PMID- 35024510
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220430
IS  - 2467-981X (Electronic)
IS  - 2467-981X (Linking)
VI  - 7
DP  - 2022
TI  - Fast acquisition of resting motor threshold with a stimulus-response curve - 
      Possibility or hazard for transcranial magnetic stimulation applications?
PG  - 7-15
LID - 10.1016/j.cnp.2021.10.005 [doi]
AB  - OBJECTIVE: Previous research has suggested that transcranial magnetic stimulation 
      (TMS) related cortical excitability measures could be estimated quickly using 
      stimulus-response curves with short interstimulus intervals (ISIs). Here we 
      evaluated the resting motor threshold (rMT) estimated with these curves. METHODS: 
      Stimulus-response curves were measured with three ISIs: 1.2-2 s, 2-3 s, and 
      3-4 s. Each curve was formed with 108 stimuli using stimulation intensities 
      ranging from 0.75 to 1.25 times the rMT(guess,) which was estimated based on 
      motor evoked potential (MEP) amplitudes of three scout responses. RESULTS: The 
      ISI did not affect the rMT estimated from the curves (F = 0.235, p = 0.683) or 
      single-trial MEP amplitudes at the group level (F = 0.90, p = 0.405), but a 
      significant subject by ISI interaction (F = 3.64; p < 0.001) was detected in MEP 
      amplitudes. No trend was observed which ISI was most excitable, as it varied 
      between subjects. CONCLUSIONS: At the group level, the stimulus-response curves 
      are unaffected by the short ISI. At the individual level, these curves are highly 
      affected by the ISI. SIGNIFICANCE: Estimating rMT using stimulus-response curves 
      with short ISIs impacts the rMT estimate and should be avoided in clinical and 
      research TMS applications.
CI  - (c) 2021 International Federation of Clinical Neurophysiology. Published by 
      Elsevier B.V.
FAU - Kallioniemi, Elisa
AU  - Kallioniemi E
AD  - Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX, United 
      States.
FAU - Awiszus, Friedemann
AU  - Awiszus F
AD  - Neuromuscular Research Group at the Department of Orthopaedics, Otto-von-Guericke 
      University, Magdeburg, Germany.
FAU - Pitkanen, Minna
AU  - Pitkanen M
AD  - Department of Applied Physics, University of Eastern Finland, Kuopio, Finland.
FAU - Julkunen, Petro
AU  - Julkunen P
AD  - Department of Applied Physics, University of Eastern Finland, Kuopio, Finland.
AD  - Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, 
      Finland.
LA  - eng
PT  - Journal Article
DEP - 20211217
PL  - Netherlands
TA  - Clin Neurophysiol Pract
JT  - Clinical neurophysiology practice
JID - 101684308
CIN - Clin Neurophysiol Pract. 2021 Dec 17;7:21-22. PMID: 35036660
PMC - PMC8733273
OTO - NOTNLM
OT  - APB, abductor pollicis brevis
OT  - EMG, electromyography
OT  - ISI, interstimulus interval
OT  - Interstimulus interval
OT  - MEP, motor evoked potential
OT  - MRI, magnetic resonance imaging
OT  - MSO, maximum stimulator output
OT  - Motor evoked potential
OT  - Motor threshold
OT  - SI, stimulation intensity
OT  - Stimulus-response curve
OT  - TMS, transcranial magnetic stimulation
OT  - rMT, resting motor threshold
OT  - rMTRR, resting motor threshold estimated with the Rossini-Rothwell method
OT  - rMTestimate, resting motor threshold estimated with stimulus-response curves
OT  - rMTguess, resting motor threshold estimated with prior information and three 
      scout pulses
OT  - rMTthreshold, resting motor threshold estimated with the threshold-hunting method
OT  - rMTtrue, true resting motor threshold in simulations
COIS- Petro Julkunen has a patent with Nexstim Plc (Helsinki, Finland), a manufacturer 
      of navigated TMS systems. Minna Pitkanen is employed by Bittium Biosignals Ltd 
      (Kuopio, Finland). The rest of the authors declare no competing interests.
EDAT- 2022/01/14 06:00
MHDA- 2022/01/14 06:01
PMCR- 2021/12/17
CRDT- 2022/01/13 12:34
PHST- 2021/03/18 00:00 [received]
PHST- 2021/09/15 00:00 [revised]
PHST- 2021/10/05 00:00 [accepted]
PHST- 2022/01/13 12:34 [entrez]
PHST- 2022/01/14 06:00 [pubmed]
PHST- 2022/01/14 06:01 [medline]
PHST- 2021/12/17 00:00 [pmc-release]
AID - S2467-981X(21)00052-4 [pii]
AID - 10.1016/j.cnp.2021.10.005 [doi]
PST - epublish
SO  - Clin Neurophysiol Pract. 2021 Dec 17;7:7-15. doi: 10.1016/j.cnp.2021.10.005. 
      eCollection 2022.