PMID- 35025313
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220113
IS  - 2576-6422 (Electronic)
IS  - 2576-6422 (Linking)
VI  - 3
IP  - 4
DP  - 2020 Apr 20
TI  - Antibacterial Polylactic-co-glycolic Acid Braided Threads Using Plasma and 
      Coating Modifications for Acupoint Catgut Embedding Therapy Applications.
PG  - 1902-1912
LID - 10.1021/acsabm.9b01071 [doi]
AB  - Polylactic-co-glycolic acid (PLGA) thread is frequently used for acupoint catgut 
      embedding therapy (ACET), but the poor hydrophilicity and biocompatibility 
      largely limited its wider applications. The aim of this study is to functionalize 
      the PLGA braided thread and improve its cell adhesion property. The PLGA strands 
      are first processed into threads on a circular braiding machine, and then, 
      antibacterial treatment was introduced with and without oxygen plasma treatments. 
      Afterward, functional characterizations such as antibacterial activity 
      (Staphylococcus aureus and Escherichia coli), cytotoxicity, cell attachment and 
      cell morphology, histological observation, and biodegradation experiments of 
      threads were measured. Moreover, tensile properties and flexibility of the 
      threads were determined to evaluate their mechanical properties. The modified 
      threads showed rougher surfaces than those of the unmodified ones from SEM 
      observations, and the weights and fiber diameters of the threads increased 
      correspondingly, together with the improved surface hydrophilicity. All coated 
      sutures showed durable antimicrobial function and slow drug releasing features 
      for more than 5 days and good cell viability (more than 75%), according to the 
      standard of ISO 10993-5:2009. Besides, cell attachment, tissue growth, and 
      collagen regeneration of plasma-treated samples were greatly improved compared to 
      those of without the plasma treatment. The threads presented slow degradation 
      behavior after the antibacterial treatment. The threads with only plasma-treated 
      revealed a promising prospect for clinical applications.
FAU - Fu, Shaoju
AU  - Fu S
AD  - Key Laboratory of Textile Science and Technology, Ministry of Education, College 
      of Textiles, Donghua University, Shanghai 201620, China.
FAU - Yang, Dongchao
AU  - Yang D
AD  - Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong 
      University, Shanghai 200011, China.
FAU - Zhang, Peihua
AU  - Zhang P
AUID- ORCID: 0000-0002-1538-4890
AD  - Key Laboratory of Textile Science and Technology, Ministry of Education, College 
      of Textiles, Donghua University, Shanghai 201620, China.
FAU - Sun, Gang
AU  - Sun G
AUID- ORCID: 0000-0002-6608-9971
AD  - Department of Biological and Agricultural Engineering, University of California, 
      Davis, Davis, California 95616, United States.
LA  - eng
PT  - Journal Article
DEP - 20200402
PL  - United States
TA  - ACS Appl Bio Mater
JT  - ACS applied bio materials
JID - 101729147
SB  - IM
OTO - NOTNLM
OT  - acupoint catgut embedding therapy (ACET)
OT  - antibacterial
OT  - plasma
OT  - polylactic-co-glycolic acid (PLGA)
OT  - surface modification
EDAT- 2020/04/20 00:00
MHDA- 2020/04/20 00:01
CRDT- 2022/01/13 17:13
PHST- 2022/01/13 17:13 [entrez]
PHST- 2020/04/20 00:00 [pubmed]
PHST- 2020/04/20 00:01 [medline]
AID - 10.1021/acsabm.9b01071 [doi]
PST - ppublish
SO  - ACS Appl Bio Mater. 2020 Apr 20;3(4):1902-1912. doi: 10.1021/acsabm.9b01071. Epub 
      2020 Apr 2.