PMID- 35024748
OWN - NLM
STAT- MEDLINE
DCOM- 20220117
LR  - 20220308
IS  - 2066-8279 (Electronic)
IS  - 1220-0522 (Print)
IS  - 1220-0522 (Linking)
VI  - 62
IP  - 2
DP  - 2021 Apr-Jun
TI  - Peripheral-type primitive neuroectodermal tumor of the ovary with EWSR1-FLI1 
      fusion transcript: a case report and brief review of literature.
PG  - 581-586
LID - 10.47162/RJME.62.2.26 [doi]
AB  - Primitive neuroectodermal tumors (PNETs) of the ovary are extremely rare tumors 
      composed of undifferentiated small cells with round nuclei and scant cytoplasm. 
      They are rare in general and extremely rare in the female gynecological tract, 
      where they most commonly affect the ovary, followed by the uterine corpus. The 
      most common presenting symptoms are abdominal pain, bloating and the presence of 
      a pelvic mass. Diagnosis mainly relies on immunohistochemical and fluorescence in 
      situ hybridization (FISH). Due to the rarity of these tumors, there are no 
      standard therapeutic guidelines and treatment consists of surgery, various 
      chemotherapy regimens and/or radiotherapy. In this article, we report the case of 
      a 30-year-old female with peripheral-type PNET (pPNET) of the ovary featuring 
      Ewing sarcoma breakpoint region 1-Friend leukemia integration 1 (EWSR1-FLI1) 
      fusion transcript, confirmed by next-generation sequencing (NGS).
FAU - Grigoriu, Corina
AU  - Grigoriu C
AD  - Department of Pathology, Carol Davila University of Medicine and Pharmacy, 
      Bucharest, Romania; lisievici.carmen@yahoo.com, 
      tiberiuaugustin.georgescu@gmail.com.
FAU - Terzea, Dana Cristina
AU  - Terzea DC
FAU - Lisievici, Antonia Carmen
AU  - Lisievici AC
FAU - Georgescu, Tiberiu Augustin
AU  - Georgescu TA
FAU - Constantin, Andreea Elena
AU  - Constantin AE
FAU - Bacalbasa, Nicolae
AU  - Bacalbasa N
FAU - Ducu, Ionita
AU  - Ducu I
FAU - Bohiltea, Roxana Elena
AU  - Bohiltea RE
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - Romania
TA  - Rom J Morphol Embryol
JT  - Romanian journal of morphology and embryology = Revue roumaine de morphologie et 
      embryologie
JID - 9112454
RN  - 0 (EWSR1 protein, human)
RN  - 0 (EWSR1-FLI1 fusion protein, human)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (RNA-Binding Protein EWS)
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Neuroectodermal Tumors, Primitive/genetics
MH  - Oncogene Proteins, Fusion/genetics
MH  - Ovary
MH  - RNA-Binding Protein EWS/genetics
MH  - *Sarcoma, Ewing
PMC - PMC8848216
COIS- The authors declare that they have no conflict of interests.
EDAT- 2022/01/14 06:00
MHDA- 2022/01/18 06:00
PMCR- 2021/04/01
CRDT- 2022/01/13 12:38
PHST- 2022/01/13 12:38 [entrez]
PHST- 2022/01/14 06:00 [pubmed]
PHST- 2022/01/18 06:00 [medline]
PHST- 2021/04/01 00:00 [pmc-release]
AID - 620221581586 [pii]
AID - 10.47162/RJME.62.2.26 [doi]
PST - ppublish
SO  - Rom J Morphol Embryol. 2021 Apr-Jun;62(2):581-586. doi: 10.47162/RJME.62.2.26.