PMID- 35023012
OWN - NLM
STAT- MEDLINE
DCOM- 20220719
LR  - 20220719
IS  - 1573-2630 (Electronic)
IS  - 0165-5701 (Linking)
VI  - 42
IP  - 7
DP  - 2022 Jul
TI  - Microperimetry, Humphrey field analyzer, and optical coherence tomography in 
      detecting glaucoma: a comparative performance study.
PG  - 2155-2165
LID - 10.1007/s10792-022-02215-7 [doi]
AB  - PURPOSE: To evaluate and compare the diagnostic performance of microperimetry 
      (MP), visual field (VF) 10-2 and 24-2 tests, and spectral-domain optical 
      coherence tomography (SD-OCT) in primary open-angle glaucoma (POAG). METHODS: The 
      study consisted of 35 POAG and 42 control eyes were enrolled in this prospective 
      study. Eligible participants were >/= 50 years old. VF assessments were carried out 
      using the Humphrey field analyzer (HFA) and Macular Integrity Assessment. Optic 
      nerve head (ONH), retinal nerve fiber layer thickness (RNFLT), and ganglion cell 
      inner-plexiform-layer thickness (GCIPLT) were measured by SD-OCT. Areas under the 
      receiver operating characteristic curves (AUC) and sensitivities at 95% 
      specificity were calculated for each parameter. RESULTS: HFA 24-2 had the largest 
      AUC value among the functional parameters to differentiate POAG from control eyes 
      [AUC: 0.950 (0.906-0.994), sensitivity at 95%:60]. HFA 24-2 showed a 
      significantly better performance than the 10-2 test (p = 0.036). Among the SD-OCT 
      structural parameters, minimum GCIPLT had the largest AUC value to differentiate 
      POAG from control eyes [AUC: 0.952 (0.905-0.999), sensitivity at 95%:80]. In 
      comparison of the functional and structural parameters, HFA 24-2 showed a 
      significantly better performance than the 10-2 test (p = 0.036). In macular 
      parameters, minimum GCPLT performed significantly better than HFA 10-2 
      (p = 0.015) in detecting POAG. There was no statistically significant difference 
      between the comparative diagnostic performance of the RNFL, ONH, HFA, and MP 
      (p > 0.05 for all comparisons). CONCLUSION: The structural and functional test 
      results revealed that GCIPLT measurements had the highest diagnostic performance 
      in detecting POAG. HFA 24-2 test performed better than 10-2 test in 
      distinguishing glaucoma from healthy eyes. MP showed a similar performance with 
      HFA 10-2 and may be considered a complementary diagnostic tool.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Nature B.V.
FAU - Akar, Serpil
AU  - Akar S
AD  - Department of Ophthalmology, Faculty of Medicine, Baskent University, Istanbul 
      Hospital, Kisikli Cad. Oymaci Sok.No: 7, Uskudar, Istanbul, Turkey. 
      akarserpil@yahoo.com.
FAU - Tekeli, Oya
AU  - Tekeli O
AD  - Department of Ophthalmology, Faculty of Medicine, Ankara University, Ankara, 
      Turkey.
FAU - Kayaarasi Ozturker, Zeynep
AU  - Kayaarasi Ozturker Z
AD  - Department of Ophthalmology, Faculty of Medicine, Baskent University, Istanbul 
      Hospital, Kisikli Cad. Oymaci Sok.No: 7, Uskudar, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20220113
PL  - Netherlands
TA  - Int Ophthalmol
JT  - International ophthalmology
JID - 7904294
SB  - IM
MH  - *Glaucoma/diagnosis
MH  - *Glaucoma, Open-Angle/diagnosis
MH  - Humans
MH  - Middle Aged
MH  - Prospective Studies
MH  - ROC Curve
MH  - Retinal Ganglion Cells
MH  - Tomography, Optical Coherence/methods
MH  - Visual Field Tests
OTO - NOTNLM
OT  - Diagnostic ability
OT  - Microperimetry
OT  - Optical coherence tomography
OT  - Primary open-angle glaucoma
OT  - Standard automated perimetry
EDAT- 2022/01/14 06:00
MHDA- 2022/07/20 06:00
CRDT- 2022/01/13 06:22
PHST- 2021/05/28 00:00 [received]
PHST- 2022/01/03 00:00 [accepted]
PHST- 2022/01/14 06:00 [pubmed]
PHST- 2022/07/20 06:00 [medline]
PHST- 2022/01/13 06:22 [entrez]
AID - 10.1007/s10792-022-02215-7 [pii]
AID - 10.1007/s10792-022-02215-7 [doi]
PST - ppublish
SO  - Int Ophthalmol. 2022 Jul;42(7):2155-2165. doi: 10.1007/s10792-022-02215-7. Epub 
      2022 Jan 13.