PMID- 35026510
OWN - NLM
STAT- MEDLINE
DCOM- 20220125
LR  - 20220125
IS  - 1618-095X (Electronic)
IS  - 0944-7113 (Linking)
VI  - 96
DP  - 2022 Feb
TI  - Herbal nanomedicines: Recent advancements, challenges, opportunities and 
      regulatory overview.
PG  - 153890
LID - S0944-7113(21)00430-X [pii]
LID - 10.1016/j.phymed.2021.153890 [doi]
AB  - BACKGROUND: Herbal Nano Medicines (HNMs) are nano-sized medicine containing 
      herbal drugs as extracts, enriched fractions or biomarker constituents. HNMs have 
      certain advantages because of their increased bioavailability and reduced 
      toxicities. There are very few literature reports that address the common 
      challenges of herbal nanoformulations, such as selecting the type/class of 
      nanoformulation for an extract or a phytochemical, selection and optimisation of 
      preparation method and physicochemical parameters. Although researchers have 
      shown more interest in this field in the last decade, there is still an urgent 
      need for systematic analysis of HNMs. PURPOSE: This review aims to provide the 
      recent advancement in various herbal nanomedicines like polymeric herbal 
      nanoparticles, solid lipid nanoparticles, phytosomes, nano-micelles, self-nano 
      emulsifying drug delivery system, nanofibers, liposomes, dendrimers, ethosomes, 
      nanoemulsion, nanosuspension, and carbon nanotube; their evaluation parameters, 
      challenges, and opportunities. Additionally, regulatory aspects and future 
      perspectives of herbal nanomedicines are also being covered to some extent. 
      METHODS: The scientific data provided in this review article are retrieved by a 
      thorough analysis of numerous research and review articles, textbooks, and 
      patents searched using the electronic search tools like Sci-Finder, 
      ScienceDirect, PubMed, Elsevier, Google Scholar, ACS, Medline Plus and Web of 
      Science. RESULTS: In this review, the authors suggested the suitability of 
      nanoformulation for a particular type of extracts or enriched fraction of 
      phytoconstituents based on their solubility and permeability profile (similar to 
      the BCS class of drugs). This review focuses on different strategies for 
      optimising preparation methods for various HNMs to ensure reproducibility in 
      context with all the physicochemical parameters like particle size, surface area, 
      zeta potential, polydispersity index, entrapment efficiency, drug loading, and 
      drug release, along with the consistent therapeutic index. CONCLUSION: A 
      combination of herbal medicine with nanotechnology can be an essential tool for 
      the advancement of herbal medicine research with enhanced bioavailability and 
      fewer toxicities. Despite the challenges related to traditional medicine's safe 
      and effective use, there is huge scope for nanotechnology-based herbal medicines. 
      Overall, it is well stabilized that herbal nanomedicines are safer, have higher 
      bioavailability, and have enhanced therapeutic value than conventional herbal and 
      synthetic drugs.
CI  - Copyright (c) 2021 Elsevier GmbH. All rights reserved.
FAU - Teja, Parusu Kavya
AU  - Teja PK
AD  - National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A), 
      An Institute of National Importance, Government of India, Department of 
      Pharmaceuticals, Ministry of Chemicals and Fertilizers, Opp. Air Force Station, 
      Palaj, Gandhinagar, 382355, Gujarat, India.
FAU - Mithiya, Jinal
AU  - Mithiya J
AD  - National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A), 
      An Institute of National Importance, Government of India, Department of 
      Pharmaceuticals, Ministry of Chemicals and Fertilizers, Opp. Air Force Station, 
      Palaj, Gandhinagar, 382355, Gujarat, India.
FAU - Kate, Abhijeet S
AU  - Kate AS
AD  - National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A), 
      An Institute of National Importance, Government of India, Department of 
      Pharmaceuticals, Ministry of Chemicals and Fertilizers, Opp. Air Force Station, 
      Palaj, Gandhinagar, 382355, Gujarat, India.
FAU - Bairwa, Khemraj
AU  - Bairwa K
AD  - National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A), 
      An Institute of National Importance, Government of India, Department of 
      Pharmaceuticals, Ministry of Chemicals and Fertilizers, Opp. Air Force Station, 
      Palaj, Gandhinagar, 382355, Gujarat, India.. Electronic address: 
      khemraj92@gmail.com.
FAU - Chauthe, Siddheshwar K
AU  - Chauthe SK
AD  - National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A), 
      An Institute of National Importance, Government of India, Department of 
      Pharmaceuticals, Ministry of Chemicals and Fertilizers, Opp. Air Force Station, 
      Palaj, Gandhinagar, 382355, Gujarat, India.. Electronic address: 
      Siddheshwar.chauthe@niperahm.ac.in.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20211217
PL  - Germany
TA  - Phytomedicine
JT  - Phytomedicine : international journal of phytotherapy and phytopharmacology
JID - 9438794
RN  - 0 (Lipid Nanoparticles)
RN  - 0 (Liposomes)
SB  - IM
MH  - Drug Delivery Systems
MH  - Liposomes
MH  - *Nanomedicine
MH  - *Nanoparticles
MH  - Reproducibility of Results
OTO - NOTNLM
OT  - Herbal drugs
OT  - Herbal nano medicine (HNMs)
OT  - Marker constituents
OT  - and Ayurveda
EDAT- 2022/01/14 06:00
MHDA- 2022/01/27 06:00
CRDT- 2022/01/13 20:22
PHST- 2021/04/18 00:00 [received]
PHST- 2021/11/14 00:00 [revised]
PHST- 2021/12/11 00:00 [accepted]
PHST- 2022/01/14 06:00 [pubmed]
PHST- 2022/01/27 06:00 [medline]
PHST- 2022/01/13 20:22 [entrez]
AID - S0944-7113(21)00430-X [pii]
AID - 10.1016/j.phymed.2021.153890 [doi]
PST - ppublish
SO  - Phytomedicine. 2022 Feb;96:153890. doi: 10.1016/j.phymed.2021.153890. Epub 2021 
      Dec 17.