PMID- 35014229
OWN - NLM
STAT- MEDLINE
DCOM- 20220317
LR  - 20220317
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Print)
IS  - 1011-8934 (Linking)
VI  - 37
IP  - 2
DP  - 2022 Jan 10
TI  - Risk of Pregnancy Complications and Low Birth Weight Offsprings in Korean Women 
      With Rheumatic Diseases: A Nationwide Population-Based Study.
PG  - e18
LID - 10.3346/jkms.2022.37.e18 [doi]
LID - e18
AB  - BACKGROUND: To determine the risk of pregnancy complications and adverse 
      offspring outcomes in Korean women with rheumatic diseases (RDs). METHODS: Women 
      aged 20-44 years with pregnancies ending in delivery were identified from the 
      National Health Insurance Service-National Health Information Database 
      (2009-2016). Women with RD including systemic lupus erythematosus (SLE), 
      seropositive rheumatoid arthritis (SPRA), and ankylosing spondylitis (AS) (n = 
      4,284) were age-matched with controls (n = 26,023). Outcome variables included 
      threatened abortion (TA), preterm birth (PB), preeclampsia/eclampsia (PE/E), 
      intrauterine growth retardation (IGR), urinary tract infection, low birth weight 
      (LBW) offsprings, and offspring death within 1 year of birth. RESULTS: Women with 
      RDs had increased risks for cesarean section delivery (odds ratio [OR], 1.5; 95% 
      confidence interval [CI], 1.4-1.6), TA (OR, 1.4; 95% CI, 1.2-1.5), PB (OR, 2.4; 
      95% CI, 1.9-3.2), PE/E (OR, 4.4; 95% CI, 3.3-5.9), and IGR (OR, 2.4; 95% CI, 
      2.0-3.1) than the controls. The risk of pregnancy complications was increased in 
      SLE and SPRA pregnancies but not in AS pregnancies. Offsprings of women with RDs 
      had an increased risk of LBW (OR, 4.0; 95% CI, 3.2-4.9). The offspring mortality 
      rate within 1 year of birth was higher in women with RDs (6.2/10,000 persons) 
      than in the controls (4.9/10,000 persons). CONCLUSION: Women with RDs are at a 
      risk of developing pregnancy complications, and the risk of LBW offsprings and 
      offspring death within 1 year of birth is increased in these women. Therefore, 
      this population requires special attention during their childbearing years.
CI  - (c) 2021 The Korean Academy of Medical Sciences.
FAU - Park, Jin-Su
AU  - Park JS
AUID- ORCID: 0000-0002-4716-1149
AD  - Division of Rheumatology, Department of Internal Medicine, National Health 
      Insurance Service Ilsan Hospital, Goyang, Korea.
FAU - Chung, Min Kyung
AU  - Chung MK
AUID- ORCID: 0000-0001-6414-9187
AD  - Division of Rheumatology, Department of Internal Medicine, Ewha Womans University 
      College of Medicine, Seoul, Korea.
FAU - Lim, Hyunsun
AU  - Lim H
AUID- ORCID: 0000-0003-2391-3286
AD  - Research and Analysis Team, National Health Insurance Service Ilsan Hospital, 
      Goyang, Korea.
FAU - Lee, Jisoo
AU  - Lee J
AUID- ORCID: 0000-0001-6279-7025
AD  - Division of Rheumatology, Department of Internal Medicine, Ewha Womans University 
      College of Medicine, Seoul, Korea. leejisoo@ewha.ac.kr.
FAU - Lee, Chan Hee
AU  - Lee CH
AUID- ORCID: 0000-0001-5942-9029
AD  - Division of Rheumatology, Department of Internal Medicine, National Health 
      Insurance Service Ilsan Hospital, Goyang, Korea. chanhee@nhimc.or.kr.
LA  - eng
GR  - 2018-20-002/National Health Insurance Ilsan Hospital/Korea
GR  - NHIS-2020-1-407/National Health Information Database/Korea
PT  - Journal Article
DEP - 20220110
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
SB  - IM
MH  - Adult
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Infant, Low Birth Weight
MH  - Infant, Newborn
MH  - Pregnancy
MH  - Pregnancy Complications/*epidemiology/*etiology
MH  - Republic of Korea
MH  - Retrospective Studies
MH  - Rheumatic Diseases/*complications
MH  - Risk Assessment
MH  - Young Adult
PMC - PMC8748664
OTO - NOTNLM
OT  - Ankylosing Spondylitis
OT  - Health Services Research
OT  - Pregnancy
OT  - Rheumatoid Arthritis
OT  - Systemic Lupus Erythematosus
EDAT- 2022/01/12 06:00
MHDA- 2022/03/18 06:00
PMCR- 2022/01/10
CRDT- 2022/01/11 07:17
PHST- 2021/09/24 00:00 [received]
PHST- 2021/11/18 00:00 [accepted]
PHST- 2022/01/11 07:17 [entrez]
PHST- 2022/01/12 06:00 [pubmed]
PHST- 2022/03/18 06:00 [medline]
PHST- 2022/01/10 00:00 [pmc-release]
AID - 37.e18 [pii]
AID - 10.3346/jkms.2022.37.e18 [doi]
PST - epublish
SO  - J Korean Med Sci. 2022 Jan 10;37(2):e18. doi: 10.3346/jkms.2022.37.e18.