PMID- 35025099
OWN - NLM
STAT- MEDLINE
DCOM- 20220908
LR  - 20220914
IS  - 1933-7205 (Electronic)
IS  - 1933-7191 (Linking)
VI  - 29
IP  - 9
DP  - 2022 Sep
TI  - The Change of Oxidative Stress in Maternal Blood During Pregnancy.
PG  - 2580-2585
LID - 10.1007/s43032-022-00848-8 [doi]
AB  - Oxidative stress (OS) is a state in which the oxidative capacity exceeds the 
      antioxidant capacity in vivo. OS is associated with various perinatal diseases. 
      There have been few reports about OS during pregnancy, such as OS changes that 
      occur during gestation, normal maternal OS dynamics, and OS levels in umbilical 
      cord blood. We here examined the oxidative and antioxidant capacity in maternal 
      blood as well as in umbilical cord vein blood during normal pregnancy. Pregnant 
      women managed from early pregnancy to the postpartum period in our hospital, from 
      April 2018 to March 2019, were included. We obtained maternal blood at 12, 24, 
      and 36 weeks of gestation and obtained umbilical cord blood at delivery. The OS 
      (derivatives of reactive oxygen metabolites [d-ROMs]) and antioxidant capacity 
      (biological antioxidant potential [BAP]) of blood samples were measured. D-ROMs 
      and BAP were compared across gestational weeks. Moreover, d-ROMs and BAP were 
      compared between mothers with and without disease. We analyzed 100 pregnancies 
      (651 specimens). Eleven patients developed hypertensive disorder of pregnancy 
      (HDP)/preeclampsia (PE). The median maternal age was 35 years, and the median 
      gestational age at delivery was 39 weeks. Thirty-one women had undergone 
      fertility treatments. D-ROM values were significantly higher and BAP values were 
      significantly lower in mid- and late pregnancy than in early pregnancy. D-ROM and 
      BAP showed no significant differences between HDP/PE and non-hypertensive groups. 
      During pregnancy, maternal OS increases, and antioxidant capacity decreases with 
      advancing gestational age.
CI  - (c) 2022. Society for Reproductive Investigation.
FAU - Fukase, Mika
AU  - Fukase M
AUID- ORCID: 0000-0002-3530-0033
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine, Yamagata 
      University, Iida-nishi, 2-2-2, Yamagata, 990-9585, Japan. m.fukase3@gmail.com.
FAU - Watanabe, Norikazu
AU  - Watanabe N
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine, Yamagata 
      University, Iida-nishi, 2-2-2, Yamagata, 990-9585, Japan.
FAU - Yamanouchi, Keiko
AU  - Yamanouchi K
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine, Yamagata 
      University, Iida-nishi, 2-2-2, Yamagata, 990-9585, Japan.
FAU - Tsutsumi, Seiji
AU  - Tsutsumi S
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine, Yamagata 
      University, Iida-nishi, 2-2-2, Yamagata, 990-9585, Japan.
FAU - Nagase, Satoru
AU  - Nagase S
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine, Yamagata 
      University, Iida-nishi, 2-2-2, Yamagata, 990-9585, Japan.
LA  - eng
PT  - Journal Article
DEP - 20220113
PL  - United States
TA  - Reprod Sci
JT  - Reproductive sciences (Thousand Oaks, Calif.)
JID - 101291249
RN  - 0 (Antioxidants)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
EIN - Reprod Sci. 2022 Feb 2;:. PMID: 35112300
MH  - Adult
MH  - *Antioxidants/metabolism
MH  - Female
MH  - Fetal Blood/metabolism
MH  - Humans
MH  - Oxidative Stress
MH  - *Pre-Eclampsia/metabolism
MH  - Pregnancy
MH  - Reactive Oxygen Species/metabolism
OTO - NOTNLM
OT  - Biological antioxidant potential
OT  - Oxidative stress
OT  - Reactive oxygen metabolite derivatives
OT  - Reactive oxygen species
EDAT- 2022/01/14 06:00
MHDA- 2022/09/09 06:00
CRDT- 2022/01/13 12:59
PHST- 2021/10/01 00:00 [received]
PHST- 2022/01/06 00:00 [accepted]
PHST- 2022/01/14 06:00 [pubmed]
PHST- 2022/09/09 06:00 [medline]
PHST- 2022/01/13 12:59 [entrez]
AID - 10.1007/s43032-022-00848-8 [pii]
AID - 10.1007/s43032-022-00848-8 [doi]
PST - ppublish
SO  - Reprod Sci. 2022 Sep;29(9):2580-2585. doi: 10.1007/s43032-022-00848-8. Epub 2022 
      Jan 13.