PMID- 35011030
OWN - NLM
STAT- MEDLINE
DCOM- 20220121
LR  - 20240226
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 1
DP  - 2021 Dec 29
TI  - An Avocado Extract Enriched in Mannoheptulose Prevents the Negative Effects of a 
      High-Fat Diet in Mice.
LID - 10.3390/nu14010155 [doi]
LID - 155
AB  - Beginning at 16 weeks of age and continuing for 44 weeks, male C57BL/6J were fed 
      either a control (CON) diet; a high-fat (HF) diet (60% unsaturated); or the HF 
      diet containing an extract of unripe avocados (AvX) enriched in the 7-carbon 
      sugar mannoheptulose (MH), designed to act as a glycolytic inhibitor (HF + MH). 
      Compared to the CON diet, mice on the HF diet exhibited higher body weights; body 
      fat; blood lipids; and leptin with reduced adiponectin levels, insulin 
      sensitivity, VO2max, and falls from a rotarod. Mice on the HF + MH diet were 
      completely protected against these changes in the absence of significant diet 
      effects on food intake. Compared to the CON diet, oxidative stress was also 
      increased by the HF diet indicated by higher levels of total reactive oxygen 
      species, superoxide, and peroxynitrite measured in liver samples by electron 
      paramagnetic resonance spectroscopy, whereas the HF + MH diet attenuated these 
      changes. Compared to the CON, the HF diet increased signaling in the mechanistic 
      target of the rapamycin (mTOR) pathway, and the addition of the MH-enriched AvX 
      to this diet attenuated these changes. Beyond generating further interest in the 
      health benefits of avocados, these results draw further new attention to the 
      effects of this rare sugar, MH, as a botanical intervention for preventing 
      obesity.
FAU - Pistell, Paul J
AU  - Pistell PJ
AD  - Department of Psychology, Towson University, 8000 York Road, Towson, MD 21252, 
      USA.
FAU - Utsuki, Tadanobu
AU  - Utsuki T
AD  - Institute for Drug Discovery, Purdue University, 720 Clinic Drive, West 
      Lafayette, IN 47907, USA.
FAU - Francis, Joseph
AU  - Francis J
AD  - Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State 
      University, Skip Bertman Drive, Baton Rouge, LA 70803, USA.
FAU - Ebenezer, Philip J
AU  - Ebenezer PJ
AD  - Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State 
      University, Skip Bertman Drive, Baton Rouge, LA 70803, USA.
FAU - Terrebonne, Jennifer
AU  - Terrebonne J
AD  - Pennington Biomedical Research Center, Louisiana State University, 5600 Perkins 
      Road, Baton Rouge, LA 70808, USA.
FAU - Roth, George S
AU  - Roth GS
AD  - GeroScience, Inc., 19895 Southern Hills, Baton Rouge, LA 70809, USA.
FAU - Ingram, Donald K
AU  - Ingram DK
AD  - Pennington Biomedical Research Center, Louisiana State University, 5600 Perkins 
      Road, Baton Rouge, LA 70808, USA.
AD  - GeroScience, Inc., 19895 Southern Hills, Baton Rouge, LA 70809, USA.
LA  - eng
GR  - Grant #1-P50 AT002776-01/AT/NCCIH NIH HHS/United States
PT  - Journal Article
DEP - 20211229
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Heptoses)
RN  - 0 (Plant Extracts)
RN  - 0 (mannoheptose)
RN  - EC 2.7.1.1 (mTOR protein, mouse)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Diet, High-Fat/*adverse effects
MH  - *Dietary Supplements
MH  - Heptoses/*administration & dosage/analysis/pharmacology
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Obesity/*etiology/*prevention & control
MH  - Oxidative Stress/drug effects
MH  - Persea/*chemistry
MH  - *Phytotherapy
MH  - Plant Extracts/*administration & dosage/analysis/pharmacology
MH  - Signal Transduction/drug effects
MH  - TOR Serine-Threonine Kinases/metabolism
MH  - Mice
PMC - PMC8746741
OTO - NOTNLM
OT  - adipokines
OT  - glycolysis
OT  - insulin
OT  - mTOR
OT  - metabolism
OT  - obesity
OT  - oxidative stress
OT  - rare sugar
COIS- Ingram and Roth declare financial interest in the avocado extract as the Chief 
      Scientific Officer and Chief Executive Officer, respectively, of GeroScience, 
      Inc., which owns patents to the product. No other author has a conflict of 
      interest.
EDAT- 2022/01/12 06:00
MHDA- 2022/01/22 06:00
PMCR- 2021/12/29
CRDT- 2022/01/11 01:13
PHST- 2021/11/17 00:00 [received]
PHST- 2021/12/22 00:00 [revised]
PHST- 2021/12/26 00:00 [accepted]
PHST- 2022/01/11 01:13 [entrez]
PHST- 2022/01/12 06:00 [pubmed]
PHST- 2022/01/22 06:00 [medline]
PHST- 2021/12/29 00:00 [pmc-release]
AID - nu14010155 [pii]
AID - nutrients-14-00155 [pii]
AID - 10.3390/nu14010155 [doi]
PST - epublish
SO  - Nutrients. 2021 Dec 29;14(1):155. doi: 10.3390/nu14010155.