PMID- 35012000
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220114
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 11
IP  - 1
DP  - 2022 Jan 4
TI  - 360 degrees  Ab-Interno Schlemm's Canal Viscodilation with OMNI Viscosurgical Systems for 
      Open-Angle Glaucoma-Midterm Results.
LID - 10.3390/jcm11010259 [doi]
LID - 259
AB  - PURPOSE: To evaluate the effectiveness of ab-interno microcatheterization and 
      360 degrees  viscodilation of Schlemm's canal (SC) performed with OMNI viscosurgical 
      system in open angle glaucoma (OAG) together or not with phacoemulsification. 
      SETTING: Two surgical sites. DESIGN: Retrospective, observational. METHODS: 
      Eighty eyes from 73 patients with mild to moderate OAG underwent ab- interno SC 
      viscodilation performed with OMNI system. Fifty eyes (Group 1) underwent only SC 
      viscodilation, while 30 eyes (Group 2) underwent glaucoma surgery + cataract 
      extraction. Primary success endpoint at 12 months was an intraocular pressure 
      (IOP) reduction higher than 25% from baseline with an absolute value of 18 mmHg 
      or lower, either on the same number or fewer ocular hypotensive medications, 
      without further interventions. Secondary effectiveness endpoints included mean 
      IOP, number of medications and comparison of outcomes between groups. Safety 
      endpoints consisted of best-corrected visual acuity (BCVA), adverse events (AEs), 
      and subsequent surgical procedures. RESULTS: Primary success was achieved in 
      40.0% and 67.9% in Groups 1 and 2, respectively. Mean IOP at 12-month follow-up 
      showed a significant reduction in both groups (from 23.0 to 15.6 mmHg, p < 0.001, 
      and from 21.5 to 14.1, p < 0.001, in Groups 1 and 2, respectively). Mean 
      medication number decreased in both groups (from 3.0 to 2.0, p < 0.001 and from 
      3.4 to 1.9, p < 0.001, in Groups 1 and 2, respectively). AEs included hyphema (2 
      eyes), mild hypotony (4 eyes), IOP spikes one month after surgery (1 eye). Twelve 
      eyes (15.0%) required subsequent surgical procedures. No BCVA reduction was 
      observed. CONCLUSIONS: Viscodilation of SC using OMNI viscosurgical systems is 
      safe and relatively effective in reducing IOP in adult patients with OAG.
FAU - Toneatto, Giacomo
AU  - Toneatto G
AUID- ORCID: 0000-0001-8994-1947
AD  - Department of Ophthalmology, University Hospital of Udine, 33100 Udine, Italy.
FAU - Zeppieri, Marco
AU  - Zeppieri M
AUID- ORCID: 0000-0003-0999-5545
AD  - Department of Ophthalmology, University Hospital of Udine, 33100 Udine, Italy.
FAU - Papa, Veronica
AU  - Papa V
AD  - Department of Ophthalmology, Policlinico "Citta di Udine", 33100 Udine, Italy.
FAU - Rizzi, Laura
AU  - Rizzi L
AUID- ORCID: 0000-0002-2470-3953
AD  - Department of Economics and Statistics, University of Udine, 33100 Udine, Italy.
FAU - Salati, Carlo
AU  - Salati C
AD  - Department of Ophthalmology, University Hospital of Udine, 33100 Udine, Italy.
FAU - Gabai, Andrea
AU  - Gabai A
AUID- ORCID: 0000-0002-3865-3336
AD  - Department of Ophthalmology, University Hospital of Udine, 33100 Udine, Italy.
FAU - Brusini, Paolo
AU  - Brusini P
AUID- ORCID: 0000-0003-0855-5775
AD  - Department of Ophthalmology, Policlinico "Citta di Udine", 33100 Udine, Italy.
LA  - eng
PT  - Journal Article
DEP - 20220104
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC8745878
OTO - NOTNLM
OT  - OMNI viscosurgical system
OT  - Schlemm's canal viscodilation
OT  - cataract extraction
OT  - minimally invasive glaucoma surgeries (MIGS)
OT  - open angle glaucoma (OAG)
OT  - trabeculotomy
COIS- The authors declare no conflict of interest.
EDAT- 2022/01/12 06:00
MHDA- 2022/01/12 06:01
PMCR- 2022/01/04
CRDT- 2022/01/11 01:16
PHST- 2021/11/09 00:00 [received]
PHST- 2021/12/06 00:00 [revised]
PHST- 2021/12/29 00:00 [accepted]
PHST- 2022/01/11 01:16 [entrez]
PHST- 2022/01/12 06:00 [pubmed]
PHST- 2022/01/12 06:01 [medline]
PHST- 2022/01/04 00:00 [pmc-release]
AID - jcm11010259 [pii]
AID - jcm-11-00259 [pii]
AID - 10.3390/jcm11010259 [doi]
PST - epublish
SO  - J Clin Med. 2022 Jan 4;11(1):259. doi: 10.3390/jcm11010259.