PMID- 35008291
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220114
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 14
IP  - 1
DP  - 2021 Dec 28
TI  - Prediction of Chemotoxicity, Unplanned Hospitalizations and Early Death in Older 
      Patients with Colorectal Cancer Treated with Chemotherapy.
LID - 10.3390/cancers14010127 [doi]
LID - 127
AB  - PURPOSE: To identify risk factors for toxicity, unplanned hospitalization (UH) 
      and early death (ED) in older patients with colorectal carcinoma (CRC) initiating 
      chemotherapy. METHODS: 215 patients over 70 years were prospectively included. 
      Geriatric assessment was performed before treatment, and tumor and treatment 
      variables were collected. The association between these factors and grade 3-5 
      toxicity, UH and ED (<6 months) was examined by using multivariable logistic 
      regression. Score points were assigned to each risk factor. RESULTS: During the 
      first 6 months of treatment, 33% of patients developed grade 3-5 toxicity, 31% 
      had UH and 23% died. Risk factors were, for toxicity, instrumental activities of 
      daily living, creatinine clearance, weight loss and MAX2 index; for UH, Charlson 
      Comorbidity Score, creatinine clearance, weight loss, serum albumin, and 
      metastatic disease; and for ED, basic activities in daily living, weight loss, 
      metastatic disease, and hemoglobin levels. Predictive scores were built with 
      these variables. The areas under receiver operation characteristic (ROC) curves 
      for toxicity, UH and ED were 0.70 (95% CI: 0.64-0.766), 0.726 (95% IC: 
      0.661-0.799) and 0.74 (95% IC: 0.678-0.809), respectively. CONCLUSION: Simple 
      scores based on geriatric, tumor and laboratory characteristics predict severe 
      toxicity, UH and ED, and may help in treatment planning.
FAU - Feliu, Jaime
AU  - Feliu J
AUID- ORCID: 0000-0003-4867-1420
AD  - Oncology Department, La Paz University Hospital, IDIPAZ, CIBERONC, UAM-AMGEN 
      Cathedra, 28046 Madrid, Spain.
FAU - Espinosa, Enrique
AU  - Espinosa E
AD  - Oncology Department, La Paz University Hospital, IDIPAZ, CIBERONC, UAM-AMGEN 
      Cathedra, 28046 Madrid, Spain.
FAU - Basterretxea, Laura
AU  - Basterretxea L
AD  - Oncology Department, Donostia University Hospital, 20014 Donostia, Spain.
FAU - Paredero, Irene
AU  - Paredero I
AUID- ORCID: 0000-0003-3618-8685
AD  - Oncology Department, Doctor Peset University Hospital, 46017 Valencia, Spain.
FAU - Llabres, Elisenda
AU  - Llabres E
AD  - Oncology Department, Insular University Hospital of Gran Canarias, 35016 Las 
      Palmas, Spain.
FAU - Jimenez-Munarriz, Beatriz
AU  - Jimenez-Munarriz B
AD  - Oncology Department, Centro Integral Oncologico Clara Campal, 28050 Madrid, 
      Spain.
FAU - Antonio-Rebollo, Maite
AU  - Antonio-Rebollo M
AD  - Oncohematogeriatrics Unit, Institut Catala d'Oncologia, IDIBELL Hospitalet, 08908 
      Barcelona, Spain.
FAU - Losada, Beatriz
AU  - Losada B
AUID- ORCID: 0000-0001-9283-4333
AD  - Oncology Department, University Hospital of Fuenlabrada, 28942 Madrid, Spain.
FAU - Pinto, Alvaro
AU  - Pinto A
AD  - Oncology Department, La Paz University Hospital, IDIPAZ, CIBERONC, UAM-AMGEN 
      Cathedra, 28046 Madrid, Spain.
FAU - Custodio, Ana Belen
AU  - Custodio AB
AD  - Oncology Department, La Paz University Hospital, IDIPAZ, CIBERONC, UAM-AMGEN 
      Cathedra, 28046 Madrid, Spain.
FAU - Del Mar Munoz, Maria
AU  - Del Mar Munoz M
AD  - Oncology Department, Hospital Virgen de la Luz, 16002 Cuenca, Spain.
FAU - Gomez-Mediavilla, Jenifer
AU  - Gomez-Mediavilla J
AD  - Oncology Department, Donostia University Hospital, 20014 Donostia, Spain.
FAU - Torregrosa, Maria-Dolores
AU  - Torregrosa MD
AD  - Oncology Department, Doctor Peset University Hospital, 46017 Valencia, Spain.
FAU - Soler, Gema
AU  - Soler G
AD  - Oncohematogeriatrics Unit, Institut Catala d'Oncologia, IDIBELL Hospitalet, 08908 
      Barcelona, Spain.
FAU - Cruz, Patricia
AU  - Cruz P
AD  - Oncology Department, La Paz University Hospital, IDIPAZ, CIBERONC, UAM-AMGEN 
      Cathedra, 28046 Madrid, Spain.
FAU - Higuera, Oliver
AU  - Higuera O
AD  - Oncology Department, La Paz University Hospital, IDIPAZ, CIBERONC, UAM-AMGEN 
      Cathedra, 28046 Madrid, Spain.
FAU - Molina-Garrido, Maria-Jose
AU  - Molina-Garrido MJ
AD  - Oncology Department, Hospital Virgen de la Luz, 16002 Cuenca, Spain.
LA  - eng
PT  - Journal Article
DEP - 20211228
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC8749992
OTO - NOTNLM
OT  - cancer
OT  - chemo-toxicities
OT  - early death
OT  - frailty
OT  - geriatric assessment
OT  - older
OT  - prognostic
OT  - unplanned hospitalizations
COIS- The authors declare no conflict of interest.
EDAT- 2022/01/12 06:00
MHDA- 2022/01/12 06:01
PMCR- 2021/12/28
CRDT- 2022/01/11 01:01
PHST- 2021/12/12 00:00 [received]
PHST- 2021/12/15 00:00 [revised]
PHST- 2021/12/23 00:00 [accepted]
PHST- 2022/01/11 01:01 [entrez]
PHST- 2022/01/12 06:00 [pubmed]
PHST- 2022/01/12 06:01 [medline]
PHST- 2021/12/28 00:00 [pmc-release]
AID - cancers14010127 [pii]
AID - cancers-14-00127 [pii]
AID - 10.3390/cancers14010127 [doi]
PST - epublish
SO  - Cancers (Basel). 2021 Dec 28;14(1):127. doi: 10.3390/cancers14010127.