PMID- 35022553
OWN - NLM
STAT- MEDLINE
DCOM- 20220712
LR  - 20221106
IS  - 1476-5640 (Electronic)
IS  - 0954-3007 (Linking)
VI  - 76
IP  - 7
DP  - 2022 Jul
TI  - Inflammatory markers as correlates of body composition and grip strength among 
      adults with and without HIV: A cross-sectional study in Ethiopia.
PG  - 973-978
LID - 10.1038/s41430-021-01056-4 [doi]
AB  - BACKGROUND: Changes in body composition and muscle strength are common among 
      individuals with HIV. We investigated the associations of inflammation with body 
      composition and grip strength in adults with and without HIV. METHODS: 
      Cross-sectional study among Ethiopian treatment-naive individuals with and 
      without HIV. Fat mass and fat-free mass adjusted for height (kg/m(2)) were used 
      as indicators of body composition. RESULTS: 288/100 individuals with/without HIV 
      were included between July 2010 and August 2012. Females with HIV had lower fat 
      mass index (FMI) and fat-free mass index (FFMI) than females without HIV, whereas 
      no difference was seen between males with and without HIV. Males and females with 
      HIV had lower grip strength than their counterparts without HIV. Serum 
      alpha-1-acid glycoprotein (s-AGP) was negatively correlated with FMI 
      (-0.71 kg/m(2), 95% CI: -1.2; -0.3) among individuals with HIV, and those with 
      HIV and serum C-reactive protein (s-CRP) >/= 10 mg/l had 0.78 kg/m(2) (95% CI -1.4; 
      -0.2) lower FMI than those with s-CRP < 10 mg/l. In contrast, s-AGP was 
      positively correlated with FMI (2.09 kg/m(2), 95% CI 0.6; 3.6) in individuals 
      without HIV. S-CRP and AGP were negatively associated with grip strength in 
      individuals with HIV, while no correlation was observed among those without HIV. 
      CONCLUSION: Inflammation was positively associated with FMI in individuals 
      without HIV while it was negatively associated with FMI in those with HIV, 
      indicating that inflammation may be one of the drivers of depleting energy 
      reserves among treatment-naive individuals with HIV. Inflammation was associated 
      with decreased muscle quantity and functional capacity among individuals with 
      HIV, but not in those without HIV.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Nature Limited.
FAU - Hegelund, Maria H
AU  - Hegelund MH
AUID- ORCID: 0000-0001-6287-1619
AD  - Department of Public Health, University of Copenhagen, Copenhagen, Denmark. 
      maria.hein.hegelund.01@regionh.dk.
AD  - Department of Pulmonary and Infectious Diseases, Nordsjaellands Hospital, 
      Hillerod, Denmark. maria.hein.hegelund.01@regionh.dk.
FAU - Faurholt-Jepsen, Daniel
AU  - Faurholt-Jepsen D
AD  - Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
FAU - Abdissa, Alemseged
AU  - Abdissa A
AD  - Department of Laboratory Sciences and Pathology, Jimma University, Jimma, 
      Ethiopia.
FAU - Yilma, Daniel
AU  - Yilma D
AD  - Department of Internal Medicine, Jimma University Specialized Hospital, Jimma, 
      Ethiopia.
FAU - Andersen, Ase B
AU  - Andersen AB
AD  - Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
FAU - Christensen, Dirk L
AU  - Christensen DL
AD  - Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
FAU - Wells, Jonathan C
AU  - Wells JC
AUID- ORCID: 0000-0003-0411-8025
AD  - Childhood Nutrition Research Centre, Population Policy and Practice Research and 
      Teaching Department, Great Ormond Street Institute of Child Health, University 
      College of London, London, UK.
FAU - Friis, Henrik
AU  - Friis H
AD  - Department of Nutrition, Exercise and Sports, University of Copenhagen, 
      Copenhagen, Denmark.
FAU - Girma, Tsinuel
AU  - Girma T
AD  - Department of Paediatrics and Child Health, Jimma University Specialized 
      Hospital, Jimma, Ethiopia.
FAU - Olsen, Mette F
AU  - Olsen MF
AD  - Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
AD  - Department of Nutrition, Exercise and Sports, University of Copenhagen, 
      Copenhagen, Denmark.
LA  - eng
PT  - Journal Article
DEP - 20220113
PL  - England
TA  - Eur J Clin Nutr
JT  - European journal of clinical nutrition
JID - 8804070
RN  - 0 (Biomarkers)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Biomarkers
MH  - *Body Composition/physiology
MH  - Body Mass Index
MH  - C-Reactive Protein
MH  - Cross-Sectional Studies
MH  - Ethiopia
MH  - Female
MH  - *HIV Infections/complications
MH  - Hand Strength
MH  - Humans
MH  - Inflammation
MH  - Male
EDAT- 2022/01/14 06:00
MHDA- 2022/07/14 06:00
CRDT- 2022/01/13 06:05
PHST- 2021/03/08 00:00 [received]
PHST- 2021/11/30 00:00 [accepted]
PHST- 2021/11/21 00:00 [revised]
PHST- 2022/01/14 06:00 [pubmed]
PHST- 2022/07/14 06:00 [medline]
PHST- 2022/01/13 06:05 [entrez]
AID - 10.1038/s41430-021-01056-4 [pii]
AID - 10.1038/s41430-021-01056-4 [doi]
PST - ppublish
SO  - Eur J Clin Nutr. 2022 Jul;76(7):973-978. doi: 10.1038/s41430-021-01056-4. Epub 
      2022 Jan 13.