PMID- 35010979
OWN - NLM
STAT- MEDLINE
DCOM- 20220131
LR  - 20220131
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 1
DP  - 2021 Dec 27
TI  - Magnesium Lithospermate B Attenuates High-Fat Diet-Induced Muscle Atrophy in 
      C57BL/6J Mice.
LID - 10.3390/nu14010104 [doi]
LID - 104
AB  - Magnesium lithospermate B (MLB) is a primary hydrophilic component of Danshen, 
      the dried root of Salvia miltiorrhiza used in traditional medicine, and its 
      beneficial effects on obesity-associated metabolic abnormalities were reported in 
      our previous study. The present study investigated the anti-muscle atrophy 
      potential of MLB in mice with high-fat diet (HFD)-induced obesity. In addition to 
      metabolic abnormalities, the HFD mice had a net loss of skeletal muscle weight 
      and muscle fibers and high levels of muscle-specific ubiquitin E3 ligases, namely 
      the muscle atrophy F-box (MAFbx) and muscle RING finger protein 1 (MuRF-1). MLB 
      supplementation alleviated those health concerns. Parallel changes were revealed 
      in high circulating tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), 
      skeletal TNF receptor I (TNFRI), nuclear factor-kappa light chain enhancer of 
      activated B cells (NF-kappaB), p65 phosphorylation, and Forkhead box protein O1 
      (FoxO1) as well as low skeletal phosphoinositide 3-kinase (PI3K) and protein 
      kinase B (Akt) phosphorylation. The study revealed that MLB prevented 
      obesity-associated skeletal muscle atrophy, likely through the inhibition of 
      MAFbx/MuRF-1-mediated muscular degradation. The activation of the PI3K-Akt-FoxO1 
      pathway and inhibition of the TNF-alpha/TNFRI/NF-kappaB pathway were assumed to be 
      beneficial effects of MLB.
FAU - Cheng, Tsun-Li
AU  - Cheng TL
AD  - Veterinary Medical Teaching Hospital, National Chung Hsing University, Taichung 
      402, Taiwan.
FAU - Lin, Zi-Yun
AU  - Lin ZY
AD  - Department of Veterinary Medicine, National Chung Hsing University, Taichung 402, 
      Taiwan.
FAU - Liao, Keng-Ying
AU  - Liao KY
AD  - Department of Veterinary Medicine, National Chung Hsing University, Taichung 402, 
      Taiwan.
FAU - Huang, Wei-Chi
AU  - Huang WC
AD  - Department of Veterinary Medicine, National Chung Hsing University, Taichung 402, 
      Taiwan.
FAU - Jhuo, Cian-Fen
AU  - Jhuo CF
AUID- ORCID: 0000-0003-1123-0015
AD  - Graduate Institute of Biotechnology, National Chung Hsing University, Taichung 
      402, Taiwan.
FAU - Pan, Pin-Ho
AU  - Pan PH
AD  - Department of Veterinary Medicine, National Chung Hsing University, Taichung 402, 
      Taiwan.
AD  - Department of Pediatrics, Tungs' Taichung Metro Harbor Hospital, Taichung 435, 
      Taiwan.
FAU - Chen, Chun-Jung
AU  - Chen CJ
AD  - Department of Medical Research, Taichung Veterans General Hospital, Taichung 407, 
      Taiwan.
FAU - Kuan, Yu-Hsiang
AU  - Kuan YH
AUID- ORCID: 0000-0002-8991-6394
AD  - Department of Pharmacology, School of Medicine, Chung Shan Medical University, 
      Taichung 402, Taiwan.
FAU - Chen, Wen-Ying
AU  - Chen WY
AUID- ORCID: 0000-0002-5105-5285
AD  - Veterinary Medical Teaching Hospital, National Chung Hsing University, Taichung 
      402, Taiwan.
AD  - Department of Veterinary Medicine, National Chung Hsing University, Taichung 402, 
      Taiwan.
LA  - eng
GR  - (TCVGH-NCHU1107607/National Chung Hsing University/
PT  - Journal Article
DEP - 20211227
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Cytokines)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Free Radical Scavengers)
RN  - 122021-74-3 (lithospermate B)
SB  - IM
MH  - Animals
MH  - Chemical and Drug Induced Liver Injury/drug therapy/prevention & control
MH  - Cytokines/genetics/metabolism
MH  - Diet, High-Fat/*adverse effects
MH  - Dietary Supplements
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Dyslipidemias/drug therapy
MH  - Free Radical Scavengers/pharmacology
MH  - Gene Expression Regulation/drug effects
MH  - Insulin Resistance
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Muscular Atrophy/*chemically induced
MH  - Random Allocation
PMC - PMC8746630
OTO - NOTNLM
OT  - inflammation
OT  - insulin resistance
OT  - magnesium lithospermate B
OT  - muscle atrophy
OT  - obesity
COIS- The authors declare that they have no conflict of interest.
EDAT- 2022/01/12 06:00
MHDA- 2022/02/01 06:00
PMCR- 2021/12/27
CRDT- 2022/01/11 01:12
PHST- 2021/11/22 00:00 [received]
PHST- 2021/12/23 00:00 [revised]
PHST- 2021/12/23 00:00 [accepted]
PHST- 2022/01/11 01:12 [entrez]
PHST- 2022/01/12 06:00 [pubmed]
PHST- 2022/02/01 06:00 [medline]
PHST- 2021/12/27 00:00 [pmc-release]
AID - nu14010104 [pii]
AID - nutrients-14-00104 [pii]
AID - 10.3390/nu14010104 [doi]
PST - epublish
SO  - Nutrients. 2021 Dec 27;14(1):104. doi: 10.3390/nu14010104.