PMID- 35016153 OWN - NLM STAT- MEDLINE DCOM- 20220328 LR - 20220328 IS - 1872-9800 (Electronic) IS - 0969-8043 (Linking) VI - 181 DP - 2022 Mar TI - Synchronous bilateral breast carcinoma irradiation: A comparative investigation between flattened and unflattened beams. PG - 110079 LID - S0969-8043(21)00470-X [pii] LID - 10.1016/j.apradiso.2021.110079 [doi] AB - Synchronous bilateral breast carcinoma (SBBC) radiotherapy is a very complicated and time-consuming process. Considering the advantages of unflattened (FFF) beams at a high dose rate, this work investigated the feasibility of FFF beam application in SBBC radiotherapy and compared the advantages between FFF and flattened (FF) beams. CT images of 13 patients with SBBC were retrospectively collected to design intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) plans using FF and FFF beams. Dosimetric verification was applied for each plan. The target volume metrics, dose received by organs at risk (OARs), and delivery parameter of the plans were documented. All plans met the universal tolerance limits in dosimetric verification. FFF decreased the volume to receive 5 Gy (V(5Gy)), V(7Gy), and mean dose of the left lung but slightly increased the V(30Gy) of the liver for VMAT and decreased the V(17Gy) and V(20Gy) of the right lung for IMRT. No remarkable differences between FF and FFF were found in the other investigated OARs and all the investigated target volume metrics. The mean treatment times of FFF were 66 and 45 s shorter than those of FF for IMRT and VMAT, respectively. FFF beams were feasible and had advantages in reducing treatment time and protecting the lung while maintaining the target volume metrics in SBBC irradiation. CI - Copyright (c) 2022 Elsevier Ltd. All rights reserved. FAU - Duan, Song AU - Duan S AD - Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China; Department of Radiation Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. FAU - Li, Chengwen AU - Li C AD - Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China; Department of Radiation Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. FAU - Shi, Juntian AU - Shi J AD - Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China; Department of Radiation Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. FAU - Ma, Yujia AU - Ma Y AD - Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China; Department of Radiation Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. FAU - Zhang, Xingxing AU - Zhang X AD - Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China; Department of Radiation Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. FAU - Huang, Jianghua AU - Huang J AD - Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China; Department of Radiation Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. FAU - Wu, Xiuxiu AU - Wu X AD - Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China; Department of Radiation Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. FAU - Lin, Xiao AU - Lin X AD - Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China; Department of Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. FAU - Huang, Xiaobo AU - Huang X AD - Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China; Department of Radiation Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China; Department of Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. Electronic address: huangxbo@mail.sysu.edu.cn. LA - eng PT - Comparative Study PT - Journal Article DEP - 20220105 PL - England TA - Appl Radiat Isot JT - Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine JID - 9306253 SB - IM MH - Adult MH - Aged MH - Breast Neoplasms/*radiotherapy MH - Female MH - Humans MH - Middle Aged MH - Organs at Risk/radiation effects MH - Radiation Tolerance MH - Radiotherapy Dosage MH - Radiotherapy Planning, Computer-Assisted/*methods MH - Radiotherapy, Intensity-Modulated/*methods MH - Retrospective Studies OTO - NOTNLM OT - Organs at risk OT - Synchronous bilateral breast carcinoma radiotherapy OT - Target volume metrics OT - Treatment time OT - Unflattened beams EDAT- 2022/01/12 06:00 MHDA- 2022/03/29 06:00 CRDT- 2022/01/11 20:17 PHST- 2021/09/13 00:00 [received] PHST- 2021/12/18 00:00 [revised] PHST- 2021/12/21 00:00 [accepted] PHST- 2022/01/12 06:00 [pubmed] PHST- 2022/03/29 06:00 [medline] PHST- 2022/01/11 20:17 [entrez] AID - S0969-8043(21)00470-X [pii] AID - 10.1016/j.apradiso.2021.110079 [doi] PST - ppublish SO - Appl Radiat Isot. 2022 Mar;181:110079. doi: 10.1016/j.apradiso.2021.110079. Epub 2022 Jan 5.