PMID- 35012576
OWN - NLM
STAT- MEDLINE
DCOM- 20220119
LR  - 20220119
IS  - 1824-7288 (Electronic)
IS  - 1720-8424 (Linking)
VI  - 48
IP  - 1
DP  - 2022 Jan 10
TI  - Altered microstructure of the splenium of corpus callosum is associated with 
      neurodevelopmental impairment in preterm infants with necrotizing enterocolitis.
PG  - 6
LID - 10.1186/s13052-021-01197-z [doi]
LID - 6
AB  - BACKGROUND: Necrotizing enterocolitis (NEC) is a devastating disease in preterm 
      infants with significant morbidities, including neurodevelopmental impairment 
      (NDI). This study aimed to investigate whether NEC is associated with (1) brain 
      volume expansion and white matter maturation using diffusion tensor imaging 
      analysis and (2) NDI compared with preterm infants without NEC. METHODS: We 
      included 86 preterm infants (20 with NEC and 66 without NEC) with no evidence of 
      brain abnormalities on trans-fontanelle ultrasonography and magnetic resonance 
      imaging at term-equivalent age (TEA). Regional brain volume analysis and white 
      matter tractography were performed to study brain microstructure alterations. NDI 
      was assessed using the Bayley Scales of Infant and Toddler Development-III 
      (BSID-III) at 18 months of corrected age (CA). RESULTS: Preterm infants with NEC 
      showed significantly high risk of motor impairment (odds ratio 58.26, 95% 
      confidence interval 7.80-435.12, p < 0.001). We found significantly increased 
      mean diffusivity (MD) in the splenium of corpus callosum (sCC) (p = 0.001) and 
      the left corticospinal tract (p = 0.001) in preterm infants with NEC. The sCC 
      with increased MD showed a negative association with the BSID-III language 
      (p = 0.025) and motor scores (p = 0.002) at 18 months of CA, implying the 
      relevance of sCC integrity with later NDI. CONCLUSION: The white matter 
      microstructure differed between preterm infants with and without NEC. The 
      prognostic value of network parameters of sCC at TEA may provide better 
      information for the early detection of NDI in preterm infants.
CI  - (c) 2022. The Author(s).
FAU - Cha, Jong Ho
AU  - Cha JH
AD  - Department of Pediatrics, Hanyang University College of Medicine, 222-1 
      Wangsimni-ro Seongdong-gu, Seoul, 04763, South Korea.
FAU - Lim, Jung-Sun
AU  - Lim JS
AD  - Department of Family Medicine, Kangbuk Samsung Hospital, School of Medicine, 
      Sungkyunkwan University, Seoul, South Korea.
FAU - Jang, Yong Hun
AU  - Jang YH
AD  - Department of Biomedical Engineering, Hanyang University, Seoul, South Korea.
AD  - Clinical Research Institute of Developmental Medicine, Seoul Hanyang University 
      Hospital, Seoul, South Korea.
FAU - Hwang, Jae Kyoon
AU  - Hwang JK
AD  - Department of Pediatrics, Hanyang University College of Medicine, 222-1 
      Wangsimni-ro Seongdong-gu, Seoul, 04763, South Korea.
FAU - Na, Jae Yoon
AU  - Na JY
AD  - Department of Pediatrics, Hanyang University College of Medicine, 222-1 
      Wangsimni-ro Seongdong-gu, Seoul, 04763, South Korea.
AD  - Clinical Research Institute of Developmental Medicine, Seoul Hanyang University 
      Hospital, Seoul, South Korea.
FAU - Lee, Jong-Min
AU  - Lee JM
AD  - Department of Biomedical Engineering, Hanyang University, Seoul, South Korea.
FAU - Lee, Hyun Ju
AU  - Lee HJ
AD  - Department of Pediatrics, Hanyang University College of Medicine, 222-1 
      Wangsimni-ro Seongdong-gu, Seoul, 04763, South Korea.
AD  - Clinical Research Institute of Developmental Medicine, Seoul Hanyang University 
      Hospital, Seoul, South Korea.
FAU - Ahn, Ja-Hye
AU  - Ahn JH
AD  - Department of Pediatrics, Hanyang University College of Medicine, 222-1 
      Wangsimni-ro Seongdong-gu, Seoul, 04763, South Korea. mdscully@gmail.com.
AD  - Clinical Research Institute of Developmental Medicine, Seoul Hanyang University 
      Hospital, Seoul, South Korea. mdscully@gmail.com.
LA  - eng
GR  - HY-2017/Hanyang University/
GR  - 2020M3E5D9080787/National Research Foundation of Korea Grant funded by the Korean 
      Government MSIT/
GR  - 2020R1F1A1048529/National Research Foundation of Korea Grant funded by the Korean 
      Government MSIT/
PT  - Journal Article
PT  - Observational Study
DEP - 20220110
PL  - England
TA  - Ital J Pediatr
JT  - Italian journal of pediatrics
JID - 101510759
SB  - IM
MH  - Corpus Callosum/*diagnostic imaging
MH  - Developmental Disabilities/*etiology
MH  - Diffusion Tensor Imaging
MH  - Enterocolitis, Necrotizing/*complications
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - *Infant, Premature
MH  - *Infant, Premature, Diseases
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Prospective Studies
MH  - Pyramidal Tracts/diagnostic imaging
PMC - PMC8750779
OTO - NOTNLM
OT  - Brain microstructure
OT  - Corpus callosum
OT  - Diffusion tensor imaging
OT  - Necrotizing enterocolitis
OT  - Neurodevelopmental impairment
OT  - The Bayley scales of infant and toddler development
OT  - Very-low-birth-weight infant
OT  - White matter tracts
COIS- The authors declare that they have no competing interests.
EDAT- 2022/01/12 06:00
MHDA- 2022/01/20 06:00
PMCR- 2022/01/10
CRDT- 2022/01/11 05:53
PHST- 2021/07/14 00:00 [received]
PHST- 2021/12/14 00:00 [accepted]
PHST- 2022/01/11 05:53 [entrez]
PHST- 2022/01/12 06:00 [pubmed]
PHST- 2022/01/20 06:00 [medline]
PHST- 2022/01/10 00:00 [pmc-release]
AID - 10.1186/s13052-021-01197-z [pii]
AID - 1197 [pii]
AID - 10.1186/s13052-021-01197-z [doi]
PST - epublish
SO  - Ital J Pediatr. 2022 Jan 10;48(1):6. doi: 10.1186/s13052-021-01197-z.