PMID- 35021368
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220113
IS  - 2576-6422 (Electronic)
IS  - 2576-6422 (Linking)
VI  - 2
IP  - 3
DP  - 2019 Mar 18
TI  - A Bismuth Metal-Organic Framework as a Contrast Agent for X-ray Computed 
      Tomography.
PG  - 1197-1203
LID - 10.1021/acsabm.8b00778 [doi]
AB  - A new bismuth metal-organic framework (MOF), bismuth-NU-901 (Bi-NU-901), 
      featuring the scu topology and a pore with a diameter of  approximately 11 A, was 
      solvothermally synthesized, and its use as an X-ray computed tomography (CT) 
      contrast agent was tested. X-ray CT is a common diagnostic method used in the 
      medical field. Inside the body, contrast media enhance the distinction between 
      tissues and organs of similar density. Bi-NU-901 consists of eight connected 
      Bi(6) nodes and tetratopic 1,3,5,8-(p-benzoate)pyrene linkers (TBAPy). Numerous 
      material characterization studies including powder X-ray diffraction (PXRD), 
      scanning transmission electron microscopy (STEM), and DFT pore size distribution 
      support the scu structure. Additionally, given the framework's high density of 
      nontoxic heavy atoms, Bi-NU-901 was evaluated as an X-ray computed tomography 
      (CT) agent. Importantly, in vitro studies revealed this new bismuth MOF 
      demonstrates  approximately 7 times better contrast intensity compared to a zirconium MOF 
      featuring the same topology and  approximately 14 times better contrast than a commercially 
      available CT contrast agent. These results suggest bismuth MOFs may be promising 
      CT contrast agents.
FAU - Robison, Lee
AU  - Robison L
AUID- ORCID: 0000-0002-7419-4499
AD  - International Institute of Nanotechnology, Department of Chemistry, Northwestern 
      University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.
FAU - Zhang, Lin
AU  - Zhang L
AUID- ORCID: 0000-0001-5853-3107
AD  - International Institute of Nanotechnology, Department of Chemistry, Northwestern 
      University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.
AD  - College of Chemical Engineering, Nanjing Tech University, 5 Xinmofan Road, 
      Nanjing 210009, China.
FAU - Drout, Riki J
AU  - Drout RJ
AUID- ORCID: 0000-0002-3511-7597
AD  - International Institute of Nanotechnology, Department of Chemistry, Northwestern 
      University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.
FAU - Li, Peng
AU  - Li P
AUID- ORCID: 0000-0002-4273-4577
AD  - International Institute of Nanotechnology, Department of Chemistry, Northwestern 
      University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.
FAU - Haney, Chad R
AU  - Haney CR
AD  - Center for Advanced Molecular Imaging, Northwestern University, 2145 Sheridan 
      Road, Evanston, Illinois 60208-3113, United States.
FAU - Brikha, Anlil
AU  - Brikha A
AD  - Center for Advanced Molecular Imaging, Northwestern University, 2145 Sheridan 
      Road, Evanston, Illinois 60208-3113, United States.
FAU - Noh, Hyunho
AU  - Noh H
AUID- ORCID: 0000-0003-3136-1004
AD  - International Institute of Nanotechnology, Department of Chemistry, Northwestern 
      University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.
FAU - Mehdi, B Layla
AU  - Mehdi BL
AUID- ORCID: 0000-0002-8281-9524
AD  - School of Engineering, University of Liverpool, Liverpool, United Kingdom.
FAU - Browning, Nigel D
AU  - Browning ND
AD  - School of Engineering, University of Liverpool, Liverpool, United Kingdom.
FAU - Dravid, Vinayak P
AU  - Dravid VP
AUID- ORCID: 0000-0002-6007-3063
AD  - Department of Materials Science and Engineering, Northwestern University, 
      Evanston, Illinois 60208, United States.
FAU - Cui, Qun
AU  - Cui Q
AD  - College of Chemical Engineering, Nanjing Tech University, 5 Xinmofan Road, 
      Nanjing 210009, China.
FAU - Islamoglu, Timur
AU  - Islamoglu T
AUID- ORCID: 0000-0003-3688-9158
AD  - International Institute of Nanotechnology, Department of Chemistry, Northwestern 
      University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.
FAU - Farha, Omar K
AU  - Farha OK
AUID- ORCID: 0000-0002-9904-9845
AD  - International Institute of Nanotechnology, Department of Chemistry, Northwestern 
      University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.
LA  - eng
PT  - Journal Article
DEP - 20190215
PL  - United States
TA  - ACS Appl Bio Mater
JT  - ACS applied bio materials
JID - 101729147
SB  - IM
OTO - NOTNLM
OT  - X-ray computed tomography
OT  - bismuth
OT  - contrast agent
OT  - metal-organic frameworks
EDAT- 2019/03/18 00:00
MHDA- 2019/03/18 00:01
CRDT- 2022/01/13 01:00
PHST- 2022/01/13 01:00 [entrez]
PHST- 2019/03/18 00:00 [pubmed]
PHST- 2019/03/18 00:01 [medline]
AID - 10.1021/acsabm.8b00778 [doi]
PST - ppublish
SO  - ACS Appl Bio Mater. 2019 Mar 18;2(3):1197-1203. doi: 10.1021/acsabm.8b00778. Epub 
      2019 Feb 15.