PMID- 35024356
OWN - NLM
STAT- MEDLINE
DCOM- 20220128
LR  - 20220128
IS  - 2235-2988 (Electronic)
IS  - 2235-2988 (Linking)
VI  - 11
DP  - 2021
TI  - Increased Total Serum Immunoglobulin E Is Likely to Cause Complications of 
      Mycoplasma pneumoniae Pneumonia in Children.
PG  - 783635
LID - 10.3389/fcimb.2021.783635 [doi]
LID - 783635
AB  - OBJECTIVE: To investigate the correlation between serum immunoglobulin E (IgE) 
      levels and the complications in children with Mycoplasma pneumoniae pneumonia 
      (MPP). METHODS: A retrospective study of MPP patients hospitalized from May 2019 
      to July 2021 was performed. We analyzed the clinical manifestations, 
      complications, laboratory findings, and treatments. RESULTS: A total of 275 
      patients who met the inclusion criteria were enrolled in the study. We divided 
      patients into two groups based on whether there were complications. Complications 
      occurred in 147 patients, of which pulmonary complications were more common than 
      extrapulmonary complications. The IgE level in the complication group was higher 
      than that in the non-complication group with p = 0.041. Patients with 
      complications of necrotizing pneumonitis, pneumothorax, skin rash, or 
      bronchiolitis obliterans had higher IgE levels. There was no statistically 
      significant difference in IgE levels between pulmonary complications and 
      extrapulmonary complications. The older the age, the greater the probability of 
      complications (p = 0.001). The group with complications was more likely to have 
      chest pain (p = 0.000), while the group without complications was more likely to 
      have wheezing (p = 0.017). The use of bronchoscopy and glucocorticoids was higher 
      in the complication group than in the non-complication group (p = 0.000). 
      CONCLUSIONS: MPP patients with higher IgE levels had more severe clinical 
      symptoms and complications. We speculated that IgE might be a biomarker for 
      complications after MP infection.
CI  - Copyright (c) 2021 Zhou, Li, Xu, Peng, Gong and Yang.
FAU - Zhou, Lili
AU  - Zhou L
AD  - Department of Respiratory Medicine, Women and Children's hospital, Gannan Medical 
      University, Ganzhou, China.
FAU - Li, Yuan
AU  - Li Y
AD  - Department of Respiratory Medicine, Women and Children's hospital, Gannan Medical 
      University, Ganzhou, China.
FAU - Xu, Zhufei
AU  - Xu Z
AD  - Department of Respiratory Medicine, The Children's Hospital, Zhejiang University, 
      Hangzhou, China.
FAU - Peng, Xuyun
AU  - Peng X
AD  - Department of Respiratory Medicine, Women and Children's hospital, Gannan Medical 
      University, Ganzhou, China.
FAU - Gong, Xiaoyan
AU  - Gong X
AD  - Department of Respiratory Medicine, Women and Children's hospital, Gannan Medical 
      University, Ganzhou, China.
FAU - Yang, Lin
AU  - Yang L
AD  - Department of Respiratory Medicine, Women and Children's hospital, Gannan Medical 
      University, Ganzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211124
PL  - Switzerland
TA  - Front Cell Infect Microbiol
JT  - Frontiers in cellular and infection microbiology
JID - 101585359
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Child
MH  - Humans
MH  - Immunoglobulin E
MH  - *Mycoplasma pneumoniae
MH  - *Pneumonia, Mycoplasma/complications
MH  - Retrospective Studies
PMC - PMC8744470
OTO - NOTNLM
OT  - Children
OT  - Immunoglobulin E
OT  - Mycoplasma pneumoniae
OT  - Severe Mycoplasma pneumoniae pneumonia
OT  - complications
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/01/14 06:00
MHDA- 2022/01/29 06:00
PMCR- 2021/01/01
CRDT- 2022/01/13 12:31
PHST- 2021/09/26 00:00 [received]
PHST- 2021/11/05 00:00 [accepted]
PHST- 2022/01/13 12:31 [entrez]
PHST- 2022/01/14 06:00 [pubmed]
PHST- 2022/01/29 06:00 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fcimb.2021.783635 [doi]
PST - epublish
SO  - Front Cell Infect Microbiol. 2021 Nov 24;11:783635. doi: 
      10.3389/fcimb.2021.783635. eCollection 2021.