PMID- 35004886
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220111
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 8
DP  - 2021
TI  - Integrated Aortic-Valve-And-Ascending-Aortic Replacement vs. Partial Replacement 
      in Bicuspid Aortic Valve-Related Aortopathy.
PG  - 771346
LID - 10.3389/fcvm.2021.771346 [doi]
LID - 771346
AB  - Objective: We sought to evaluate the outcomes of integrated aortic-valve and 
      ascending-aortic replacement (IR) vs. partial replacement (PR) in patients with 
      bicuspid aortic valve (BAV)-related aortopathy. Methods: We compared long-term 
      mortality, reoperation incidence, and the cumulative incidence of stroke, 
      bleeding, significant native valve or prosthetic valve dysfunction, and the New 
      York Heart Association (NYHA) functional classes II-IV between inverse 
      probability-weighted cohorts of patients who underwent IR or PR for BAV-related 
      aortopathy in a single center from 2002 to 2019. Patients were stratified into 
      different aortic diameter groups ("valve type" vs. "aorta type"). Results: Among 
      patients with "valve type," aortic valve replacement in patients with an aortic 
      diameter > 40 mm was associated with significantly higher 10-year mortality than 
      IR compared with diameter 35-40 mm [17.49 vs. 5.28% at 10 years; hazard ratio 
      (HR), 3.22; 95% CI, 1.52 to 6.85; p = 0.002]. Among patients with "aorta type," 
      ascending aortic replacement in patients with an aortic diameter 52-60 mm was 
      associated with significantly higher 10-year mortality than IR compared with 
      diameter 45-52 mm (14.49 vs. 1.85% at 10 years; HR, 0.04; 95% CI, 1.06 to 85.24; 
      p = 0.03). Conclusion: The long-term mortality and reoperation benefit that were 
      associated with IR, as compared with PR, minimizing to 40 mm of the aortic 
      diameter among patients with "valve type" and minimizing to 52 mm of the aortic 
      diameter among patients with "aorta type." Trial Registration: Treatment to 
      Bicuspid Aortic Valve Related Aortopathy (BAVAo Registry): ChiCTR.org.cn no: 
      ChiCTR2000039867.
CI  - Copyright (c) 2021 Chen, Xu, Ding, Zhao, Wang, Yang, Qiao, Zhang, Zhou, Jia, Bai, 
      Xue, Zhu, Liu, Li and Sun.
FAU - Chen, Mi
AU  - Chen M
AD  - Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, China.
AD  - Department of Cardiac Surgery, University Hospital of Zurich, University of 
      Zurich, Zurich, Switzerland.
FAU - Xu, Wangli
AU  - Xu W
AD  - Center for Applied Statistics and School of Statistics, Renmin University of 
      China, Beijing, China.
FAU - Ding, Yan
AU  - Ding Y
AD  - Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, China.
FAU - Zhao, Honglei
AU  - Zhao H
AD  - Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, China.
FAU - Wang, Pei
AU  - Wang P
AD  - Center for Applied Statistics and School of Statistics, Renmin University of 
      China, Beijing, China.
FAU - Yang, Bo
AU  - Yang B
AD  - Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, China.
FAU - Qiao, Huanyu
AU  - Qiao H
AD  - Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, China.
FAU - Zhou, Chenyang
AU  - Zhou C
AD  - Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, China.
FAU - Jia, Junnan
AU  - Jia J
AD  - National Tuberculosis (TB) Clinical Lab, Beijing Chest Hospital, Capital Medical 
      University, Beijing, China.
FAU - Bai, Tao
AU  - Bai T
AD  - Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, China.
FAU - Xue, Jinrong
AU  - Xue J
AD  - Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, China.
FAU - Zhu, Junming
AU  - Zhu J
AD  - Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, China.
FAU - Liu, Yongmin
AU  - Liu Y
AD  - Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, China.
FAU - Li, Weimin
AU  - Li W
AD  - National Tuberculosis (TB) Clinical Lab, Beijing Chest Hospital, Capital Medical 
      University, Beijing, China.
FAU - Sun, Lizhong
AU  - Sun L
AD  - Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20211222
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC8727738
OTO - NOTNLM
OT  - aneurysm
OT  - aortic dilatation
OT  - aortopathy
OT  - bicuspid aortic valve
OT  - bicuspid aortic valve-related aortopathy
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/01/11 06:00
MHDA- 2022/01/11 06:01
PMCR- 2021/01/01
CRDT- 2022/01/10 09:27
PHST- 2021/09/06 00:00 [received]
PHST- 2021/11/23 00:00 [accepted]
PHST- 2022/01/10 09:27 [entrez]
PHST- 2022/01/11 06:00 [pubmed]
PHST- 2022/01/11 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2021.771346 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2021 Dec 22;8:771346. doi: 10.3389/fcvm.2021.771346. 
      eCollection 2021.