PMID- 35006942
OWN - NLM
STAT- MEDLINE
DCOM- 20220408
LR  - 20220408
IS  - 2576-6422 (Electronic)
IS  - 2576-6422 (Linking)
VI  - 4
IP  - 9
DP  - 2021 Sep 20
TI  - pH and H(2)S Dual-Responsive Magnetic Metal-Organic Frameworks for Controlling 
      the Release of 5-Fluorouracil.
PG  - 7103-7110
LID - 10.1021/acsabm.1c00710 [doi]
AB  - Along with the increasing cancer incidence, developing suitable drug delivery 
      systems (DDSs) is becoming urgent to control drug release and further enhance 
      therapeutic efficiency. Herein, a Fe-Zn bimetallic MOF-derived ferromagnetic 
      nanomaterial was synthesized by a one-step method. The successful preparation of 
      ferromagnetic Fe-ZIF-8 was verified by scanning electron microscopy, powder X-ray 
      diffraction, Brunauer-Emmett-Teller, X-ray photoelectron spectroscopy, and 
      physical property measurement system characterizations. Furthermore, the release 
      behaviors of 5-FU from the ferromagnetic carrier were investigated in a 
      simulative cancer microenvironment of PBS buffer solution (PBS = 
      phosphate-buffered saline, pH = 5.8) and NaHS solution. The vehicle in PBS 
      solution of pH = 5.8 and NaHS solution of 500 muM can rapidly release 5-FU with 
      the cumulative release percentages of 68 and 36%, respectively, within two 
      hundred minutes. The release mechanism in the weak acid environment can be mainly 
      attributed to the decomposition of the Fe-ZIF-8. However, the strong interaction 
      between Zn and Fe atoms in Fe-ZIF-8 and the S atom in H(2)S plays an important 
      role in the release process in the simulated H(2)S cancer microenvironment. The 
      investigation of release kinetic models indicates that the 5-FU release in the 
      PBS solutions and NaHS solution of 500 muM can be accurately fitted by a 
      second-degree polynomial model and first-order model, respectively. In addition, 
      the decomposition products, zinc, iron, and 2-MeIM, are endogenous and show low 
      toxicity values [LD(50) (Zn) = 0.35 g.kg(-1), LD(50) (Fe) = 30 g.kg(-1), and 
      LD(50) (2-MeIM) = 1.4 g.kg(-1)]. Therefore, the low-toxicity, pH and H(2)S 
      dual-stimuli-responsive, and ferromagnetic nature make the obtained Fe-ZIF-8 an 
      ideal candidate in the field of bioactive molecule delivery.
FAU - Zhao, Huifang
AU  - Zhao H
AD  - State Key Laboratory of Organic-Inorganic Composites, Beijing University of 
      Chemical Technology, North Third Ring Road 15, Chaoyang District, Beijing 100029, 
      P. R. China.
FAU - Zhao, Yingjie
AU  - Zhao Y
AD  - State Key Laboratory of Organic-Inorganic Composites, Beijing University of 
      Chemical Technology, North Third Ring Road 15, Chaoyang District, Beijing 100029, 
      P. R. China.
FAU - Liu, Dahuan
AU  - Liu D
AUID- ORCID: 0000-0003-1005-3168
AD  - State Key Laboratory of Organic-Inorganic Composites, Beijing University of 
      Chemical Technology, North Third Ring Road 15, Chaoyang District, Beijing 100029, 
      P. R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210824
PL  - United States
TA  - ACS Appl Bio Mater
JT  - ACS applied bio materials
JID - 101729147
RN  - 0 (Metal-Organic Frameworks)
RN  - U3P01618RT (Fluorouracil)
SB  - IM
MH  - Drug Liberation
MH  - Fluorouracil/pharmacology
MH  - Hydrogen-Ion Concentration
MH  - Magnetic Phenomena
MH  - *Metal-Organic Frameworks/chemistry
OTO - NOTNLM
OT  - Fe-Zn bimetallic MOF
OT  - ferromagnetic nanomaterial
OT  - low toxicity
OT  - pH and H2S dual-stimuli-responsive
OT  - rapid release
OT  - target release
EDAT- 2022/01/11 06:00
MHDA- 2022/04/09 06:00
CRDT- 2022/01/10 17:13
PHST- 2022/01/10 17:13 [entrez]
PHST- 2022/01/11 06:00 [pubmed]
PHST- 2022/04/09 06:00 [medline]
AID - 10.1021/acsabm.1c00710 [doi]
PST - ppublish
SO  - ACS Appl Bio Mater. 2021 Sep 20;4(9):7103-7110. doi: 10.1021/acsabm.1c00710. Epub 
      2021 Aug 24.