PMID- 35016442
OWN - NLM
STAT- MEDLINE
DCOM- 20220113
LR  - 20220531
IS  - 2224-5839 (Electronic)
IS  - 2224-5820 (Linking)
VI  - 10
IP  - 12
DP  - 2021 Dec
TI  - Study on the relationship between the expression of S100A12, CaSR, and IL-7R in 
      the synovium of knee osteoarthritis and angiogenesis.
PG  - 12775-12781
LID - 10.21037/apm-21-3506 [doi]
AB  - BACKGROUND: To analyze the relationship between the expression of calcium binding 
      protein (S100A12), calcium sensitive receptor (CaSR), and interleukin-7 receptor 
      (IL-7R) in the synovium of knee osteoarthritis (KOA) and angiogenesis. METHODS: 
      The clinical data of 92 patients with KOA admitted to Sichuan Provincial People's 
      Hospital from February 2019 to May 2020 were collected (KOA group, 
      Kellgren-Lawrence staging: 23 cases of grade 2, 49 cases of grade 3, and 20 cases 
      of grade 4). In addition, 87 cases of patients with normal knee cartilage that 
      were not involved during the same period of treatment in this hospital were 
      selected. The expressions of S100A12, CaSR, IL-7R, and microvascular density 
      (MVD) were compared among different populations, and the correlation between 
      S100A12, CaSR, IL-7R, and MVD, and its diagnostic value for KOA were analyzed. 
      RESULTS: The values of S100A12, CaSR, IL-7R, and MVD in the KOA group were 
      significantly higher than those in the control group (P<0.05); the values of 
      S100A12, CaSR, and IL-7R in grade 4 patients were significantly higher than those 
      in grade 2 and 3 patients (P<0.05); S100A12, CaSR, IL-7R, and MVD were all 
      positively correlated, and the difference was statistically significant (P<0.05). 
      According to the receiver operating characteristic (ROC) curve, the area under 
      the curve (AUC) of S100A12, CaSR, and IL-7R for KOA diagnosis was 0.982, 0.929, 
      and 0.899, respectively. The Youden index was 0.630, 0.835, 0.739, respectively. 
      CONCLUSIONS: The expression levels of S100A12, CaSR, and IL-7R in the synovium of 
      KOA are significantly up-regulated, and they are closely related to angiogenesis.
FAU - Xu, Min
AU  - Xu M
AD  - Orthopedics of Traditional Chinese Medicine, Sichuan Provincial People's 
      Hospital, University of Electronic Science and Technology of China, Chengdu, 
      China; Chinese Academy of Sciences, Sichuan Translational Medicine Research 
      Hospital, Chengdu, China.
FAU - Tu, Jia
AU  - Tu J
AD  - Orthopedics of Traditional Chinese Medicine, Sichuan Provincial People's 
      Hospital, University of Electronic Science and Technology of China, Chengdu, 
      China; Chinese Academy of Sciences, Sichuan Translational Medicine Research 
      Hospital, Chengdu, China.
FAU - Yang, Yanwei
AU  - Yang Y
AD  - Orthopedics of Traditional Chinese Medicine, Sichuan Provincial People's 
      Hospital, University of Electronic Science and Technology of China, Chengdu, 
      China; Chinese Academy of Sciences, Sichuan Translational Medicine Research 
      Hospital, Chengdu, China.
FAU - Zou, Wenjuan
AU  - Zou W
AD  - Orthopedics of Traditional Chinese Medicine, Sichuan Provincial People's 
      Hospital, University of Electronic Science and Technology of China, Chengdu, 
      China; Chinese Academy of Sciences, Sichuan Translational Medicine Research 
      Hospital, Chengdu, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Ann Palliat Med
JT  - Annals of palliative medicine
JID - 101585484
RN  - 0 (CASR protein, human)
RN  - 0 (Receptors, Calcium-Sensing)
RN  - 0 (Receptors, Interleukin-7)
RN  - 0 (S100A12 Protein)
RN  - 0 (S100A12 protein, human)
SB  - IM
MH  - Humans
MH  - *Osteoarthritis, Knee
MH  - ROC Curve
MH  - Receptors, Calcium-Sensing
MH  - Receptors, Interleukin-7
MH  - *S100A12 Protein
MH  - Synovial Membrane
OTO - NOTNLM
OT  - CaSR
OT  - IL-7R
OT  - S100A12
OT  - angiogenesis
OT  - knee osteoarthritis (KOA)
EDAT- 2022/01/13 06:00
MHDA- 2022/01/14 06:00
CRDT- 2022/01/12 01:00
PHST- 2021/11/11 00:00 [received]
PHST- 2021/12/16 00:00 [accepted]
PHST- 2022/01/12 01:00 [entrez]
PHST- 2022/01/13 06:00 [pubmed]
PHST- 2022/01/14 06:00 [medline]
AID - 10.21037/apm-21-3506 [doi]
PST - ppublish
SO  - Ann Palliat Med. 2021 Dec;10(12):12775-12781. doi: 10.21037/apm-21-3506.