PMID- 35025058
OWN - NLM
STAT- MEDLINE
DCOM- 20220803
LR  - 20220822
IS  - 2192-4449 (Electronic)
IS  - 2192-4449 (Linking)
VI  - 11
IP  - 3
DP  - 2022 Aug
TI  - Involvement of neutrophil extracellular traps in the pathogenesis of 
      glomerulonephritis in a case of systemic lupus erythematosus and antineutrophil 
      cytoplasmic antibody-associated vasculitis overlap syndrome.
PG  - 339-346
LID - 10.1007/s13730-021-00682-y [doi]
AB  - Systemic lupus erythematosus (SLE) and antineutrophil cytoplasmic 
      antibody-associated vasculitis (AAV) are autoimmune diseases that often cause 
      rapidly progressive glomerulonephritis, with neutrophil extracellular traps 
      (NETs) involved in their pathogenesis. However, the involvement of NETs in the 
      renal damage caused by SLE/AAV overlap syndrome has not been clarified yet. In 
      this study, we detected renal deposition of NETs in a patient with SLE/AAV 
      overlap syndrome. In addition, a significantly increased level of NET-inducing 
      activity was observed in the patient's serum, which improved with treatment. On 
      the other hand, a markedly lower level of NET degradation was observed in the 
      patient's serum as compared to healthy subjects' sera, without any posttreatment 
      changes. These findings suggest that NETs may play a role in the pathogenesis of 
      renal injury associated with SLE/AAV overlap syndrome.
CI  - (c) 2022. The Author(s).
FAU - Senda, Arisa
AU  - Senda A
AD  - Department of Internal Medicine, Ako Municipal Hospital, 1090 Nakahiro, Ako, 
      Hyogo, 678-0232, Japan.
FAU - Sasai, Ryutaro
AU  - Sasai R
AD  - Department of Internal Medicine, Ako Municipal Hospital, 1090 Nakahiro, Ako, 
      Hyogo, 678-0232, Japan.
FAU - Kato, Kurumi
AU  - Kato K
AD  - Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido 
      University, Kita-12, Nishi-5, Kita-ku, Sapporo, Hokkaido, 060-0812, Japan.
FAU - Nishibata, Yuka
AU  - Nishibata Y
AD  - Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido 
      University, Kita-12, Nishi-5, Kita-ku, Sapporo, Hokkaido, 060-0812, Japan.
FAU - Masuda, Sakiko
AU  - Masuda S
AD  - Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido 
      University, Kita-12, Nishi-5, Kita-ku, Sapporo, Hokkaido, 060-0812, Japan.
FAU - Ishizu, Akihiro
AU  - Ishizu A
AD  - Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido 
      University, Kita-12, Nishi-5, Kita-ku, Sapporo, Hokkaido, 060-0812, Japan.
FAU - Takahara, Noriko
AU  - Takahara N
AD  - Department of Internal Medicine, Ako Municipal Hospital, 1090 Nakahiro, Ako, 
      Hyogo, 678-0232, Japan. norikot@amh.ako.hyogo.jp.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20220113
PL  - Japan
TA  - CEN Case Rep
JT  - CEN case reports
JID - 101636244
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
SB  - IM
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated 
      Vasculitis/complications/diagnosis
MH  - Antibodies, Antineutrophil Cytoplasmic
MH  - *Autoimmune Diseases/complications
MH  - *Extracellular Traps
MH  - *Glomerulonephritis/complications
MH  - Humans
MH  - *Lupus Erythematosus, Systemic/complications
MH  - Syndrome
PMC - PMC9343508
OTO - NOTNLM
OT  - ANCA-associated vasculitis
OT  - Neutrophil extracellular traps
OT  - Systemic lupus erythematosus
COIS- The authors have declared that no conflict of interest exists.
EDAT- 2022/01/14 06:00
MHDA- 2022/08/04 06:00
PMCR- 2022/01/13
CRDT- 2022/01/13 12:57
PHST- 2021/08/05 00:00 [received]
PHST- 2021/12/23 00:00 [accepted]
PHST- 2022/01/14 06:00 [pubmed]
PHST- 2022/08/04 06:00 [medline]
PHST- 2022/01/13 12:57 [entrez]
PHST- 2022/01/13 00:00 [pmc-release]
AID - 10.1007/s13730-021-00682-y [pii]
AID - 682 [pii]
AID - 10.1007/s13730-021-00682-y [doi]
PST - ppublish
SO  - CEN Case Rep. 2022 Aug;11(3):339-346. doi: 10.1007/s13730-021-00682-y. Epub 2022 
      Jan 13.