PMID- 35019204 OWN - NLM STAT- MEDLINE DCOM- 20220429 LR - 20220512 IS - 1522-726X (Electronic) IS - 1522-1946 (Linking) VI - 99 IP - 5 DP - 2022 Apr TI - The impact of pulmonary hypertension on outcomes of transcatheter mitral valve replacement in mitral annular calcification. PG - 1647-1658 LID - 10.1002/ccd.30057 [doi] AB - OBJECTIVES: To assess the impact of pulmonary hypertension (PH) on outcomes of patients with severe mitral annular calcification (MAC) undergoing transcatheter mitral valve replacement (TMVR). BACKGROUND: PH is associated with poor outcomes after mitral valve surgery. Whether the presence of PH in patients with MAC undergoing (TMVR) is associated with poor outcomes, is unknown. METHODS: Retrospective evaluation of 116 patients from 51 centers in 11 countries who underwent TMVR with valve in mitral annular calcification (ViMAC) using balloon-expandable aortic transcatheter valves (THVs) from September 2012 to March 2017. Pulmonary artery systolic blood pressure (PASP) by echocardiogram was available in 90 patients. The subjects were stratified based on PASP: No PH = PASP /=50 mmHg (n = 58). Clinical, procedural, and echocardiographic outcomes were assessed. RESULTS: Mean age was 72.7 (+/-12.8) years, 59 (65.6%) were female, Society of Thoracic Surgeons score was 15.8 + 11.8% and 90.0% where in New York Heart Association (NYHA) class III-IV. There was no significant difference in all-cause mortality at 30 days (no PH = 27.3%, mild-moderate PH = 19.0%, severe PH = 31.6%; p = 0.55) or at 1 year (no PH = 54.5%, mild-moderate PH = 38.1%, severe PH = 56.1%; p = 0.36). No difference in adverse events, NYHA class or amount of residual mitral regurgitation at 1 year were observed between the groups. CONCLUSION: This study suggests that the presence of PH in patients with predominantly mitral stenosis with MAC undergoing TMVR does not impact mortality or adverse events. Further studies are needed to fully understand the effect of PH in this group of patients. CI - (c) 2022 Wiley Periodicals LLC. FAU - Cajigas, Hector R AU - Cajigas HR AUID- ORCID: 0000-0002-6792-1280 AD - Division of Pulmonary and Critical Care, Mayo Clinic, Rochester, Minnesota, USA. FAU - Kaptzan, Tatiana AU - Kaptzan T AD - Cardiovascular Research Unit, Mayo Clinic, Rochester, Minnesota, USA. FAU - Lewis, Bradley AU - Lewis B AD - Division of Biostatistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA. FAU - El-Sabbagh, Abdallah AU - El-Sabbagh A AD - Department of Cardiovascular Diseases, Mayo Clinic, Jacksonville, Florida, USA. FAU - Al-Hijji, Mohammed AU - Al-Hijji M AD - Division of Cardiovascular Diseases, Heart Hospital, Hamad Medical Corporation, Doha, Qatar. FAU - Eleid, Mackram AU - Eleid M AUID- ORCID: 0000-0001-6082-5379 AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA. FAU - Alkhouli, Mohamad AU - Alkhouli M AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA. FAU - Wang, Dee Dee AU - Wang DD AUID- ORCID: 0000-0002-5784-9924 AD - Division of Cardiovascular Medicine, Center for Structural Heart Disease, Henry Ford Hospital, Detroit, Michigan, USA. FAU - Eng, Marvin AU - Eng M AD - Division of Cardiovascular Medicine, Center for Structural Heart Disease, Henry Ford Hospital, Detroit, Michigan, USA. FAU - Kodali, Susheel AU - Kodali S AD - Division of Cardiology, Columbia University Medical Center, New York, New York, USA. FAU - George, Isaac AU - George I AD - Department of Surgery, Columbia University Medical Center, New York, New York, USA. FAU - Chakravarty, Tarun AU - Chakravarty T AD - Division of Cardiology, Cedars Sinai Medical Center, Los Angeles, California, USA. FAU - Pershad, Ashish AU - Pershad A AUID- ORCID: 0000-0002-6424-4341 AD - Division of Cardiology, Chandler Regional and Mercy Gilbert Medical Center, Gilbert, Arizona, USA. FAU - O'Hair, Daniel AU - O'Hair D AD - Division of Cardiac Surgery, Aurora St. Luke's Medical Center, Milwaukee, Wisconsin, USA. FAU - Jones, Noah AU - Jones N AD - Division of Cardiology, Mount Carmel East Hospital, Columbus, Ohio, USA. FAU - Makkar, Raj AU - Makkar R AD - Division of Cardiovascular Medicine, Center for Structural Heart Disease, Henry Ford Hospital, Detroit, Michigan, USA. FAU - Reisman, Mark AU - Reisman M AD - Department of Medicine, University of Washington, Seattle, Washington, USA. FAU - Leon, Martin AU - Leon M AD - Division of Cardiology, Columbia University Medical Center, New York, New York, USA. FAU - O'Neill, William AU - O'Neill W AD - Division of Cardiovascular Diseases, Heart Hospital, Hamad Medical Corporation, Doha, Qatar. FAU - Rihal, Charanjit AU - Rihal C AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA. FAU - Guerrero, Mayra AU - Guerrero M AUID- ORCID: 0000-0002-9151-8096 AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA. LA - eng PT - Journal Article DEP - 20220112 PL - United States TA - Catheter Cardiovasc Interv JT - Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions JID - 100884139 SB - IM MH - Aged MH - *Calcinosis/complications/diagnostic imaging/surgery MH - Cardiac Catheterization/adverse effects MH - Female MH - *Heart Valve Diseases/surgery MH - *Heart Valve Prosthesis MH - *Heart Valve Prosthesis Implantation/adverse effects MH - Humans MH - *Hypertension, Pulmonary/diagnostic imaging/etiology/surgery MH - Male MH - Mitral Valve/diagnostic imaging/surgery MH - *Mitral Valve Insufficiency/diagnostic imaging/etiology/surgery MH - Retrospective Studies MH - Treatment Outcome OTO - NOTNLM OT - mitral annular calcification OT - pulmonary hypertension OT - transcatheter mitral valve replacement EDAT- 2022/01/13 06:00 MHDA- 2022/04/30 06:00 CRDT- 2022/01/12 08:55 PHST- 2021/11/12 00:00 [revised] PHST- 2021/10/04 00:00 [received] PHST- 2021/12/14 00:00 [accepted] PHST- 2022/01/13 06:00 [pubmed] PHST- 2022/04/30 06:00 [medline] PHST- 2022/01/12 08:55 [entrez] AID - 10.1002/ccd.30057 [doi] PST - ppublish SO - Catheter Cardiovasc Interv. 2022 Apr;99(5):1647-1658. doi: 10.1002/ccd.30057. Epub 2022 Jan 12.