PMID- 35016591
OWN - NLM
STAT- MEDLINE
DCOM- 20220318
LR  - 20220318
IS  - 1532-2513 (Electronic)
IS  - 0892-3973 (Linking)
VI  - 44
IP  - 2
DP  - 2022 Apr
TI  - Immunosuppressive effects of dimethyl fumarate on dendritic cell maturation and 
      migration: a potent protector for coronary heart disease.
PG  - 178-185
LID - 10.1080/08923973.2021.2025245 [doi]
AB  - Dendritic cells (DCs), as a bridge between innate and adaptive immunity, play key 
      roles in atherogenesis, particularly in plaque rupture, the underlying 
      pathophysiologic cause of myocardial infarction. Targeting DC functions, 
      including maturation and migration to atherosclerotic plaques, may be a novel 
      therapeutic approach to atherosclerotic disease. Dimethyl fumarate (DMF), an 
      agent consisting of a combination of fumaric acid esters, in current study were 
      found to be able to suppress DC maturation by reducing the expression of 
      costimulatory molecules and MHC class II and by blocking cytokine secretion. In 
      addition, DMF efficiently inhibited the migration of activated DCs in vitro and 
      in vivo by reducing the expression of chemokine receptor 7 (CCR7). Additionally, 
      DMF efficiently inhibited the expression of the costimulatory molecule CD86, as 
      well as the chemokine receptor CCR7 and the C-X-C motif chemokine receptor 4 
      (CXCR4), in healthy donor-derived purified DCs that had been stimulated by 
      ST-segment elevation myocardial infarction (STEMI) patient serum. This study 
      points to the potent therapeutic value of DMF for protecting against 
      cardiovascular disease by suppressing DC functions.
FAU - Sun, Zikai
AU  - Sun Z
AD  - Department of Cardiology, Shanghai General Hospital of Nanjing Medical 
      University, Shanghai, China.
AD  - Department of Cardiology, The Affiliated Changzhou No.2 People's Hospital of 
      Nanjing Medical University, Changzhou, China.
FAU - Liu, Xiaoqiang
AU  - Liu X
AD  - Department of Cardiology, Shanghai General Hospital of Nanjing Medical 
      University, Shanghai, China.
FAU - Liu, Yu
AU  - Liu Y
AD  - Department of Cardiology, The Affiliated Changzhou No.2 People's Hospital of 
      Nanjing Medical University, Changzhou, China.
FAU - Zhao, Xin
AU  - Zhao X
AD  - Department of Cardiology, Zhujiang Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Zang, Xuan
AU  - Zang X
AD  - Department of Cardiology, The Affiliated Changzhou No.2 People's Hospital of 
      Nanjing Medical University, Changzhou, China.
FAU - Wang, Fang
AU  - Wang F
AD  - Department of Cardiology, Shanghai General Hospital of Nanjing Medical 
      University, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20220112
PL  - England
TA  - Immunopharmacol Immunotoxicol
JT  - Immunopharmacology and immunotoxicology
JID - 8800150
RN  - FO2303MNI2 (Dimethyl Fumarate)
SB  - IM
MH  - Cell Differentiation
MH  - Cell Movement
MH  - *Coronary Disease
MH  - Dendritic Cells
MH  - *Dimethyl Fumarate/pharmacology
MH  - Humans
MH  - Signal Transduction
OTO - NOTNLM
OT  - Dendritic cells
OT  - coronary heart disease
OT  - dimethyl fumarate
OT  - migration
EDAT- 2022/01/13 06:00
MHDA- 2022/03/19 06:00
CRDT- 2022/01/12 05:36
PHST- 2022/01/13 06:00 [pubmed]
PHST- 2022/03/19 06:00 [medline]
PHST- 2022/01/12 05:36 [entrez]
AID - 10.1080/08923973.2021.2025245 [doi]
PST - ppublish
SO  - Immunopharmacol Immunotoxicol. 2022 Apr;44(2):178-185. doi: 
      10.1080/08923973.2021.2025245. Epub 2022 Jan 12.