PMID- 3501078
OWN - NLM
STAT- MEDLINE
DCOM- 19880208
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 81
IP  - 1-2
DP  - 1987 Oct 16
TI  - Alterations of the muscarinic cholinergic (mACh) receptors in the striatum of the 
      MPTP-induced parkinsonian model in mice: in vitro quantitative autoradiographical 
      analysis.
PG  - 105-10
AB  - The alteration of muscarinic cholinergic (mACh) receptors in the striatum of mice 
      after administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was 
      examined using a [3H]quinuclidinyl benzilate [( 3H]QNB) in vitro labeling 
      macro-autoradiographic technique and mACh receptor concentration was 
      quantitatively analyzed using a computer analysis system. Two weeks after 
      cessation of MPTP administration, the striatal mACh receptors were significantly 
      increased. In the subchronic phase, at 6 weeks, the striatal mACh receptors were 
      significantly decreased but recovered to the normal level by the treatment with 
      L-dihydroxyphenylalanine (L-DOPA) for two weeks before sacrifice. These findings 
      indicated that the striatal mACh receptors are strongly regulated by the 
      nigrostriatal dopaminergic function.
FAU - Mizukawa, K
AU  - Mizukawa K
AD  - Department of Anatomy, Okayama University Medical School, Japan.
FAU - Ogawa, N
AU  - Ogawa N
FAU - Sora, Y H
AU  - Sora YH
FAU - Sora, I
AU  - Sora I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Pyridines)
RN  - 0 (Receptors, Muscarinic)
RN  - 10028-17-8 (Tritium)
RN  - 6581-06-2 (Quinuclidinyl Benzilate)
RN  - 9P21XSP91P (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
MH  - Animals
MH  - Autoradiography
MH  - Corpus Striatum/drug effects/*metabolism/pathology
MH  - Disease Models, Animal
MH  - Dopamine/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Parkinson Disease/*metabolism
MH  - Pyridines/*toxicity
MH  - Quinuclidinyl Benzilate/metabolism
MH  - Receptors, Muscarinic/drug effects/*metabolism
MH  - Tritium
EDAT- 1987/10/16 00:00
MHDA- 1987/10/16 00:01
CRDT- 1987/10/16 00:00
PHST- 1987/10/16 00:00 [pubmed]
PHST- 1987/10/16 00:01 [medline]
PHST- 1987/10/16 00:00 [entrez]
AID - 0304-3940(87)90348-X [pii]
AID - 10.1016/0304-3940(87)90348-x [doi]
PST - ppublish
SO  - Neurosci Lett. 1987 Oct 16;81(1-2):105-10. doi: 10.1016/0304-3940(87)90348-x.