PMID- 35013956
OWN - NLM
STAT- MEDLINE
DCOM- 20220503
LR  - 20220503
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 29
IP  - 21
DP  - 2022 May
TI  - Mixed effects of perfluoroalkyl and polyfluoroalkyl substances exposure on 
      cognitive function among people over 60 years old from NHANES.
PG  - 32093-32104
LID - 10.1007/s11356-021-17789-5 [doi]
AB  - The relationship between perfluoroalkyl and polyfluoroalkyl substances (PFAS) and 
      cognitive function are inconsistent, and the mixed effects of PFAS on cognitive 
      function are still unclear. We aimed to evaluate the joint effects of PFAS on 
      cognitive function assessed using four tests as follows: the Consortium to 
      Establish a Registry for Alzheimer's Disease Immediate Recall Test (IRT), Delayed 
      Recall Test (DRT), the Animal Fluency Test (AFT), and the Digit Symbol 
      Substitution Test (DSST) in the US elderly. A total of 777 individuals aged >/= 60 
      from the National Health and Nutrition Examination Survey (NHANES) 2011-2014 were 
      included in this study. Multivariable logistic regression and Bayesian kernel 
      machine regression (BKMR) were constructed to estimate the overall and the 
      individual effects of PFAS exposure on cognitive function. There were 21.36%, 
      22.65%, 21.62%, and 21.24% participants with cognitive decline in IRT, DRT, AFT, 
      and DSST, respectively. After multivariable adjustment, perfluorooctanoic acid 
      (PFOA) was inversely associated with cognitive decline in IRT, DRT, and AFT, 
      while no significant association was observed between any other PFAS and 
      cognitive decline. Compared with the lowest quartile, the adjusted odds ratio of 
      cognitive decline with a 95% confidence interval (CI) for the highest quartile of 
      PFOA was 0.33 (95% CI: 0.15-0.69) in IRT, 0.50 (0.26-0.96) in DRT, and 0.45 
      (0.21-0.95) in AFT. In BKMR analysis, the overall effect of mixtures was 
      significantly protective on cognitive decline in IRT, of which PFOA made the 
      greatest contribution. The consistent protective effect in DRT and DSST was 
      observed when all the chemicals were at their 50th percentile or below it. No 
      significant interaction was observed among PFAS for cognitive function. These 
      findings suggested that PFAS mixture at a low level of current exposure of the US 
      population may have a protective effect on cognitive function.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Weng, Xueqiong
AU  - Weng X
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Liang, Huanzhu
AU  - Liang H
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Tan, Yuxuan
AU  - Tan Y
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Chen, Jingmin
AU  - Chen J
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Fei, Qiaoyuan
AU  - Fei Q
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Liu, Shan
AU  - Liu S
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Guo, Xinrong
AU  - Guo X
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Wen, Lin
AU  - Wen L
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Wu, Yingying
AU  - Wu Y
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Jing, Chunxia
AU  - Jing C
AUID- ORCID: 0000-0001-7333-4181
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China. 
      jcxphd@gmail.com.
AD  - Guangdong Key Laboratory of Environmental Exposure and Health, Jinan University, 
      Guangzhou, 510632, Guangdong, China. jcxphd@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20220111
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
SB  - IM
MH  - Aged
MH  - *Alkanesulfonic Acids
MH  - Animals
MH  - Bayes Theorem
MH  - Cognition
MH  - *Environmental Pollutants
MH  - *Fluorocarbons
MH  - Humans
MH  - Nutrition Surveys
OTO - NOTNLM
OT  - BKMR
OT  - Cognitive function
OT  - Elderly
OT  - Mixed effect
OT  - PFAS
OT  - Protective
EDAT- 2022/01/12 06:00
MHDA- 2022/05/04 06:00
CRDT- 2022/01/11 06:59
PHST- 2021/07/27 00:00 [received]
PHST- 2021/11/23 00:00 [accepted]
PHST- 2022/01/12 06:00 [pubmed]
PHST- 2022/05/04 06:00 [medline]
PHST- 2022/01/11 06:59 [entrez]
AID - 10.1007/s11356-021-17789-5 [pii]
AID - 10.1007/s11356-021-17789-5 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2022 May;29(21):32093-32104. doi: 
      10.1007/s11356-021-17789-5. Epub 2022 Jan 11.