PMID- 35011819
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220114
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Dec 24
TI  - Review: Serum Biomarkers of Lung Fibrosis in Interstitial Pneumonia with 
      Autoimmune Features-What Do We Already Know?
LID - 10.3390/jcm11010079 [doi]
LID - 79
AB  - Interstitial pneumonia with autoimmune features (IPAF) belongs to a group of 
      diseases called interstitial lung diseases (ILDs), which are disorders of a 
      varied prognosis and course. Finding sufficiently specific and sensitive 
      biomarkers would enable the progression to be predicted, the natural history to 
      be monitored and patients to be stratified according to their treatment. To 
      assess the significance of pulmonary fibrosis biomarkers studied thus far, we 
      searched the PubMed, Medline and Cochrane Library databases for papers published 
      between January 2015 and June 2021. We focused on circulating biomarkers. A 
      primary review of the databases identified 38 articles of potential interest. 
      Overall, seven articles fulfilled the inclusion criteria. This review aims to 
      assess the diagnostic and prognostic value of molecules such as KL-6, SP-A, SP-D, 
      circulating fibrocytes, CCL2, CXCL13, CXCL9, CXCL10 and CXCL11. All of these 
      biomarkers have previously been studied in idiopathic pulmonary fibrosis (IPF) 
      and connective tissue disease-associated interstitial lung disease (CTD-ILD). 
      IPAF is a disorder of a heterogeneous nature. It explains the lack of coherent 
      observations in terms of correlations with functional parameters. There is still 
      no meta-analysis of pulmonary fibrosis biomarkers in IPAF. This is mainly due to 
      the heterogeneity of the methodology and groups analysed in the research. More 
      research in this area is needed.
FAU - Miadlikowska, Ewa
AU  - Miadlikowska E
AD  - Department of Pneumology, Medical University of Lodz, 90-153 Lodz, Poland.
FAU - Rzepka-Wrona, Patrycja
AU  - Rzepka-Wrona P
AD  - Department of Pneumonology, School of Medicine in Katowice, Medical University of 
      Silesia, 40-055 Katowice, Poland.
FAU - Milkowska-Dymanowska, Joanna
AU  - Milkowska-Dymanowska J
AD  - Department of Pneumology, Medical University of Lodz, 90-153 Lodz, Poland.
FAU - Bialas, Adam Jerzy
AU  - Bialas AJ
AD  - Department of Pathobiology of Respiratory Diseases, Medical University of Lodz, 
      90-153 Lodz, Poland.
FAU - Piotrowski, Wojciech Jerzy
AU  - Piotrowski WJ
AUID- ORCID: 0000-0003-4506-6006
AD  - Department of Pneumology, Medical University of Lodz, 90-153 Lodz, Poland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20211224
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC8745166
OTO - NOTNLM
OT  - CXCL
OT  - IPAF
OT  - KL-6
OT  - SP-A
OT  - SP-D
OT  - biomarkers
OT  - circulating fibrocytes
OT  - interstitial pneumonia with autoimmune features
OT  - pulmonary fibrosis
COIS- The authors declare that there is no conflict of interest according to this 
      study; however, there are some relationships between some authors and the 
      pharmaceutical industry, which should be mentioned: A.J.B. has consulted for 
      Chiesi company and received compensation and fees for lectures, also A.J.B. 
      received travel grants from Boehringer Ingelheim and Roche company; W.J.P. has 
      received fees for lectures, travel grants, and remuneration for participation in 
      advisory boards from Boehringer Ingelheim and Roche. The funders had no role in 
      the design of the study; in the collection, analyses, or interpretation of data; 
      in the writing of the manuscript, or in the decision to publish the results.
EDAT- 2022/01/12 06:00
MHDA- 2022/01/12 06:01
PMCR- 2021/12/24
CRDT- 2022/01/11 01:15
PHST- 2021/11/19 00:00 [received]
PHST- 2021/12/13 00:00 [revised]
PHST- 2021/12/21 00:00 [accepted]
PHST- 2022/01/11 01:15 [entrez]
PHST- 2022/01/12 06:00 [pubmed]
PHST- 2022/01/12 06:01 [medline]
PHST- 2021/12/24 00:00 [pmc-release]
AID - jcm11010079 [pii]
AID - jcm-11-00079 [pii]
AID - 10.3390/jcm11010079 [doi]
PST - epublish
SO  - J Clin Med. 2021 Dec 24;11(1):79. doi: 10.3390/jcm11010079.