PMID- 35023370
OWN - NLM
STAT- MEDLINE
DCOM- 20220714
LR  - 20220718
IS  - 1758-1001 (Electronic)
IS  - 0004-5632 (Linking)
VI  - 59
IP  - 4
DP  - 2022 Jul
TI  - Reference interval for serum concentration of small dense low-density lipoprotein 
      cholesterol in the healthy Japanese population.
PG  - 242-252
LID - 10.1177/00045632211066334 [doi]
AB  - BACKGROUND: Small dense low-density lipoprotein a smaller and denser subfraction 
      among whole low density lipoprotein particles is known to be highly atherogenic. 
      The reference interval (RI) is not strictly defined for serum concentration of 
      sdLDL-cholesterol (sdLDL-C) in Japan. The purpose of this study is to set the 
      reference interval for sdLDL-C in healthy subjects. METHODS: The population of 
      this cross-sectional study was consisted of 40,862 individuals who had annual 
      health checkups, and healthy subjects were extracted based on exclusion criteria 
      such as medical history, social history, and blood sampling test results. Their 
      serum sdLDL-C values were statistically analyzed and the RIs were set in men, 
      premenopausal women, and postmenopausal women separately. RESULTS: The mean 
      values of serum sdLDL-C in healthy subjects were 23.9 mg/dL in men, 20.0 mg/dL in 
      premenopausal women and 23.7 mg/dL in postmenopausal women, and the RIs were 
      12.6-45.3 mg/dL in men, 11.4-35.1 mg/dL in premenopausal women and 
      14.6-38.6 mg/dL in postmenopausal women. Serum sdLDL-C values were significantly 
      higher in men than in women. Besides, sdLDL-C values were significantly higher in 
      postmenopausal women than in premenopausal women. In both genders, sdLDL-C values 
      tended to increase with age. CONCLUSION: These results suggest that the RIs for 
      sdLDL-C are recommended as follows: 13-45 mg/dL in men, 11-35 mg/dL in 
      premenopausal women, and 15-39 mg/dL in postmenopausal women, respectively. Aside 
      from these RIs, it is also necessary to define clinical cutoff values graded 
      according to individual risk levels for atherosclerotic cardiovascular diseases.
FAU - Nakamura, Marie
AU  - Nakamura M
AUID- ORCID: 0000-0002-0823-689X
AD  - Department of Insured Medical Care Management, Graduate School of Medical and 
      Dental Science, 92190Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
FAU - Yamamoto, Yasushi
AU  - Yamamoto Y
AD  - Kansai Occupational Health Association, 84047ACTY Health Evaluation Center, 
      Osaka, Japan.
FAU - Imaoka, Wataru
AU  - Imaoka W
AD  - Kansai Occupational Health Association, 84047ACTY Health Evaluation Center, 
      Osaka, Japan.
FAU - Kuroshima, Toshio
AU  - Kuroshima T
AD  - Kansai Occupational Health Association, 26799Senri LC Health Evaluation Center, 
      Osaka, Japan.
FAU - Toragai, Ryoko
AU  - Toragai R
AUID- ORCID: 0000-0002-8319-9929
AD  - Kansai Occupational Health Association, 26799Senri LC Health Evaluation Center, 
      Osaka, Japan.
FAU - Ito, Yasuki
AU  - Ito Y
AD  - Vaccine & Diagnostics R&D Department, Denka Co., Ltd, Niigata, Japan.
FAU - Yoshida, Hiroshi
AU  - Yoshida H
AD  - Department of Laboratory Medicine, Tokyo Jikei University Kashiwa Hospital, 
      Chiba, Japan.
FAU - Ai, Masumi
AU  - Ai M
AD  - Department of Insured Medical Care Management, Graduate School of Medical and 
      Dental Science, 92190Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20220221
PL  - England
TA  - Ann Clin Biochem
JT  - Annals of clinical biochemistry
JID - 0324055
RN  - 0 (Cholesterol, LDL)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
CIN - Ann Clin Biochem. 2022 May;59(3):157-158. PMID: 35188411
MH  - *Atherosclerosis/diagnosis
MH  - Cholesterol
MH  - *Cholesterol, LDL/blood
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Japan
MH  - Male
MH  - Reference Values
MH  - Risk Factors
OTO - NOTNLM
OT  - Small dense low density lipoprotein cholesterol
OT  - atherosclerosis
OT  - reference interval
EDAT- 2022/01/14 06:00
MHDA- 2022/07/15 06:00
CRDT- 2022/01/13 08:40
PHST- 2022/01/14 06:00 [pubmed]
PHST- 2022/07/15 06:00 [medline]
PHST- 2022/01/13 08:40 [entrez]
AID - 10.1177/00045632211066334 [doi]
PST - ppublish
SO  - Ann Clin Biochem. 2022 Jul;59(4):242-252. doi: 10.1177/00045632211066334. Epub 
      2022 Feb 21.