PMID- 35014126
OWN - NLM
STAT- MEDLINE
DCOM- 20220831
LR  - 20220907
IS  - 1750-3639 (Electronic)
IS  - 1015-6305 (Print)
IS  - 1015-6305 (Linking)
VI  - 32
IP  - 5
DP  - 2022 Sep
TI  - Information theory approaches to improve glioma diagnostic workflows in surgical 
      neuropathology.
PG  - e13050
LID - 10.1111/bpa.13050 [doi]
LID - e13050
AB  - AIMS: Resource-strained healthcare ecosystems often struggle with the adoption of 
      the World Health Organization (WHO) recommendations for the classification of 
      central nervous system (CNS) tumors. The generation of robust clinical diagnostic 
      aids and the advancement of simple solutions to inform investment strategies in 
      surgical neuropathology would improve patient care in these settings. METHODS: We 
      used simple information theory calculations on a brain cancer simulation model 
      and real-world data sets to compare contributions of clinical, histologic, 
      immunohistochemical, and molecular information. An image noise assay was 
      generated to compare the efficiencies of different image segmentation methods in 
      H&E and Olig2 stained images obtained from digital slides. An auto-adjustable 
      image analysis workflow was generated and compared with neuropathologists for p53 
      positivity quantification. Finally, the density of extracted features of the 
      nuclei, p53 positivity quantification, and combined ATRX/age feature was used to 
      generate a predictive model for 1p/19q codeletion in IDH-mutant tumors. RESULTS: 
      Information theory calculations can be performed on open access platforms and 
      provide significant insight into linear and nonlinear associations between 
      diagnostic biomarkers. Age, p53, and ATRX status have significant information for 
      the diagnosis of IDH-mutant tumors. The predictive models may facilitate the 
      reduction of false-positive 1p/19q codeletion by fluorescence in situ 
      hybridization (FISH) testing. CONCLUSIONS: We posit that this approach provides 
      an improvement on the cIMPACT-NOW workflow recommendations for IDH-mutant tumors 
      and a framework for future resource and testing allocation.
CI  - (c) 2022 The Authors. Brain Pathology published by John Wiley & Sons Ltd on behalf 
      of International Society of Neuropathology.
FAU - Cevik, Lokman
AU  - Cevik L
AD  - Department of Pathology, The Ohio State University Wexner Medical Center, 
      Columbus, Ohio, USA.
FAU - Landrove, Marilyn Vazquez
AU  - Landrove MV
AD  - Mathematical Biosciences Institute, The Ohio State University, Columbus, Ohio, 
      USA.
FAU - Aslan, Mehmet Tahir
AU  - Aslan MT
AD  - Department of Pathology, The Ohio State University Wexner Medical Center, 
      Columbus, Ohio, USA.
FAU - Khammad, Vasilii
AU  - Khammad V
AD  - Peoples' Friendship University of Russia, Moscow, Russia.
FAU - Garagorry Guerra, Francisco Jose
AU  - Garagorry Guerra FJ
AD  - Facultad de Medicina, UdeLaR, Catedra de Anatomia Patologica, Hospital de 
      Clinicas Manuel Quintela, Universidad de la Republica, Uruguay.
FAU - Cabello-Izquierdo, Yolanda
AU  - Cabello-Izquierdo Y
AD  - Department of Pathology, The Ohio State University Wexner Medical Center, 
      Columbus, Ohio, USA.
FAU - Wang, Wesley
AU  - Wang W
AUID- ORCID: 0000-0001-7904-9015
AD  - Department of Pathology, The Ohio State University Wexner Medical Center, 
      Columbus, Ohio, USA.
FAU - Zhao, Jing
AU  - Zhao J
AD  - Department of Biomedical Informatics, The Ohio State University College of 
      Medicine, Columbus, Ohio, USA.
FAU - Becker, Aline Paixao
AU  - Becker AP
AUID- ORCID: 0000-0002-8695-810X
AD  - Department of Pathology, The Ohio State University Wexner Medical Center, 
      Columbus, Ohio, USA.
FAU - Czeisler, Catherine
AU  - Czeisler C
AD  - Department of Pathology, The Ohio State University Wexner Medical Center, 
      Columbus, Ohio, USA.
FAU - Rendeiro, Anne Costa
AU  - Rendeiro AC
AD  - Pathology Department, Barretos Cancer Hospital, Barretos, Brazil.
FAU - Veras, Lucas Luis Sousa
AU  - Veras LLS
AD  - Pathology Department, Barretos Cancer Hospital, Barretos, Brazil.
FAU - Zanon, Maicon Fernando
AU  - Zanon MF
AD  - Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil.
