PMID- 35006902
OWN - NLM
STAT- MEDLINE
DCOM- 20220408
LR  - 20220408
IS  - 2576-6422 (Electronic)
IS  - 2576-6422 (Linking)
VI  - 4
IP  - 8
DP  - 2021 Aug 16
TI  - Rapid Analysis of Biological Samples Using Monolithic Polymer-Based In-Tube 
      Solid-Phase Microextraction with Direct Mass Spectrometry.
PG  - 6236-6243
LID - 10.1021/acsabm.1c00551 [doi]
AB  - Online coupling in-tube solid-phase microextraction (SPME) with mass spectrometry 
      (MS) was achieved by directly utilizing a monolithic SPME capillary as the 
      electrospray emitter. A porous organic polymer with a highly porous structure can 
      not only provide excellent extraction efficiency due to its high specific surface 
      area but also increase the ionization efficiency and stability by producing 
      smaller electrospray droplets. This online coupling strategy significantly 
      simplifies the device as well as the operation process. The whole analytical 
      process only takes about 12 min with a sample amount of 100 muL. By choosing an 
      ionic liquid-based organic polymer with high extraction ability and good 
      stability and adjusting a suitable porous structure for better electrospray, the 
      developed in-tube SPME-MS method showed excellent extraction performance and good 
      reusability without clogging events. As a proof of concept, the proposed method 
      was applied for the analysis of non-steroid anti-inflammatory drugs in plasma and 
      urine samples. The method showed a wide linear range (0.1-200 ng/mL), good 
      linearity (R(2) >/= 0.99), and good reproducibility (intra-day relative standard 
      deviations (RSDs) <3.00% and inter-day RSDs <6.29%).
FAU - Hu, Wei
AU  - Hu W
AD  - Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of 
      Education, Hubei Province Engineering and Technology Research Center for 
      Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, 
      No. 185 Donghu Road, Wuchang District, Wuhan 430071, China.
AD  - State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, 
      Beijing 100080, China.
FAU - Zhou, Wei
AU  - Zhou W
AD  - Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of 
      Education, Hubei Province Engineering and Technology Research Center for 
      Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, 
      No. 185 Donghu Road, Wuchang District, Wuhan 430071, China.
AD  - State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, 
      Beijing 100080, China.
FAU - Wang, Chenlu
AU  - Wang C
AD  - Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of 
      Education, Hubei Province Engineering and Technology Research Center for 
      Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, 
      No. 185 Donghu Road, Wuchang District, Wuhan 430071, China.
FAU - Liu, Zichun
AU  - Liu Z
AD  - Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of 
      Education, Hubei Province Engineering and Technology Research Center for 
      Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, 
      No. 185 Donghu Road, Wuchang District, Wuhan 430071, China.
FAU - Chen, Zilin
AU  - Chen Z
AUID- ORCID: 0000-0001-9824-9987
AD  - Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of 
      Education, Hubei Province Engineering and Technology Research Center for 
      Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, 
      No. 185 Donghu Road, Wuchang District, Wuhan 430071, China.
AD  - State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, 
      Beijing 100080, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210714
PL  - United States
TA  - ACS Appl Bio Mater
JT  - ACS applied bio materials
JID - 101729147
RN  - 0 (Ionic Liquids)
RN  - 0 (Polymers)
SB  - IM
MH  - *Ionic Liquids
MH  - Polymers/chemistry
MH  - Reproducibility of Results
MH  - *Solid Phase Microextraction/methods
MH  - Tandem Mass Spectrometry/methods
OTO - NOTNLM
OT  - direct mass spectrometry
OT  - electrospray emitter
OT  - human plasma
OT  - human urine
OT  - monolithic polymer
OT  - non-steroid anti-inflammatory drugs
OT  - solid-phase microexraction
EDAT- 2022/01/11 06:00
MHDA- 2022/04/09 06:00
CRDT- 2022/01/10 17:13
PHST- 2022/01/10 17:13 [entrez]
PHST- 2022/01/11 06:00 [pubmed]
PHST- 2022/04/09 06:00 [medline]
AID - 10.1021/acsabm.1c00551 [doi]
PST - ppublish
SO  - ACS Appl Bio Mater. 2021 Aug 16;4(8):6236-6243. doi: 10.1021/acsabm.1c00551. Epub 
      2021 Jul 14.