PMID- 35010453
OWN - NLM
STAT- MEDLINE
DCOM- 20220124
LR  - 20220124
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 19
IP  - 1
DP  - 2021 Dec 24
TI  - Gender Difference in the Associations among Heavy Metals with Red Blood Cell 
      Hemogram.
LID - 10.3390/ijerph19010189 [doi]
LID - 189
AB  - This study aimed to investigate gender differences in the association between 
      heavy metals and hemograms including hemoglobin (Hgb), mean corpuscular volume 
      (MCV) and mean corpuscular hemoglobin concentration (MCHC). A health survey of 
      2447 participants was conducted in southern Taiwan between June 2016 and 
      September 2018. Seven heavy metals were measured: blood lead (Pb), urine nickel 
      (Ni), urine chromium (Cr), urine manganese, urine arsenic (As), urine copper and 
      urine cadmium (Cd). The results show that in females, Pb and Ni were 
      significantly negatively associated with Hgb. In addition, As and Cd were 
      significantly positively, and Pb and Ni were significantly negatively, associated 
      with MCV, in males and females, respectively. The interactions between gender and 
      Ni and gender and Cd in MCV were statistically significant. Further, Pb, in 
      males, and Pb, Ni and Cr, in females, were significantly negatively associated 
      with MCHC. In conclusion, in females, associations of red blood cell (RBC) 
      hemograms with heavy metals such as Pb and Ni were found. In males, heavy metals 
      such as Pb, As and Cd were found to associate with RBC hemograms. Further 
      research is warranted to discuss the mechanism behind these associations.
FAU - Huang, Chao-Hsin
AU  - Huang CH
AD  - Department of Post Baccalaureate Medicine, Kaohsiung Medical University, 
      Kaohsiung 807, Taiwan.
FAU - Wang, Chih-Wen
AU  - Wang CW
AD  - Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung 
      Medical University, Kaohsiung 812, Taiwan.
AD  - Department of Internal Medicine, Division of Hepatobiliary, Kaohsiung Medical 
      University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
FAU - Chen, Huang-Chi
AU  - Chen HC
AD  - Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung 
      Medical University, Kaohsiung 812, Taiwan.
AD  - Department of Internal Medicine, Division of Pulmonary and Critical Care 
      Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 
      Kaohsiung 807, Taiwan.
FAU - Tu, Hung-Pin
AU  - Tu HP
AUID- ORCID: 0000-0003-1044-2673
AD  - Department of Public Health and Environmental Medicine, School of Medicine, 
      College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
FAU - Chen, Szu-Chia
AU  - Chen SC
AUID- ORCID: 0000-0002-1610-4184
AD  - Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung 
      Medical University, Kaohsiung 812, Taiwan.
AD  - Department of Internal Medicine, Division of Nephrology, Kaohsiung Medical 
      University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
AD  - Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 
      807, Taiwan.
AD  - Research Center for Environmental Medicine, Kaohsiung Medical University, 
      Kaohsiung 807, Taiwan.
FAU - Hung, Chih-Hsing
AU  - Hung CH
AUID- ORCID: 0000-0002-2026-5108
AD  - Research Center for Environmental Medicine, Kaohsiung Medical University, 
      Kaohsiung 807, Taiwan.
AD  - Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung 
      Medical University, Kaohsiung 807, Taiwan.
AD  - Department of Pediatrics, Kaohsiung Municipal Siaogang Hospital, Kaohsiung 
      Medical University, Kaohsiung 812, Taiwan.
FAU - Kuo, Chao-Hung
AU  - Kuo CH
AD  - Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung 
      Medical University, Kaohsiung 812, Taiwan.
AD  - Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 
      807, Taiwan.
AD  - Department of Internal Medicine, Division of Gastroenterology, Kaohsiung Medical 
      University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20211224
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (Metals, Heavy)
RN  - 00BH33GNGH (Cadmium)
RN  - 0R0008Q3JB (Chromium)
SB  - IM
MH  - Cadmium/analysis
MH  - Chromium/analysis
MH  - Environmental Monitoring
MH  - Erythrocytes/chemistry
MH  - Female
MH  - Humans
MH  - Male
MH  - *Metals, Heavy/analysis
MH  - Sex Factors
PMC - PMC8750598
OTO - NOTNLM
OT  - heavy metal
OT  - hemoglobin
OT  - mean corpuscular hemoglobin concentration
OT  - mean corpuscular volume
COIS- The authors declare no conflict of interest.
EDAT- 2022/01/12 06:00
MHDA- 2022/01/27 06:00
PMCR- 2021/12/24
CRDT- 2022/01/11 01:10
PHST- 2021/11/15 00:00 [received]
PHST- 2021/12/22 00:00 [revised]
PHST- 2021/12/23 00:00 [accepted]
PHST- 2022/01/11 01:10 [entrez]
PHST- 2022/01/12 06:00 [pubmed]
PHST- 2022/01/27 06:00 [medline]
PHST- 2021/12/24 00:00 [pmc-release]
AID - ijerph19010189 [pii]
AID - ijerph-19-00189 [pii]
AID - 10.3390/ijerph19010189 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2021 Dec 24;19(1):189. doi: 
      10.3390/ijerph19010189.