PMID- 35016008
OWN - NLM
STAT- MEDLINE
DCOM- 20220411
LR  - 20220411
IS  - 1879-0445 (Electronic)
IS  - 0960-9822 (Linking)
VI  - 32
IP  - 4
DP  - 2022 Feb 28
TI  - Different encoding of reward location in dorsal and intermediate hippocampus.
PG  - 834-841.e5
LID - S0960-9822(21)01700-0 [pii]
LID - 10.1016/j.cub.2021.12.024 [doi]
AB  - Hippocampal place cells fire at specific locations in the environment. They form 
      a cognitive map that encodes spatial relations in the environment, including 
      reward locations.(1) As part of this encoding, dorsal CA1 (dCA1) place cells 
      accumulate at reward.(2-5) The encoding of learned reward location could vary 
      between the dorsal and intermediate hippocampus, which differ in gene expression 
      and cortical and subcortical connectivity.(6) While the dorsal hippocampus is 
      critical for spatial navigation, the involvement of intermediate CA1 (iCA1) in 
      spatial navigation might depend on task complexity(7) and learning phase.(8-10) 
      The intermediate-to-ventral hippocampus regulates reward-seeking,(11-15) but 
      little is known about the involvement in reward-directed navigation. Here, we 
      compared the encoding of learned reward locations in dCA1 and iCA1 during spatial 
      navigation. We used calcium imaging with a head-mounted microscope to track the 
      activity of CA1 cells over multiple days during which mice learned different 
      reward locations. In dCA1, the fraction of active place cells increased in 
      anticipation of reward, but the pool of active cells changed with the reward 
      location. In iCA1, the same cells anticipated multiple reward locations. Our 
      results support a model in which the dCA1 cognitive map incorporates a changing 
      population of cells that encodes reward proximity through increased population 
      activity, while iCA1 provides a reward-predictive code through a dedicated 
      subpopulation. Both of these location-invariant codes persisted over time, and 
      together they provide a dual hippocampal reward location code, assisting 
      goal-directed navigation.(16)(,)(17).
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Jarzebowski, Przemyslaw
AU  - Jarzebowski P
AD  - Department of Physiology, Development and Neuroscience, Physiological Laboratory, 
      Cambridge CB2 3EG, UK.
FAU - Hay, Y Audrey
AU  - Hay YA
AD  - Department of Physiology, Development and Neuroscience, Physiological Laboratory, 
      Cambridge CB2 3EG, UK.
FAU - Grewe, Benjamin F
AU  - Grewe BF
AD  - Institute of Neuroinformatics, University and ETH Zurich, Winterthurerstrasse 
      190, Zurich, Switzerland.
FAU - Paulsen, Ole
AU  - Paulsen O
AD  - Department of Physiology, Development and Neuroscience, Physiological Laboratory, 
      Cambridge CB2 3EG, UK. Electronic address: op210@cam.ac.uk.
LA  - eng
GR  - BB/P019560/1/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220110
PL  - England
TA  - Curr Biol
JT  - Current biology : CB
JID - 9107782
RN  - 0 (Autoantigens)
RN  - 0 (Ica1 protein, mouse)
SB  - IM
MH  - Animals
MH  - Autoantigens
MH  - CA1 Region, Hippocampal/physiology
MH  - Hippocampus/physiology
MH  - Mice
MH  - *Place Cells/physiology
MH  - Reward
MH  - *Spatial Navigation/physiology
OTO - NOTNLM
OT  - CA1
OT  - calcium imaging
OT  - dorsal hippocampus
OT  - intemediate hippocampus
OT  - learning
OT  - navigation
OT  - place cells
OT  - reward memory
COIS- Declaration of interests The authors declare no competing interests.
EDAT- 2022/01/12 06:00
MHDA- 2022/04/12 06:00
CRDT- 2022/01/11 20:08
PHST- 2021/09/07 00:00 [received]
PHST- 2021/11/05 00:00 [revised]
PHST- 2021/12/08 00:00 [accepted]
PHST- 2022/01/12 06:00 [pubmed]
PHST- 2022/04/12 06:00 [medline]
PHST- 2022/01/11 20:08 [entrez]
AID - S0960-9822(21)01700-0 [pii]
AID - 10.1016/j.cub.2021.12.024 [doi]
PST - ppublish
SO  - Curr Biol. 2022 Feb 28;32(4):834-841.e5. doi: 10.1016/j.cub.2021.12.024. Epub 
      2022 Jan 10.