PMID- 35019548
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220210
IS  - 2576-6422 (Electronic)
IS  - 2576-6422 (Linking)
VI  - 3
IP  - 11
DP  - 2020 Nov 16
TI  - Red Light-Triggered Polyethylene Glycol Deshielding from Photolabile 
      Cyanine-Modified Mesoporous Silica Nanoparticles for On-Demand Drug Release.
PG  - 8084-8093
LID - 10.1021/acsabm.0c01160 [doi]
AB  - PEGylation of drug delivery systems (DDSs) provides a promising approach to 
      overcome the side effect of traditional chemotherapy via the enhanced 
      permeability and retention (EPR) effect, although it further inhibits the 
      internalization behavior of nanocarriers. PEGylation/dePEGylation of the 
      nanocarriers at the desired site exhibits great advantages for nanocarrier-based 
      on-demand drug release. Here, we reported a photoinduced polyethylene glycol 
      (PEG) deshielding nanocarrier, SiO(2)@DOX-Cy-PEG, for on-demand drug release in 
      an acidic tumor microenvironment. SiO(2)@DOX nanoparticles were functionalized 
      with PEG-alkyne chains by click reaction with the photolabile cyanine-azide 
      linkers. Under red light irradiation (650 nm), doxorubicin (DOX) can be 
      effectively released from mesoporous silica nanoparticles (MSNs) due to the 
      photolysis of Cy, resulting in the cleavage of the linkers and PEG deshielding in 
      cancer cells. Therefore, SiO(2)@DOX-Cy-PEG nanoparticles with irradiation arouse 
      a higher cell apoptosis and death ratio, further proving that dePEGylation of 
      MSNs accelerates the release of DOX. In addition, the experiment of the antitumor 
      effect in vivo demonstrated that dePEGylation of the SiO(2)@DOX-Cy-PEG could 
      effectively promote the therapeutic effect on xenografted 4T1 tumor-bearing 
      BALB/c mice. The results suggested that SiO(2)@DOX-Cy-PEG was a precisely and 
      remotely on-demand drug delivery system controlled by red light.
FAU - Li, Xiaojing
AU  - Li X
AD  - State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 
      116024, China.
FAU - Sun, Wen
AU  - Sun W
AUID- ORCID: 0000-0003-4316-5350
AD  - State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 
      116024, China.
AD  - Ningbo Institute of Dalian University of Technology, Ningbo 315016, China.
FAU - Zhang, Zhen
AU  - Zhang Z
AD  - State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 
      116024, China.
FAU - Kang, Yao
AU  - Kang Y
AD  - State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 
      116024, China.
FAU - Fan, Jiangli
AU  - Fan J
AUID- ORCID: 0000-0003-4962-5186
AD  - State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 
      116024, China.
AD  - Ningbo Institute of Dalian University of Technology, Ningbo 315016, China.
FAU - Peng, Xiaojun
AU  - Peng X
AUID- ORCID: 0000-0002-8806-322X
AD  - State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 
      116024, China.
LA  - eng
PT  - Journal Article
DEP - 20201012
PL  - United States
TA  - ACS Appl Bio Mater
JT  - ACS applied bio materials
JID - 101729147
SB  - IM
OTO - NOTNLM
OT  - PEG deshielding
OT  - cyanine
OT  - drug release
OT  - mesoporous silica nanoparticles
OT  - red light-triggered
EDAT- 2020/11/16 00:00
MHDA- 2020/11/16 00:01
CRDT- 2022/01/12 12:17
PHST- 2022/01/12 12:17 [entrez]
PHST- 2020/11/16 00:00 [pubmed]
PHST- 2020/11/16 00:01 [medline]
AID - 10.1021/acsabm.0c01160 [doi]
PST - ppublish
SO  - ACS Appl Bio Mater. 2020 Nov 16;3(11):8084-8093. doi: 10.1021/acsabm.0c01160. 
      Epub 2020 Oct 12.