PMID- 35006903
OWN - NLM
STAT- MEDLINE
DCOM- 20220408
LR  - 20220408
IS  - 2576-6422 (Electronic)
IS  - 2576-6422 (Linking)
VI  - 4
IP  - 8
DP  - 2021 Aug 16
TI  - Facile Multistep Synthesis of ZnO-Coated beta-NaYF(4):Yb/Tm Upconversion 
      Nanoparticles as an Antimicrobial Photodynamic Therapy for Persistent 
      Staphylococcus aureus Small Colony Variants.
PG  - 6125-6136
LID - 10.1021/acsabm.1c00473 [doi]
AB  - Antibacterial treatment strategies using functional nanomaterials, such as 
      photodynamic therapy, are urgently required to combat persistent Staphylococcus 
      aureus small colony variant (SCV) bacteria. Using a stepwise approach involving 
      thermolysis to form beta-NaYF(4):Yb/Tm upconversion nanoparticles (UCNPs) and 
      surface ligand exchange with cetyltrimethylammonium bromide (CTAB), followed by 
      zeolite imidazolate framework-8 (ZIF-8) coating and conversion to zinc oxide 
      (ZnO), beta-NaYF(4):Yb/Tm@ZnO nanoparticles were synthesized. The direct synthesis 
      of beta-NaYF(4):Yb/Tm@ZIF-8 UCNPs proved problematic due to the hydrophobic nature 
      of the as-synthesized material, which was shown by zeta potential measurements 
      using dynamic light scattering (DLS). To facilitate deposition of a ZnO coating, 
      the zeta potentials of (i) as-synthesized UCNPs, (ii) calcined UCNPs, (iii) 
      polyvinylpyrrolidone (PVP), and (iv) CTAB-coated UCNPs were measured, which 
      revealed the CTAB-coated UCNPs to be the most hydrophilic and the 
      better-dispersed form in water. beta-NaYF(4):Yb/Tm@ZIF-8 composites formed using the 
      CTAB-coated UCNPs were then converted into beta-NaYF(4):Yb/Tm@ZnO nanoparticles by 
      calcination under carefully controlled conditions. Photoluminescence analysis 
      confirmed the upconversion process for the UCNP core, which allows the 
      beta-NaYF(4):Yb/Tm@ZnO nanoparticles to photogenerate reactive oxygen species (ROS) 
      when activated by near-infrared (NIR) radiation. The NIR-activated UCNPs@ZnO 
      nanoparticles demonstrated potent efficacy against both Staphylococcus aureus 
      (WCH-SK2) and its associated SCV form (0.67 and 0.76 log colony forming unit 
      (CFU) reduction, respectively), which was attributed to ROS generated from the 
      NIR activated beta-NaYF(4):Yb/Tm@ZnO nanoparticles.
FAU - Karami, Afshin
AU  - Karami A
AUID- ORCID: 0000-0002-8881-4468
AD  - School of Chemical Engineering and Advanced Materials, The University of 
      Adelaide, Adelaide, South Australia 5005, Australia.
FAU - Farivar, Farzaneh
AU  - Farivar F
AD  - School of Chemical Engineering and Advanced Materials, The University of 
      Adelaide, Adelaide, South Australia 5005, Australia.
FAU - de Prinse, Thomas J
AU  - de Prinse TJ
AUID- ORCID: 0000-0002-4567-299X
AD  - Institute for Photonics and Advanced Sensing (IPAS), School of Physical Sciences, 
      The University of Adelaide, Adelaide, South Australia 5005, Australia.
FAU - Rabiee, Hesamoddin
AU  - Rabiee H
AD  - Advanced Water Management Centre, Faculty of Engineering, Architecture and 
      Information Technology, The University of Queensland, St. Lucia, Queensland 4072, 
      Australia.
FAU - Kidd, Stephen
AU  - Kidd S
AD  - Australian Centre for Antimicrobial Resistance Ecology, Research Centre for 
      Infectious Disease, School of Biological Sciences, The University of Adelaide, 
      Adelaide, South Australia 5005, Australia.
FAU - Sumby, Christopher J
AU  - Sumby CJ
AUID- ORCID: 0000-0002-9713-9599
AD  - Department of Chemistry and Centre for Advanced Nanomaterials, The University of 
      Adelaide, Adelaide, South Australia 5005, Australia.
FAU - Bi, Jingxiu
AU  - Bi J
AD  - School of Chemical Engineering and Advanced Materials, The University of 
      Adelaide, Adelaide, South Australia 5005, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210723
PL  - United States
TA  - ACS Appl Bio Mater
JT  - ACS applied bio materials
JID - 101729147
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Reactive Oxygen Species)
RN  - 1318-02-1 (Zeolites)
RN  - SOI2LOH54Z (Zinc Oxide)
RN  - Z7FF1XKL7A (Cetrimonium)
SB  - IM
MH  - Anti-Bacterial Agents/pharmacology
MH  - Cetrimonium
MH  - *Nanoparticles/therapeutic use
MH  - *Photochemotherapy
MH  - Reactive Oxygen Species
MH  - Staphylococcus aureus
MH  - *Zeolites
MH  - *Zinc Oxide/pharmacology
OTO - NOTNLM
OT  - CTAB
OT  - Staphylococcus aureus
OT  - ZIF-8
OT  - antibacterial
OT  - antimicrobial photodynamic therapy
OT  - small colony variants
OT  - upconversion nanomaterial
EDAT- 2022/01/11 06:00
MHDA- 2022/04/09 06:00
CRDT- 2022/01/10 17:13
PHST- 2022/01/10 17:13 [entrez]
PHST- 2022/01/11 06:00 [pubmed]
PHST- 2022/04/09 06:00 [medline]
AID - 10.1021/acsabm.1c00473 [doi]
PST - ppublish
SO  - ACS Appl Bio Mater. 2021 Aug 16;4(8):6125-6136. doi: 10.1021/acsabm.1c00473. Epub 
      2021 Jul 23.