PMID- 3499954
OWN - NLM
STAT- MEDLINE
DCOM- 19871222
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 420
IP  - 2
DP  - 1987 Sep 15
TI  - Synaptic reorganization in the medial amygdaloid nucleus after lesion of the 
      accessory olfactory bulb of adult rat. II. New synapse formation in the medial 
      amygdaloid nucleus by fibers from the bed nucleus of the stria terminalis.
PG  - 253-8
AB  - The rearrangement of terminations from the bed nucleus of stria terminalis (BST) 
      was examined in the medial amygdaloid nucleus (MAN) at 2 months following the 
      lesion of the accessory olfactory bulb (AOB) using an electron microscopy and 
      degeneration study. At 2 days following a BST lesion, the number of degenerating 
      synapses was 0.7 +/- 0.1 (mean +/- S.E.M.) per unit area (2500 microns2) in the 
      molecular layer, and 3.0 +/- 0.3 in the cellular part. At 2 months after an AOB 
      lesion, the degenerating synapses from the AOB had completely disappeared from 
      the MAN. The BST was then lesioned at 2 months after the AOB lesion and, at 2 
      days following this BST lesion, the degenerating synapses were counted in MAN. 
      The numbers observed were 3.3 +/- 0.6 per unit area in the molecular layer and 
      4.5 +/- 0.4 in the cellular part. Therefore, the number of these degenerating 
      synapses increased significantly within the molecular layer, though, in the 
      cellular part the number of synapses was not significantly elevated over control. 
      No differences in postsynaptic profiles (ratio of synapses on dendritic spine to 
      dendritic shaft) were observed after the AOB lesion. These results indicate that 
      the BST fibers formed new synapses in the molecular layer following the 
      denervation of AOB fibers. The possibility of new synapse formation by other 
      afferent fibers in addition to the AOB fibers is discussed as is the relationship 
      between lesion induced synaptic reorganization and functional recovery after 
      injury.
FAU - Ichikawa, M
AU  - Ichikawa M
AD  - Department of Anatomy and Embryology, Tokyo Metropolitan Institute for 
      Neurosciences, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
SB  - IM
MH  - Amygdala/cytology/*physiology
MH  - Animals
MH  - Cell Count
MH  - Male
MH  - Medial Forebrain Bundle/cytology/*physiology
MH  - Nerve Degeneration
MH  - Nerve Fibers/physiology
MH  - Neural Pathways/*physiology
MH  - *Neuronal Plasticity
MH  - Olfactory Bulb/*physiology
MH  - Rats
MH  - Synapses/*physiology
MH  - Time Factors
EDAT- 1987/09/15 00:00
MHDA- 1987/09/15 00:01
CRDT- 1987/09/15 00:00
PHST- 1987/09/15 00:00 [pubmed]
PHST- 1987/09/15 00:01 [medline]
PHST- 1987/09/15 00:00 [entrez]
AID - 0006-8993(87)91245-5 [pii]
AID - 10.1016/0006-8993(87)91245-5 [doi]
PST - ppublish
SO  - Brain Res. 1987 Sep 15;420(2):253-8. doi: 10.1016/0006-8993(87)91245-5.