PMID- 35019957
OWN - NLM
STAT- MEDLINE
DCOM- 20220913
LR  - 20220920
IS  - 2047-2412 (Electronic)
IS  - 2047-2404 (Linking)
VI  - 23
IP  - 10
DP  - 2022 Sep 10
TI  - Determinants of altered left ventricular suction in pre-capillary pulmonary 
      hypertension.
PG  - 1399-1406
LID - 10.1093/ehjci/jeab285 [doi]
AB  - AIMS: Although the left ventricular (LV) dysfunction in pre-capillary pulmonary 
      hypertension (PH) has been recently recognized, the mechanism of LV dysfunction 
      in this entity is not completely understood. We thus aimed to elucidate the 
      determinants of intraventricular pressure difference (IVPD), a measure of LV 
      suction, in pre-capillary PH. METHODS AND RESULTS: Right heart catheterization 
      and echocardiography were performed in 86 consecutive patients with pre-capillary 
      PH (57 +/- 18 years, 85% female). IVPD was determined using colour M-mode Doppler 
      to integrate the Euler equation. In overall, IVPD was reduced compared to 
      previously reported value in normal subjects. In univariable analyses, QRS 
      duration (P = 0.028), LV ejection fraction (P = 0.006), right ventricular (RV) 
      end-diastolic area (P < 0.001), tricuspid annular plane systolic excursion (P = 
      0.004), and LV early-diastolic eccentricity index (P = 0.009) were associated 
      with IVPD. In the multivariable analyses, RV end-diastolic area and LV 
      eccentricity index independently determined the IVPD. CONCLUSION: Aberrant 
      ventricular interdependence caused by RV enlargement could impair the LV suction. 
      This study first applied echocardiographic IVPD, a reliable marker of LV 
      diastolic suction, to investigate the mechanism of LV diastolic dysfunction in 
      pre-capillary PH.
CI  - Published on behalf of the European Society of Cardiology. All rights reserved. (c) 
      The Author(s) 2022. For permissions, please email: journals.permissions@oup.com.
FAU - Chiba, Yasuyuki
AU  - Chiba Y
AUID- ORCID: 0000-0002-2517-8441
AD  - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, 
      Japan.
FAU - Iwano, Hiroyuki
AU  - Iwano H
AUID- ORCID: 0000-0002-1267-8260
AD  - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, 
      Japan.
AD  - Division of Cardiology, Hakodate Municipal Hospital, 1-10-1, Minato-cho, Hakodate 
      041-8680, Japan.
FAU - Tsuneta, Satonori
AU  - Tsuneta S
AD  - Department of Diagnostic and Interventional Radiology, Hokkaido University 
      Hospital, Kita-14, Nishi-5, Kita-ku, Sapporo 060-8648, Japan.
FAU - Tsujinaga, Shingo
AU  - Tsujinaga S
AUID- ORCID: 0000-0002-5463-3458
AD  - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, 
      Japan.
FAU - Meyers, Brett
AU  - Meyers B
AD  - School of Mechanical Engineering, Purdue University, 585 Purdue Mall, West 
      Lafayette, IN 47907-2088, USA.
FAU - Vlachos, Pavlos
AU  - Vlachos P
AD  - School of Mechanical Engineering, Purdue University, 585 Purdue Mall, West 
      Lafayette, IN 47907-2088, USA.
FAU - Ishizaka, Suguru
AU  - Ishizaka S
AD  - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, 
      Japan.
FAU - Motoi, Ko
AU  - Motoi K
AD  - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, 
      Japan.
FAU - Aoyagi, Hiroyuki
AU  - Aoyagi H
AD  - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, 
      Japan.
FAU - Tamaki, Yoji
AU  - Tamaki Y
AD  - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, 
      Japan.
FAU - Tanemura, Asuka
AU  - Tanemura A
AD  - Diagnostic Center for Sonography, Hokkaido University Hospital, Kita-14, Nishi-5, 
      Kita-ku, Sapporo 060-8648, Japan.
FAU - Murayama, Michito
AU  - Murayama M
AUID- ORCID: 0000-0002-9249-9093
AD  - Diagnostic Center for Sonography, Hokkaido University Hospital, Kita-14, Nishi-5, 
      Kita-ku, Sapporo 060-8648, Japan.
FAU - Yokoyama, Shinobu
AU  - Yokoyama S
AD  - Division of Clinical Laboratory and Transfusion Medicine, Hokkaido University 
      Hospital, Kita-14, Nishi-5, Kita-ku, Sapporo 060-8648, Japan.
FAU - Nakabachi, Masahiro
AU  - Nakabachi M
AD  - Division of Clinical Laboratory and Transfusion Medicine, Hokkaido University 
      Hospital, Kita-14, Nishi-5, Kita-ku, Sapporo 060-8648, Japan.
FAU - Nishino, Hisao
AU  - Nishino H
AD  - Division of Clinical Laboratory and Transfusion Medicine, Hokkaido University 
      Hospital, Kita-14, Nishi-5, Kita-ku, Sapporo 060-8648, Japan.
FAU - Kaga, Sanae
AU  - Kaga S
AD  - Faculty of Health Sciences, Hokkaido University, Kita-12, Nishi-5, Kita-ku, 
      Sapporo 060-0812, Japan.
FAU - Kamiya, Kiwamu
AU  - Kamiya K
AD  - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, 
      Japan.
FAU - Ohira, Hiroshi
AU  - Ohira H
AD  - Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, 
      Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, Japan.
AD  - Division of Cardiology, KKR Sapporo Medical Center, 3-40, Hiragishi 1-6, 
      Toyohira-ku, Sapporo 062-0931, Japan.
FAU - Tsujino, Ichizo
AU  - Tsujino I
AD  - Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, 
      Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, Japan.
FAU - Anzai, Toshihisa
AU  - Anzai T
AD  - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, 
      Japan.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur Heart J Cardiovasc Imaging
JT  - European heart journal. Cardiovascular Imaging
JID - 101573788
SB  - IM
MH  - Diastole
MH  - Female
MH  - Heart Ventricles
MH  - Humans
MH  - *Hypertension, Pulmonary/diagnostic imaging/etiology
MH  - Male
MH  - Suction/adverse effects
MH  - *Ventricular Dysfunction, Left
MH  - *Ventricular Dysfunction, Right
MH  - Ventricular Pressure
OTO - NOTNLM
OT  - echocardiography
OT  - interventricular dependence
OT  - intraventricular pressure difference
OT  - pulmonary hypertension
COIS- Conflict of interest: none declared.
EDAT- 2022/01/13 06:00
MHDA- 2022/09/14 06:00
CRDT- 2022/01/12 12:30
PHST- 2021/10/14 00:00 [received]
PHST- 2021/12/14 00:00 [accepted]
PHST- 2022/01/13 06:00 [pubmed]
PHST- 2022/09/14 06:00 [medline]
PHST- 2022/01/12 12:30 [entrez]
AID - 6501543 [pii]
AID - 10.1093/ehjci/jeab285 [doi]
PST - ppublish
SO  - Eur Heart J Cardiovasc Imaging. 2022 Sep 10;23(10):1399-1406. doi: 
      10.1093/ehjci/jeab285.