PMID- 35015933
OWN - NLM
STAT- MEDLINE
DCOM- 20220207
LR  - 20220207
IS  - 1555-2101 (Electronic)
IS  - 0160-6689 (Linking)
VI  - 83
IP  - 1
DP  - 2022 Jan 11
TI  - Mortality and Suicide Related to Major Depressive Disorder Before and After Type 
      2 Diabetes Mellitus.
LID - 20m13692 [pii]
LID - 10.4088/JCP.20m13692 [doi]
AB  - Objective: This study investigated differences in suicide and all-cause mortality 
      from ICD-9-CM comorbid major depressive disorder (MDD) and type 2 diabetes 
      mellitus (T2DM) depending on which was diagnosed first. Methods: A longitudinal 
      administrative claims database including 2 million samples and national death 
      registry data from 2000 through 2015 in Taiwan were used. Patients with newly 
      diagnosed T2DM were identified and further classified into 3 groups: (1) MDD 
      before T2DM, (2) T2DM without any diagnosis of MDD (from which matched controls 
      were selected), and (3) MDD after T2DM, based on the sequential occurrence dates 
      between incident T2DM and MDD. Multivariable Cox proportional hazard models were 
      analyzed. Results: Both the MDD before T2DM and MDD after T2DM groups had 
      significantly higher risks of all-cause mortality (adjusted hazard ratio 
      [AHR] = 1.21; 95% CI, 1.08-1.35 and AHR = 1.55; 95% CI, 1.45-1.66, respectively) 
      and committed suicide (AHR = 5.05; 95% CI, 2.46-10.37and AHR = 14.32; 95% CI, 
      7.44-27.55, respectively) than their matched controls, while the MDD before T2DM 
      and MDD after T2DM groups exhibited differences in mortality (significant; 
      P < .0001) and death by suicide (nonsignificant). Conclusions: The study findings 
      indicated suicide and mortality rates were higher in both the MDD before and MDD 
      after T2DM groups when compared with matched controls. Public health initiatives 
      are needed to survey and treat comorbid MDD with T2DM. Furthermore, additional 
      studies are needed to clarify the underlying pathophysiology of the association 
      between MDD and T2DM to find better suicide prevention strategies among those 
      high-risk patients who have comorbid T2DM and MDD.
CI  - (c) Copyright 2022 Physicians Postgraduate Press, Inc.
FAU - Huang, Chun-Jen
AU  - Huang CJ
AD  - Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung, 
      Taiwan.
AD  - Department of Psychiatry, Faculty of Medicine, College of Medicine, Kaohsiung 
      Medical University, Kaohsiung, Taiwan.
FAU - Huang, Yu-Ting
AU  - Huang YT
AD  - Division of Medical Statistics and Bioinformatics, Department of Medical 
      Research, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 
      Kaohsiung, Taiwan.
FAU - Lin, Pai-Cheng
AU  - Lin PC
AD  - Department of Psychiatry, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical 
      University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
FAU - Hsieh, Hui-Min
AU  - Hsieh HM
AD  - Department of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan.
AD  - Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, 
      Taiwan.
AD  - Department of Community Medicine, Kaohsiung Medical University Hospital, 
      Kaohsiung, Taiwan.
AD  - Center for Big Data Research, Kaohsiung Medical University, Kaohsiung, Taiwan.
AD  - Equal contribution.
FAU - Yang, Yi-Hsin
AU  - Yang YH
AD  - National Institute of Cancer Research, National Health Research Institutes, 
      Tainan, Taiwan.
AD  - Equal contribution.
AD  - Corresponding author: Yi-Hsin Yang, PhD, National Institute of Cancer Research, 
      National Health Research Institutes, Taiwan, No.367, Sheng-Li Rd, North District, 
      Tainan, 70456 Taiwan (yhyang@nhri.edu.tw). ORCID: 0000-0002-9581-2778.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220111
PL  - United States
TA  - J Clin Psychiatry
JT  - The Journal of clinical psychiatry
JID - 7801243
SB  - IM
MH  - Adult
MH  - Aged
MH  - Comorbidity
MH  - Databases, Factual
MH  - Depressive Disorder, Major/*mortality
MH  - Diabetes Mellitus, Type 2/*mortality
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Proportional Hazards Models
MH  - Registries
MH  - Risk Factors
MH  - Suicide/*statistics & numerical data
MH  - Taiwan/epidemiology
EDAT- 2022/01/12 06:00
MHDA- 2022/02/08 06:00
CRDT- 2022/01/11 17:46
PHST- 2022/01/11 17:46 [entrez]
PHST- 2022/01/12 06:00 [pubmed]
PHST- 2022/02/08 06:00 [medline]
AID - 20m13692 [pii]
AID - 10.4088/JCP.20m13692 [doi]
PST - epublish
SO  - J Clin Psychiatry. 2022 Jan 11;83(1):20m13692. doi: 10.4088/JCP.20m13692.