PMID- 35008231
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220114
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 14
IP  - 1
DP  - 2021 Dec 23
TI  - Validation of Pre-/Post-TACE-Predict Models among Patients with Hepatocellular 
      Carcinoma Receiving Transarterial Chemoembolization.
LID - 10.3390/cancers14010067 [doi]
LID - 67
AB  - This study attempted to validate the prognostic performance of the proposed Pre- 
      and Post-TACE (transarterial chemoembolization)-Predict models, in comparison 
      with other models for prognostication. One-hundred-and-eighty-seven patients with 
      HCC who underwent TACE were recruited. Regarding overall survival (OS), the 
      predictive performance of the Pre-TACE-Predict model (one-year integrated area 
      under the curve (iAUC) 0.685 (95% confidence interval (CI) 0.593-0.772)) was 
      better than that of the Post-TACE-Predict model (iAUC 0.659 (95% CI 
      0.580-0.742)). However, there was no significant statistical difference between 
      two models at any time point. For comparison between models using pre-treatment 
      factors, the modified hepatoma arterial embolization prognostic (mHAP)-II model 
      demonstrated significantly better predictive performance at one year (iAUC 0.767 
      (95% CI 0.683-0.847)) compared with Pre-TACE-Predict. For comparison between 
      models using first TACE response, the SNACOR model was significantly more 
      predictive at one year (iAUC 0.778 (95% CI 0.687-0.866) vs. 0.659 (95% CI 
      0.580-0.742), respectively) and three years (iAUC 0.707 (95% CI 0.646-0.770) vs. 
      0.624 (95% CI 0.564-0.688), respectively) than the Post-TACE-Predict model. 
      mHAP-II and SNACOR may be preferred over the Pre- and Post-TACE-Predict models, 
      respectively, considering their similar or better performance and the ease of 
      application.
FAU - Kim, David Sooik
AU  - Kim DS
AD  - Department of Internal Medicine, Yonsei University College of Medicine, Seoul 
      03722, Korea.
FAU - Kim, Beom Kyung
AU  - Kim BK
AD  - Department of Internal Medicine, Yonsei University College of Medicine, Seoul 
      03722, Korea.
AD  - Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 
      03722, Korea.
AD  - Yonsei Liver Center, Severance Hospital, Yonsei University Health System, Seoul 
      03722, Korea.
FAU - Lee, Jae Seung
AU  - Lee JS
AUID- ORCID: 0000-0002-2371-0967
AD  - Department of Internal Medicine, Yonsei University College of Medicine, Seoul 
      03722, Korea.
AD  - Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 
      03722, Korea.
AD  - Yonsei Liver Center, Severance Hospital, Yonsei University Health System, Seoul 
      03722, Korea.
FAU - Lee, Hye Won
AU  - Lee HW
AUID- ORCID: 0000-0002-3552-3560
AD  - Department of Internal Medicine, Yonsei University College of Medicine, Seoul 
      03722, Korea.
AD  - Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 
      03722, Korea.
AD  - Yonsei Liver Center, Severance Hospital, Yonsei University Health System, Seoul 
      03722, Korea.
FAU - Park, Jun Yong
AU  - Park JY
AUID- ORCID: 0000-0001-6324-2224
AD  - Department of Internal Medicine, Yonsei University College of Medicine, Seoul 
      03722, Korea.
AD  - Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 
      03722, Korea.
AD  - Yonsei Liver Center, Severance Hospital, Yonsei University Health System, Seoul 
      03722, Korea.
FAU - Kim, Do Young
AU  - Kim DY
AUID- ORCID: 0000-0002-8327-3439
AD  - Department of Internal Medicine, Yonsei University College of Medicine, Seoul 
      03722, Korea.
AD  - Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 
      03722, Korea.
AD  - Yonsei Liver Center, Severance Hospital, Yonsei University Health System, Seoul 
      03722, Korea.
FAU - Ahn, Sang Hoon
AU  - Ahn SH
AD  - Department of Internal Medicine, Yonsei University College of Medicine, Seoul 
      03722, Korea.
AD  - Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 
      03722, Korea.
AD  - Yonsei Liver Center, Severance Hospital, Yonsei University Health System, Seoul 
      03722, Korea.
FAU - Kim, Seung Up
AU  - Kim SU
AUID- ORCID: 0000-0002-9658-8050
AD  - Department of Internal Medicine, Yonsei University College of Medicine, Seoul 
      03722, Korea.
AD  - Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 
      03722, Korea.
AD  - Yonsei Liver Center, Severance Hospital, Yonsei University Health System, Seoul 
      03722, Korea.
LA  - eng
GR  - 2019R1A2C4070136/National Research Foundation of Korea/
PT  - Journal Article
DEP - 20211223
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC8750487
OTO - NOTNLM
OT  - hepatocellular carcinoma
OT  - prediction
OT  - prognosis
OT  - risk
OT  - transarterial chemoembolization
COIS- The authors declare no conflict of interest.
EDAT- 2022/01/12 06:00
MHDA- 2022/01/12 06:01
PMCR- 2021/12/23
CRDT- 2022/01/11 01:01
PHST- 2021/11/23 00:00 [received]
PHST- 2021/12/17 00:00 [revised]
PHST- 2021/12/20 00:00 [accepted]
PHST- 2022/01/11 01:01 [entrez]
PHST- 2022/01/12 06:00 [pubmed]
PHST- 2022/01/12 06:01 [medline]
PHST- 2021/12/23 00:00 [pmc-release]
AID - cancers14010067 [pii]
AID - cancers-14-00067 [pii]
AID - 10.3390/cancers14010067 [doi]
PST - epublish
SO  - Cancers (Basel). 2021 Dec 23;14(1):67. doi: 10.3390/cancers14010067.