PMID- 34999341
OWN - NLM
STAT- Publisher
LR  - 20231013
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 230
DP  - 2022 Jan 15
TI  - Combined effects of exposure to polycyclic aromatic hydrocarbons and metals on 
      oxidative stress among healthy adults in Caofeidian, China.
PG  - 113168
LID - S0147-6513(22)00008-2 [pii]
LID - 10.1016/j.ecoenv.2022.113168 [doi]
AB  - Exposure to polycyclic aromatic hydrocarbons (PAHs) and metals is associated with 
      many adverse effects on human health, accompanied by oxidative stress. This study 
      aimed to investigate the effects of co-exposure to PAHs and metals on oxidative 
      stress in healthy adults. A preliminary longitudinal panel study was conducted 
      between 2017 and 2018 in 45 healthy college students in Caofeidian, China. Six 
      urinary monohydroxylated-PAHs (OH-PAHs), ten metals, 8-hydroxydeoxyguanosine 
      (8-OHdG), and 8-iso-prostaglandin-F2alpha (8-iso-PGF2alpha) were measured. Linear mixed 
      effects (LME) models and Bayesian kernel machine regression (BKMR) models were 
      used to explore the associations of urinary OH-PAHs and metals with 8-OHdG and 
      8-iso-PGF2alpha. LME models showed that most urinary OH-PAHs and metals were 
      positively associated with 8-OHdG and 8-iso-PGF2alpha. For example, a one-unit 
      increase in the ln-transformed level of 1-hydroxypyrene (1-OHPyr) and vanadium 
      (V) was associated with an increase of 143.8% (95% CI: 105.7 - 188.9%) and 105.8% 
      (95% CI: 79.2-136.4%) in 8-OHdG; 8-iso-PGF2alpha increased by 118.9% (95% CI: 
      99.2-140.5%) and 83.9% (95% CI: 67.2-102.2%) with a one-unit increase in the 
      ln-transformed level of 3-hydroxyphenanthrene (3-OHPhe) and aluminum (Al). BKMR 
      models indicated the overall positive associations of the mixture of six OH-PAHs, 
      ten metals, or six OH-PAHs and ten metals with 8-OHdG and 8-iso-PGF2alpha. Urinary 
      1-OHPyr and V were identified as the major contributors to the increased urinary 
      8-OHdG levels, while urinary 3-OHPhe and Al were the most vital contributors to 
      the increased urinary 8-iso-PGF2alpha levels. The results revealed the longitudinal 
      dose-response relationships of urinary OH-PAHs and metals with oxidative stress 
      among healthy adults in Caofeidian; this finding serves as an evidence regarding 
      the early health hazard caused by exposure to PAHs and metals and has 
      implications for the environmental management of PAH and metal emissions in this 
      area.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Zeng, Hao
AU  - Zeng H
AD  - School of Public Health, North China University of Science and Technology, No. 21 
      Bohai Road, Caofeidian, Tangshan 063210, Hebei, China.
FAU - Fang, Bo
AU  - Fang B
AD  - School of Public Health, North China University of Science and Technology, No. 21 
      Bohai Road, Caofeidian, Tangshan 063210, Hebei, China; Affiliated Huaihe 
      Hospital, Henan University, 115 Ximen Street, Kaifeng 475000, Henan, China.
FAU - Hao, Kelu
AU  - Hao K
AD  - School of Public Health, North China University of Science and Technology, No. 21 
      Bohai Road, Caofeidian, Tangshan 063210, Hebei, China.
FAU - Wang, Haotian
AU  - Wang H
AD  - School of Public Health, North China University of Science and Technology, No. 21 
      Bohai Road, Caofeidian, Tangshan 063210, Hebei, China.
FAU - Zhang, Lei
AU  - Zhang L
AD  - School of Public Health, North China University of Science and Technology, No. 21 
      Bohai Road, Caofeidian, Tangshan 063210, Hebei, China; Department of Occupational 
      Health and Environmental Health, School of Public Health, Capital Medical 
      University, Beijing 100069, China.
FAU - Wang, Manman
AU  - Wang M
AD  - School of Public Health, North China University of Science and Technology, No. 21 
      Bohai Road, Caofeidian, Tangshan 063210, Hebei, China.
FAU - Hao, Yulan
AU  - Hao Y
AD  - School of Public Health, North China University of Science and Technology, No. 21 
      Bohai Road, Caofeidian, Tangshan 063210, Hebei, China.
FAU - Wang, Xuesheng
AU  - Wang X
AD  - School of Public Health, North China University of Science and Technology, No. 21 
      Bohai Road, Caofeidian, Tangshan 063210, Hebei, China.
FAU - Wang, Qian
AU  - Wang Q
AD  - School of Public Health, North China University of Science and Technology, No. 21 
      Bohai Road, Caofeidian, Tangshan 063210, Hebei, China. Electronic address: 
      wwqq517@126.com.
FAU - Yang, Wenqi
AU  - Yang W
AD  - Affiliated Hospital, North China University of Science and Technology, Tangshan 
      063000, China. Electronic address: yangwenqi616@163.com.
FAU - Rong, Suying
AU  - Rong S
AD  - Department of Clinical Medicine, Tangshan Vocational and Technical College, No. 
      120 Xinhua West Road, Tangshan 063000, China.
LA  - eng
PT  - Journal Article
DEP - 20220106
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
SB  - IM
OTO - NOTNLM
OT  - Bayesian kernel machine regression
OT  - Caofeidian
OT  - Metals
OT  - Oxidative stress
OT  - Polycyclic aromatic hydrocarbons
EDAT- 2022/01/10 06:00
MHDA- 2022/01/10 06:00
CRDT- 2022/01/09 20:53
PHST- 2021/10/04 00:00 [received]
PHST- 2022/01/01 00:00 [revised]
PHST- 2022/01/03 00:00 [accepted]
PHST- 2022/01/10 06:00 [pubmed]
PHST- 2022/01/10 06:00 [medline]
PHST- 2022/01/09 20:53 [entrez]
AID - S0147-6513(22)00008-2 [pii]
AID - 10.1016/j.ecoenv.2022.113168 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2022 Jan 15;230:113168. doi: 
      10.1016/j.ecoenv.2022.113168. Epub 2022 Jan 6.