:00 [received]
PHST- 2021/12/14 00:00 [revised]
PHST- 2022/01/04 00:00 [accepted]
PHST- 2022/01/10 06:00 [pubmed]
PHST- 2022/04/02 06:00 [medline]
PHST- 2022/01/09 20:45 [entrez]
AID - S0013-9351(22)00016-0 [pii]
AID - 10.1016/j.envres.2022.112689 [doi]
PST - ppublish
SO  - Environ Res. 2022 May 15;208:112689. doi: 10.1016/j.envres.2022.112689. Epub 2022 
      Jan 7.