FAU - Reis, Rui Manuel
AU  - Reis RM
AUID- ORCID: 0000-0002-9639-7940
AD  - Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil.
AD  - Life and Health Sciences Research Institute (ICVS), School of Medicine, 
      University of Minho, Braga, Portugal.
FAU - Matsushita, Marcus de Medeiros
AU  - Matsushita MM
AD  - MultiPat Laboratorio de Anatomia Patologica, Campinas, Brazil.
FAU - Ozduman, Koray
AU  - Ozduman K
AD  - Department of Neurosurgery, Acibadem MAA University, Istanbul, Turkey.
FAU - Pamir, M Necmettin
AU  - Pamir MN
AD  - Department of Neurosurgery, Acibadem MAA University, Istanbul, Turkey.
FAU - Ersen Danyeli, Ayca
AU  - Ersen Danyeli A
AUID- ORCID: 0000-0001-8015-9916
AD  - Department of Pathology, Acibadem University School of Medicine, Istanbul, 
      Turkey.
FAU - Pearce, Thomas
AU  - Pearce T
AD  - Division of Neuropathology, Department of Pathology, University of Pittsburgh 
      Medical Center, Pittsburgh, Pennsylvania, USA.
FAU - Felicella, Michelle
AU  - Felicella M
AD  - Division of Neuropathology, Department of Pathology, University of Texas Medical 
      Branch, Galveston, Texas, USA.
FAU - Eschbacher, Jennifer
AU  - Eschbacher J
AD  - Department of Pathology, Barrow Neurological Institute, St. Joseph's Hospital and 
      Medical Center, Phoenix, Arizona, USA.
FAU - Arakaki, Naomi
AU  - Arakaki N
AD  - Departamento de Neuropatologia y Biologia Molecular, Instituto de Investigaciones 
      Neurologicas Dr Raul Carrea (FLENI), Buenos Aires, Argentina.
FAU - Martinetto, Horacio
AU  - Martinetto H
AD  - Departamento de Neuropatologia y Biologia Molecular, Instituto de Investigaciones 
      Neurologicas Dr Raul Carrea (FLENI), Buenos Aires, Argentina.
FAU - Parwani, Anil
AU  - Parwani A
AD  - Department of Pathology, The Ohio State University Wexner Medical Center, 
      Columbus, Ohio, USA.
FAU - Thomas, Diana L
AU  - Thomas DL
AD  - Department of Pathology, The Ohio State University Wexner Medical Center, 
      Columbus, Ohio, USA.
FAU - Otero, Jose Javier
AU  - Otero JJ
AUID- ORCID: 0000-0003-0680-4520
AD  - Department of Pathology, The Ohio State University Wexner Medical Center, 
      Columbus, Ohio, USA.
LA  - eng
SI  - figshare/10.6084/m9.figshare.16493964
GR  - R03 NS116334/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20220110
PL  - Switzerland
TA  - Brain Pathol
JT  - Brain pathology (Zurich, Switzerland)
JID - 9216781
RN  - 0 (Tumor Suppressor Protein p53)
RN  - EC 1.1.1.41 (Isocitrate Dehydrogenase)
SB  - IM
MH  - *Brain Neoplasms/pathology
MH  - Chromosome Aberrations
MH  - Chromosomes, Human, Pair 1
MH  - Chromosomes, Human, Pair 19
MH  - Ecosystem
MH  - *Glioma/pathology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Information Theory
MH  - Isocitrate Dehydrogenase/genetics
MH  - Mutation
MH  - Neuropathology
MH  - Tumor Suppressor Protein p53
MH  - Workflow
PMC - PMC9425010
OTO - NOTNLM
OT  - 1p/19q codeletion
OT  - cIMPACT
OT  - glioma
OT  - image segmentation
OT  - information theory
OT  - machine learning
COIS- The authors have no conflicts of interest to declare that are relevant to the 
      content of this article.
EDAT- 2022/01/12 06:00
MHDA- 2022/09/01 06:00
PMCR- 2022/01/10
CRDT- 2022/01/11 07:09
PHST- 2021/12/11 00:00 [revised]
PHST- 2021/09/22 00:00 [received]
PHST- 2021/12/15 00:00 [accepted]
PHST- 2022/01/12 06:00 [pubmed]
PHST- 2022/09/01 06:00 [medline]
PHST- 2022/01/11 07:09 [entrez]
PHST- 2022/01/10 00:00 [pmc-release]
AID - BPA13050 [pii]
AID - 10.1111/bpa.13050 [doi]
PST - ppublish
SO  - Brain Pathol. 2022 Sep;32(5):e13050. doi: 10.1111/bpa.13050. Epub 2022 Jan 10.