PMID- 35019822
OWN - NLM
STAT- MEDLINE
DCOM- 20220602
LR  - 20220711
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 63
IP  - 6
DP  - 2022 Jun
TI  - Specific TCR V-J gene segment recombinations leading to the identification 
      pan-V-J CDR3s associated with survival distinctions: diffuse large B-cell 
      lymphoma.
PG  - 1314-1322
LID - 10.1080/10428194.2021.2020781 [doi]
AB  - In the diffuse large B-cell lymphoma (DLBCL) setting, we examined lymph node 
      biopsy, T-cell receptor features, and the DLBLC patient human leukocyte antigen 
      (HLA) alleles, to provide a basis for assessing survival distinctions represented 
      by the National Cancer Institute Center for Cancer Research (NCICCR) dataset. 
      While previous analyses of other cancer datasets have indicated that specific 
      T-cell receptor (TCR) V or J gene segments, independently, can be associated with 
      a survival distinction, we have here identified V-J recombinations, representing 
      specific V and J gene segments associated with survival distinctions. As specific 
      V-J recombinations represent relatively conserved complementarity determining 
      region-3 (CDR3) amino acid sequences, we assessed the entire DLBCL NCICCR dataset 
      for such conserved CDR3 features. Overall, this approach indicated the 
      opportunity of identifying DLBCL patient subpopulations with TCR CDR3 features, 
      and HLA alleles, with significant survival distinctions, possibly identifying 
      cohorts more likely to benefit from a given immunotherapy.
FAU - Cios, Konrad J
AU  - Cios KJ
AD  - Department of Molecular Medicine, Morsani College of Medicine, University of 
      South Florida, Tampa, FL, USA.
FAU - Huda, Taha I
AU  - Huda TI
AD  - Department of Molecular Medicine, Morsani College of Medicine, University of 
      South Florida, Tampa, FL, USA.
FAU - Eakins, Rachel A
AU  - Eakins RA
AD  - Department of Molecular Medicine, Morsani College of Medicine, University of 
      South Florida, Tampa, FL, USA.
FAU - Mihyu, Moody M
AU  - Mihyu MM
AD  - Department of Molecular Medicine, Morsani College of Medicine, University of 
      South Florida, Tampa, FL, USA.
FAU - Blanck, George
AU  - Blanck G
AUID- ORCID: 0000-0003-1664-0996
AD  - Department of Molecular Medicine, Morsani College of Medicine, University of 
      South Florida, Tampa, FL, USA.
AD  - Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, 
      Tampa, FL, USA.
LA  - eng
PT  - Journal Article
DEP - 20220112
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (Complementarity Determining Regions)
RN  - 0 (Receptors, Antigen, T-Cell)
SB  - IM
MH  - Complementarity Determining Regions/genetics
MH  - Humans
MH  - *Lymphoma, Large B-Cell, Diffuse/diagnosis/genetics
MH  - *Receptors, Antigen, T-Cell/genetics
MH  - Recombination, Genetic
OTO - NOTNLM
OT  - Adaptive immune receptor recombinations
OT  - HLA alleles
OT  - V- and J-gene segments
OT  - complementarity determining region-3
OT  - diffuse large B-cell lymphoma survival rates
EDAT- 2022/01/13 06:00
MHDA- 2022/06/03 06:00
CRDT- 2022/01/12 12:23
PHST- 2022/01/13 06:00 [pubmed]
PHST- 2022/06/03 06:00 [medline]
PHST- 2022/01/12 12:23 [entrez]
AID - 10.1080/10428194.2021.2020781 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2022 Jun;63(6):1314-1322. doi: 10.1080/10428194.2021.2020781. Epub 
      2022 Jan 12.