PMID- 35008447
OWN - NLM
STAT- MEDLINE
DCOM- 20220131
LR  - 20220131
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 23
IP  - 1
DP  - 2021 Dec 21
TI  - Meta-Analysis and Bioinformatics Detection of Susceptibility Genes in Diabetic 
      Nephropathy.
LID - 10.3390/ijms23010020 [doi]
LID - 20
AB  - The latest meta-analysis of genome-wide linkage studies (GWLS) identified nine 
      cytogenetic locations suggestive of a linkage with diabetic nephropathy (DN) due 
      to type 1 diabetes mellitus (T1DM) and seven locations due to type 2 diabetes 
      mellitus (T2DM). In order to gain biological insight about the functional role of 
      the genes located in these regions and to prioritize the most significant genetic 
      loci for further research, we conducted a gene ontology analysis with an over 
      representation test for the functional annotation of the protein coding genes. 
      Protein analysis through evolutionary relationships (PANTHER) version 16.0 
      software and Cytoscape with the relevant plugins were used for the gene ontology 
      analysis, and the overrepresentation test and STRING database were used for the 
      construction of the protein network. The findings of the over-representation test 
      highlight the contribution of immune related molecules like immunoglobulins, 
      cytokines, and chemokines with regard to the most overrepresented protein 
      classes, whereas the most enriched signaling pathways include the VEGF signaling 
      pathway, the Cadherin pathway, the Wnt pathway, the angiogenesis pathway, the p38 
      MAPK pathway, and the EGF receptor signaling pathway. The common section of T1DM 
      and T2DM results include the significant over representation of immune related 
      molecules, and the Cadherin and Wnt signaling pathways that could constitute 
      potential therapeutic targets for the treatment of DN, irrespective of the type 
      of diabetes.
FAU - Tziastoudi, Maria
AU  - Tziastoudi M
AUID- ORCID: 0000-0002-7206-2716
AD  - Department of Nephrology, Faculty of Medicine, School of Health Sciences, 
      University of Thessaly, 41500 Larisa, Greece.
FAU - Cholevas, Christos
AU  - Cholevas C
AUID- ORCID: 0000-0002-1517-8691
AD  - First Department of Ophthalmology, Faculty of Health Sciences, Aristotle 
      University of Thessaloniki School of Medicine, AHEPA Hospital, 54636 
      Thessaloniki, Greece.
FAU - Theoharides, Theoharis C
AU  - Theoharides TC
AUID- ORCID: 0000-0002-1598-460X
AD  - Department of Immunology, Tufts University School of Medicine, Boston, MA 02111, 
      USA.
FAU - Stefanidis, Ioannis
AU  - Stefanidis I
AD  - Department of Nephrology, Faculty of Medicine, School of Health Sciences, 
      University of Thessaly, 41500 Larisa, Greece.
LA  - eng
GR  - MIS-5033021/State Scholarships Foundation/
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20211221
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
SB  - IM
MH  - Computational Biology/*methods
MH  - Diabetes Mellitus, Type 1/*complications/genetics
MH  - Diabetes Mellitus, Type 2/*complications/genetics
MH  - Diabetic Nephropathies/etiology/*genetics
MH  - Gene Expression Regulation
MH  - *Gene Regulatory Networks
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Molecular Sequence Annotation
PMC - PMC8744540
OTO - NOTNLM
OT  - diabetic nephropathy
OT  - gene ontology
OT  - genes
OT  - meta-analysis
OT  - protein network
OT  - signaling pathway
COIS- The authors declare no conflict of interest.
EDAT- 2022/01/12 06:00
MHDA- 2022/02/01 06:00
PMCR- 2021/12/21
CRDT- 2022/01/11 01:02
PHST- 2021/10/14 00:00 [received]
PHST- 2021/12/15 00:00 [revised]
PHST- 2021/12/18 00:00 [accepted]
PHST- 2022/01/11 01:02 [entrez]
PHST- 2022/01/12 06:00 [pubmed]
PHST- 2022/02/01 06:00 [medline]
PHST- 2021/12/21 00:00 [pmc-release]
AID - ijms23010020 [pii]
AID - ijms-23-00020 [pii]
AID - 10.3390/ijms23010020 [doi]
PST - epublish
SO  - Int J Mol Sci. 2021 Dec 21;23(1):20. doi: 10.3390/ijms23010020.