PMID- 35021769
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220210
IS  - 2576-6422 (Electronic)
IS  - 2576-6422 (Linking)
VI  - 3
IP  - 9
DP  - 2020 Sep 21
TI  - Mesenchymal Stem Cell-Derived Exosomes for Treatment of Autism Spectrum Disorder.
PG  - 6384-6393
LID - 10.1021/acsabm.0c00831 [doi]
AB  - Recent breakthroughs in the field of stem cell therapy have brought hope to the 
      treatment of mental diseases. Animal experiments and clinical studies have shown 
      that transplantation of mesenchymal stem cells (MSCs) has a positive effect on 
      the treatment of autism spectrum disorder (ASD). However, the therapeutic 
      efficacy of the MSC transplants was primarily associated with the signals and 
      molecules secreted by the MSCs. Exosomes, for example, the secreted organelles 
      from MSCs, carry bioactive molecules of the MSCs that are essential for the 
      therapeutic effects in ASD treatment. This then inspires us to explore the 
      intranasal delivery of MSC exosomes to brain tissues for the treatment of ASD. 
      Exosomes from human umbilical cord mesenchymal stem cells (hUC-MSCs) that 
      efficiently enter the brain tissue through the intranasal route restore the 
      social ability of the mice and correct the repeated stereotyped behaviors and 
      other abnormal phenotypes in the offspring of valproic acid (VPA)-treated mice, 
      which show autism-like symptoms. The therapeutic efficacy can be attributed at 
      least partially to the anti-inflammatory effect of the MSC exosomes. This work 
      thereby reports brain-specific delivery of hUC-MSC exosomes, as a cell-free 
      therapy to relieve autism-related phenotypes, providing a promising direction for 
      the treatment of mental development disorders.
FAU - Liang, Yujie
AU  - Liang Y
AUID- ORCID: 0000-0002-0860-4859
AD  - Department of Child and Adolescent Psychiatry, Shenzhen Kangning Hospital, 
      Shenzhen Mental Health Center, Shenzhen Key Laboratory for Psychological 
      Healthcare & Shenzhen Institute of Mental Health, Shenzhen 518003, China.
AD  - Department of Chemistry, The Chinese University of Hong Kong, Shatin, Hong Kong 
      SAR, China.
FAU - Duan, Li
AU  - Duan L
AD  - Department of Orthopedics, Shenzhen Intelligent Orthopaedics and Biomedical 
      Innovation Platform, Guangdong Artificial Intelligence Biomedical Innovation 
      Platform, Shenzhen Second People's Hospital, the First Affiliated Hospital of 
      Shenzhen University Health Science Center, Shenzhen 518035, China.
FAU - Xu, Xiao
AU  - Xu X
AD  - Department of Orthopedics, Shenzhen Intelligent Orthopaedics and Biomedical 
      Innovation Platform, Guangdong Artificial Intelligence Biomedical Innovation 
      Platform, Shenzhen Second People's Hospital, the First Affiliated Hospital of 
      Shenzhen University Health Science Center, Shenzhen 518035, China.
FAU - Li, Xingfu
AU  - Li X
AD  - Department of Orthopedics, Shenzhen Intelligent Orthopaedics and Biomedical 
      Innovation Platform, Guangdong Artificial Intelligence Biomedical Innovation 
      Platform, Shenzhen Second People's Hospital, the First Affiliated Hospital of 
      Shenzhen University Health Science Center, Shenzhen 518035, China.
FAU - Liu, Min
AU  - Liu M
AD  - Department of Chemistry, The Chinese University of Hong Kong, Shatin, Hong Kong 
      SAR, China.
FAU - Chen, Hongfei
AU  - Chen H
AD  - Department of Chemistry, The Chinese University of Hong Kong, Shatin, Hong Kong 
      SAR, China.
FAU - Lu, Jianping
AU  - Lu J
AD  - Department of Child and Adolescent Psychiatry, Shenzhen Kangning Hospital, 
      Shenzhen Mental Health Center, Shenzhen Key Laboratory for Psychological 
      Healthcare & Shenzhen Institute of Mental Health, Shenzhen 518003, China.
AD  - School of Medicine Shenzhen University, Shenzhen 518035, China.
FAU - Xia, Jiang
AU  - Xia J
AUID- ORCID: 0000-0001-8112-7625
AD  - Department of Chemistry, The Chinese University of Hong Kong, Shatin, Hong Kong 
      SAR, China.
LA  - eng
PT  - Journal Article
DEP - 20200831
PL  - United States
TA  - ACS Appl Bio Mater
JT  - ACS applied bio materials
JID - 101729147
SB  - IM
OTO - NOTNLM
OT  - autism spectrum disorder
OT  - exosome
OT  - human umbilical cord mesenchymal stem cells
OT  - inflammation
OT  - intranasal
EDAT- 2020/09/21 00:00
MHDA- 2020/09/21 00:01
CRDT- 2022/01/13 05:32
PHST- 2022/01/13 05:32 [entrez]
PHST- 2020/09/21 00:00 [pubmed]
PHST- 2020/09/21 00:01 [medline]
AID - 10.1021/acsabm.0c00831 [doi]
PST - ppublish
SO  - ACS Appl Bio Mater. 2020 Sep 21;3(9):6384-6393. doi: 10.1021/acsabm.0c00831. Epub 
      2020 Aug 31.